{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:30:35Z","timestamp":1790202635565,"version":"4.1.0"},"reference-count":122,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The main purpose of this article is to explore the relationship between autophagy\n                    and the pathological mechanism of PCOS, and to find potential therapeutic\n                    methods that can alleviate the pathological mechanism of PCOS by targeting\n                    autophagy. Relevant literatures were searched in the following databases,\n                    including: PubMed, MEDLINE, Web of Science, Scopus. The search terms were\n                    \u201cautophagy\u201d, \u201cPCOS\u201d, \u201cpolycystic ovary syndrome\u201d, \u201covulation\u201d,\n                    \u201chyperandrogenemia\u201d, \u201cinsulin resistance\u201d, \u201cinflammatory state\u201d, \u201ccircadian\n                    rhythm\u201d and \u201ctreatment\u201d, which were combined according to the retrieval methods\n                    of different databases. Through analysis, we uncovered that abnormal levels of\n                    autophagy were closely related to abnormal ovulation, insulin resistance,\n                    hyperandrogenemia, and low-grade inflammation in patients with PCOS. Lifestyle\n                    intervention, melatonin, vitamin D, and probiotics, etc. were able to improve\n                    the pathological mechanism of PCOS via targeting autophagy. In conclusion,\n                    autophagy disorder is a key pathological mechanism in PCOS and is also a\n                    potential target for drug development and design.<\/jats:p>","DOI":"10.1055\/a-2280-7130","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T23:39:02Z","timestamp":1712101142000},"page":"547-558","source":"Crossref","is-referenced-by-count":8,"title":["A Retrospective Review on Dysregulated Autophagy in Polycystic Ovary\n                    Syndrome: From Pathogenesis to Therapeutic Strategies"],"prefix":"10.1055","volume":"56","author":[{"given":"Yan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital of Heilongjiang\n                    University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine (TCM) Gynecology, Hangzhou\n                    TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyue","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital of Heilongjiang\n                    University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital of Heilongjiang\n                    University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuepeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science, Zhejiang Chinese Medical University,\n                    Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital of Heilongjiang\n                    University of Chinese Medicine, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"R Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related\n                    to polycystic ovary syndrome","volume":"81","author":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop\n                          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