{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:46:25Z","timestamp":1772102785709,"version":"3.50.1"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The presentation of the results of the prospective randomized international multicenter GCIG INTERLACE trial at the 2023 congress of the European Society of Medical Oncology (ESMO) is likely to change the therapy for locally advanced cervical cancer. In the GCIG INTERLACE trial, six cycles of neoadjuvant chemotherapy administered weekly and consisting of carboplatin AUC2 and paclitaxel 80\u2009mg\/m2 followed by definitive radiochemotherapy with pelvic radiotherapy (40\u200a\u2013\u200a50.4\u00a0Gray) and cisplatin (40\u2009mg\/m2 once a week for 5 weeks) and brachytherapy (total dose EQD2 at least 78\u2009Gy at point A) (experimental arm) were compared with definitive radiochemotherapy alone (standard arm) in patients with locally advanced cervical cancer (F\u00e9d\u00e9ration Internationale de Gyn\u00e9cologie et d\u02bcObst\u00e9trique [FIGO] 2008 stage IB1\/node positive, IB2, II, IIIB and IVA) and was found to be significantly superior with significantly longer recurrence-free survival (hazard ratio [HR] 0.65;\n          95% confidence interval [CI] 0.64\u200a\u2013\u200a0.91; p\u2009=\u20090.013) and significantly longer overall survival rates (HR 0.61; 95% CI: 0.40\u200a\u2013\u200a0.91; p\u2009=\u20090.04) after 5 years\u02bc follow-up. After considering the results of the GCIG INTERLACE trial published at the congress, the Uterus Commission of the AGO is of the opinion that neoadjuvant chemotherapy with carboplatin AUC2 and paclitaxel 80\u2009mg\/m2 d1, q7, x6 may be offered to patients with locally advanced cervical cancer (FIGO stage IB1\/node positive, IB2, II, IIIB and IVA) in addition to the current standard therapy after the patient has been informed about the risks, with the decision taken on a case-by-case basis. However, before this approach can be discussed at guideline level or defined as the new therapy standard, it will be necessary to wait until the data from the full publication are available.<\/jats:p>","DOI":"10.1055\/a-2279-3163","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T19:59:42Z","timestamp":1713211182000},"page":"523-528","source":"Crossref","is-referenced-by-count":3,"title":["Statement of the Uterus Commission of the Gynecological Oncology Working Group (AGO) on Neoadjuvant Chemotherapy Prior to Definitive Radiochemotherapy in Patients with Locally Advanced Cervical Cancer"],"prefix":"10.1055","volume":"84","author":[{"given":"Clemens","family":"Tempfer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik, Comprehensive Cancer Center der Ruhr Universit\u00e4t Bochum (RUCCC), Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Fehm","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik der Universit\u00e4t D\u00fcsseldorf, CIO ABCD, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Vordermark","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Strahlentherapie der Martin-Luther-Universit\u00e4t Halle-Wittenberg, Halle-Wittenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Marnitz-Schulze","sequence":"additional","affiliation":[{"name":"RadioOnkologie im Vosspalais, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias W.","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Frauenklinik, Comprehensive Cancer Center ER-EMN, Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Denschlag","sequence":"additional","affiliation":[{"name":"Frauenklinik, Hochtaunus Kliniken Bad Homburg, Bad Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Brucker","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsfrauenklinik T\u00fcbingen, Department f\u00fcr Frauengesundheit, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik und Poliklinik f\u00fcr Gyn\u00e4kologie der Martin-Luther-Universit\u00e4t Halle-Wittenberg, Halle-Wittenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Eichbaum","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Frauenheilkunde und Geburtshilfe, Helios HSK Wiesbaden, Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyhan","family":"Ataseven","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Universit\u00e4t Bielefeld UK OWL, Klinikum Lippe, Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hillemanns","sequence":"additional","affiliation":[{"name":"Frauenklinik, Comprehensive Cancer Center Niedersachsen, Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"f\u00fcr die Kommission Uterus der AGO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"issue":"S 2","key":"ref1","doi-asserted-by":"crossref","first-page":"S1276","DOI":"10.1016\/j.annonc.2023.10.028","article-title":"A randomised phase III trial of induction 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