{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:55:50Z","timestamp":1772556950267,"version":"3.50.1"},"reference-count":71,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Health Industry Scientific Research Project of Gansu Province","award":["GSWSKY2018-35"],"award-info":[{"award-number":["GSWSKY2018-35"]}]},{"name":"\"Cuiying Science and Technology Innovation\" program of Lanzhou University Second Hospital","award":["CY2018-MS01"],"award-info":[{"award-number":["CY2018-MS01"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81960165"],"award-info":[{"award-number":["81960165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The medical community acknowledges the presence of thyroid disorders and\n                    nonalcoholic fatty liver disease (NAFLD). Nevertheless, the interconnection\n                    between these two circumstances is complex. Thyroid hormones (THs), including\n                    triiodothyronine (T3) and thyroxine (T4), and thyroid-stimulating hormone (TSH),\n                    are essential for maintaining metabolic balance and controlling the metabolism\n                    of lipids and carbohydrates. The therapeutic potential of THs, especially those\n                    that target the TR\u03b2 receptor isoform, is generating increasing interest. The\n                    review explores the pathophysiology of these disorders, specifically examining\n                    the impact of THs on the metabolism of lipids in the liver. The purpose of this\n                    review is to offer a thorough analysis of the correlation between thyroid\n                    disorders and NAFLD, as well as suggest potential therapeutic approaches for the\n                    future.<\/jats:p>","DOI":"10.1055\/a-2276-7973","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:06:46Z","timestamp":1708992406000},"page":"697-705","source":"Crossref","is-referenced-by-count":2,"title":["Cross-Talk Between Thyroid Disorders and Nonalcoholic Fatty Liver\n                    Disease: From Pathophysiology to Therapeutics"],"prefix":"10.1055","volume":"56","author":[{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Lanzhou University Second\n                    Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyuan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Lanzhou University Second Hospital,\n                    Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Lanzhou University Second Hospital,\n                    Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery ICU, Lanzhou University Second Hospital,\n                    Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/ijms17030367","article-title":"Bidirectional relationships and 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(Oxf)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12902-015-0030-5","article-title":"Subclinical and clinical hypothyroidism and non-alcoholic fatty liver disease: a\n                    cross-sectional study of a random population sample aged 18 to 65 years","volume":"15","author":"U Ludwig","year":"2015","journal-title":"BMC Endocr Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1007\/s10620-019-05687-3","article-title":"Low free triiodothyronine is associated with advanced fibrosis in patients at\n                    high risk for nonalcoholic steatohepatitis","volume":"64","author":"P Manka","year":"2019","journal-title":"Dig Dis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1089\/thy.2018.0257","article-title":"Association between primary hypothyroidism and nonalcoholic fatty liver disease:\n                    a systematic review and meta-analysis","volume":"28","author":"A Mantovani","year":"2018","journal-title":"Thyroid"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jhep.2012.02.027","article-title":"Non-alcoholic fatty liver disease across the spectrum of hypothyroidism","volume":"57","author":"G E Chung","year":"2012","journal-title":"J Hepatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.3390\/jcm10132907","article-title":"TSH levels as an independent risk factor for NAFLD and liver fibrosis in the\n                    general population","volume":"10","author":"A Mart\u00ednez-Escud\u00e9","year":"2021","journal-title":"J Clin Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/jim-2015-000019","article-title":"Plasma thyroid hormone concentration is associated with hepatic triglyceride\n                    content in patients with type 2 diabetes","volume":"64","author":"F Bril","year":"2016","journal-title":"J Investig 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Endocrinol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"101266","DOI":"10.1016\/j.molmet.2021.101266","article-title":"Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during\n                    NAFLD progression","volume":"53","author":"E Bruinstroop","year":"2021","journal-title":"Mol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1210\/en.2014-1302","article-title":"Repair-related activation of hedgehog signaling in stromal cells promotes\n                    intrahepatic hypothyroidism","volume":"155","author":"B N Bohinc","year":"2014","journal-title":"Endocrinology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.dsx.2018.08.021","article-title":"The influence of subclinical hypothyroidism on serum lipid profile, PCSK9 levels\n                    and CD36 expression on monocytes","volume":"13","author":"M Fazaeli","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1194\/jlr.M051664","article-title":"Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans","volume":"55","author":"Y Bonde","year":"2014","journal-title":"J Lipid Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/0006-291X(90)91568-D","article-title":"Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL\n                    receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and\n                    apolipoprotein A-I mRNA levels in hypophysectomized rats","volume":"172","author":"G C Ness","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/hep.25861","article-title":"Stimulation of murine biliary cholesterol secretion by thyroid hormone is\n                    dependent on a functional ABCG5\/G8 complex","volume":"56","author":"Y Bonde","year":"2012","journal-title":"Hepatology"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1515\/hmbci-2018-0047","article-title":"Hypothyroidism and nonalcoholic fatty liver disease \u2013 a chance association?","author":"S Lugari","year":"2018","journal-title":"Horm Mol Biol Clin Investig"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/hep.23800","article-title":"A novel role for thyroid-stimulating hormone: up-regulation of hepatic\n                    3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic\n                    adenosine monophosphate\/protein kinase A\/cyclic adenosine\n                    monophosphate-responsive element binding protein pathway","volume":"52","author":"L Tian","year":"2010","journal-title":"Hepatology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.jhep.2014.12.006","article-title":"Thyroid-stimulating hormone regulates 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Araki","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1210\/en.2011-1793","article-title":"Thyroid hormone receptor-\u03b1 gene knockout mice are protected from diet-induced\n                    hepatic insulin resistance","volume":"153","author":"F R Jornayvaz","year":"2012","journal-title":"Endocrinology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"E89","DOI":"10.1152\/ajpendo.00573.2012","article-title":"Thyroid hormone receptor-\u03b2 agonists prevent hepatic steatosis in fat-fed rats\n                    but impair insulin sensitivity via discrete pathways","volume":"305","author":"D F Vatner","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1016\/j.ajpath.2017.07.005","article-title":"Thyroid hormone receptor-\u03b2 agonist GC-1 inhibits met-\u03b2-catenin-driven\n                    hepatocellular 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receptor agonist","volume":"49","author":"E E Cable","year":"2009","journal-title":"Hepatology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1089\/thy.2019.0007","article-title":"A liver-specific thyromimetic, VK2809, decreases hepatosteatosis in glycogen\n                    storage disease type Ia","volume":"29","author":"J Zhou","year":"2019","journal-title":"Thyroid"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1016\/S0618-8278(19)30266-X","article-title":"LBP-20-VK2809, a novel liver-directed thyroid receptor beta agonist,\n                    significantly reduces liver fat with both low and high doses in patients with\n                    non-alcoholic fatty liver disease: a phase 2 randomized, placebo-controlled\n                    trial","volume":"70","author":"R Loomba","year":"2019","journal-title":"J 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