{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:33:00Z","timestamp":1788316380870,"version":"build-2803163510"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Diclofenac is the non-steroidal anti-inflammatory drug (NSAID)\n                    mostly prescribed worldwide, but it is highly associated with hypertension and\n                    acute kidney injury. Despite that, little information is available about the\n                    renal effects of diclofenac in hypertensive individuals, which led us to carry\n                    out this comparative study between the renal effects of this NSAID in\n                    normotensive (NTR) and spontaneously hypertensive rats (SHR).<\/jats:p><jats:p>\n          Methods Male Wistar NTR and SHR were orally treated with vehicle (V:\n                    10\u2009mL\/kg) or diclofenac sodium (D: 100\u2009mg\/kg) once a day for 3 days. Urine\n                    volume, electrolytes excretion (Na+, K+, Cl-,\n                    and Ca2+), urea, creatinine, pH, and osmolarity were evaluated.\n                    Furthermore, blood samples and renal tissue were collected to perform\n                    biochemical and histological analysis.<\/jats:p><jats:p>\n          Results Diclofenac increased the renal corpuscle and bowman\u2019s space in the\n                    SHR, while no microscopic changes were observed in the renal tissue of NTR.\n                    Regarding the urinary parameters, diclofenac reduced urine volume, pH,\n                    osmolarity, and all electrolytes excretion, followed by decreased urea and\n                    creatinine levels in both lineages. Moreover, it also induced hyponatremia,\n                    hypokalemia, and hypocalcemia in SHR, while reduced\n                    glutathione-S-transferase activity, lipid hydroperoxides, and nitrite\n                    levels in renal tissue.<\/jats:p><jats:p>\n          Conclusions The data presented herein demonstrated that diclofenac induces\n                    renal damage and impaired renal function in both NTR and SHR, but those effects\n                    are exacerbated in SHR, as seen by the histological changes and electrolytes\n                    balance disturbance, therefore, reinforcing that diclofenac may increase the\n                    risks of cardiovascular events in hypertensive patients.<\/jats:p>","DOI":"10.1055\/a-2277-8458","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T23:36:47Z","timestamp":1710891407000},"page":"171-179","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of Diclofenac-induced Renal Damage in Normotensive\n                    and Hypertensive Rats: A Comparative Analysis"],"prefix":"10.1055","volume":"74","author":[{"given":"Thaise","family":"Boeing","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Nucleus of\n                    Chemical-Pharmaceutical Investigations, University of Vale do Itaja\u00ed, Itaja\u00ed,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana Bittencourt F.","family":"Lima","sequence":"additional","affiliation":[{"name":"Pharmacy Course, School of Health Sciences, University of Vale do\n                    Itaja\u00ed, Itaja\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eduarda","family":"Busana","sequence":"additional","affiliation":[{"name":"Pharmacy Course, School of Health Sciences, University of Vale do\n                    Itaja\u00ed, Itaja\u00ed, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Nath\u00e1lia Bolda","family":"Mariano","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Nucleus of\n                    Chemical-Pharmaceutical Investigations, University of Vale do Itaja\u00ed, Itaja\u00ed,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Nucleus of\n                    Chemical-Pharmaceutical Investigations, University of Vale do Itaja\u00ed, Itaja\u00ed,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita de C\u00e1ssia Vilhena da","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Nucleus of\n                    Chemical-Pharmaceutical Investigations, University of Vale do Itaja\u00ed, Itaja\u00ed,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmaceutical Sciences, Nucleus of\n                    Chemical-Pharmaceutical Investigations, University of Vale do Itaja\u00ed, Itaja\u00ed,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s40265-015-0392-z","article-title":"Advances in NSAID development: Evolution of diclofenac products using\n                    pharmaceutical technology","volume":"75","author":"R Altman","year":"2015","journal-title":"Drugs"},{"key":"ref2","first-page":"1","volume-title":"Diclofenac. 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