{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:30:36Z","timestamp":1730871036839,"version":"3.28.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die neurogene Dysfunktion des unteren Harntrakts bei Multipler Sklerose wird h\u00e4ufig\n      untersch\u00e4tzt, unterdiagnostiziert und unzureichend behandelt. Sie tritt in Abh\u00e4ngigkeit vom\n      Krankheitsverlauf und der Lokalisation der nervalen Sch\u00e4digung in unterschiedlicher H\u00e4ufigkeit\n      und in Form verschiedenster St\u00f6rungen von Harnspeicherung und Harnentleerung auf. Symptome wie\n      Harninkontinenz, rezidivierende Harnwegsinfektionen, Drangsymptomatik, Pollakisurie,\n      abgeschw\u00e4chter Harnstrahl, Startverz\u00f6gerung sowie Restharnbildung sind m\u00f6glich. Jedoch erlaubt\n      die Symptomatik keinen R\u00fcckschluss auf die zugrunde liegende Art der neurogenen Dysfunktion\n      des unteren Harntrakts. <\/jats:p><jats:p>Zwar liegen heute zahlreiche Daten, Publikationen und Leitlinien zu diesem Thema vor;\n      einheitliche, in prospektiven Studien \u00fcberpr\u00fcfte Screeningparameter und Algorithmen stehen f\u00fcr\n      die Multiple Sklerose jedoch aus. <\/jats:p><jats:p>Diese \u00dcbersicht stellt die aktuellen diagnostischen und therapeutischen M\u00f6glichkeiten der\n      neurogenen Dysfunktion des unteren Harntrakts bei Multipler Sklerose dar. Problematisch ist\n      hierbei die initial deutlich verz\u00f6gerte Diagnosestellung, welche nicht zuletzt auf eine\n      mangelnde Kommunikation zwischen Neurolog\/innen und Urolog\/innen zur\u00fcckzuf\u00fchren ist. Erste\n      Hinweise auf das Vorhandensein einer neurogenen Dysfunktion des unteren Harntrakts ergeben\n      sich aus aktivem Fragen nach subjektivem Vorhandensein von Symptomen wie Harninkontinenz oder\n      Auftreten von Harnwegsinfekten. Allerdings schlie\u00dft eine subjektive Symptomlosigkeit eine\n      neurogene Dysfunktion des unteren Harntrakts nicht aus. <\/jats:p><jats:p>Unabh\u00e4ngig vom Krankheitsstadium soll fr\u00fchzeitig und individualisiert eine\n      neuro-urologische Diagnostik und Therapie erfolgen. Bei der neuro-urologischen\n      Therapieentscheidung sind alle Sch\u00e4digungsaspekte und der Umfang der Funktionsdefizite anderer\n      Organsysteme im Rahmen der Grunderkrankung der Multiplen Sklerose zu ber\u00fccksichtigen. <\/jats:p><jats:p>Letztlich ist der enge und konsequente interdisziplin\u00e4re Austausch zwischen Neurologie,\n      Allgemeinmedizin und Urologie unerl\u00e4sslich. Dieses interdisziplin\u00e4re und interprofessionelle\n      Denken und Handeln ist Voraussetzung, um die zahlreichen konservativen und invasiven\n      therapeutischen Ma\u00dfnahmen optimal zur Anwendung bringen zu k\u00f6nnen. Eine lebenslange,\n      individuelle, risikoadaptierte urologische Betreuung zur Fr\u00fcherkennung und Pr\u00e4vention\n      neuro-urologischer Komplikationen soll Betroffenen mit Multipler Sklerose angeboten werden. <\/jats:p>","DOI":"10.1055\/a-2281-7924","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T23:35:05Z","timestamp":1713915305000},"page":"315-325","source":"Crossref","is-referenced-by-count":0,"title":["Neuro-urologische Diagnostik und Therapie nicht traumatischer\/degenerativ bedingter neurogener Dysfunktion des unteren Harntraktes am Beispiel der Multiplen Sklerose"],"prefix":"10.1055","volume":"55","author":[{"given":"Ines","family":"Kurze","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Paraplegiologie und Neuro-Urologie, Zentralklinik Bad Berka Gmbh, Bad Berka, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke K.","family":"Jaekel","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Urologie und Kinderurologie, Sektion Neuro-Urologie, Universit\u00e4tsklinikum Bonn, Bonn, Germany"},{"name":"Neuro-Urologie, Johanniter Neurologisches Rehabilitationszentrum Godeshoehe GmbH, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/j.1468-1331.2006.01342.x","article-title":"The epidemiology of multiple sclerosis in Europe","volume":"13","author":"M Pugliatti","year":"2006","journal-title":"Eur J Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.5489\/cuaj.4058","article-title":"Evaluation of lower urinary tract symptoms in multiple sclerosis patients: Review\n          of the literature and current guidelines","volume":"11","author":"SM Aharony","year":"2017","journal-title":"Can Urol Assoc J"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/nau.24206","article-title":"Association between urinary symptom severity and white matter plaque distribution\n          in women with multiple sclerosis","volume":"39","author":"AL Smith","year":"2020","journal-title":"Neurourol Urodyn"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12894-020-00590-w","article-title":"Quality of life among patients with multiple sclerosis and voiding dysfunction: a\n          cross-sectional study","volume":"20","author":"F Nazari","year":"2020","journal-title":"BMC Urol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1093\/qjmed\/hch105","article-title":"What drives quality of life in multiple sclerosis?","volume":"87","author":"L Hemmett","year":"2004","journal-title":"QJM"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1007\/s00415-015-7796-2","article-title":"Epidemiology of multiple sclerosis: results from a large observational study in\n          the UK","volume":"262","author":"SS Jick","year":"2015","journal-title":"J Neurol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1002\/nau.23501","article-title":"Value of urodynamic findings in predicting upper urinary tract damage in\n          neuro-urological patients: A systematic review","volume":"37","author":"S Musco","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1177\/1352458506075651","article-title":"The neurogenic bladder in multiple sclerosis: review of the literature and\n          proposal of management guidelines","volume":"13","author":"M de S\u00e8ze","year":"2007","journal-title":"Mult Scler"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0022-5347(01)67258-6","article-title":"Relationship between lower urinary tract abnormalities and disease-related\n          parameters in multiple sclerosis","volume":"154","author":"EL Koldewijn","year":"1995","journal-title":"J Urol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12883-019-1582-1","article-title":"The prevalence of lower urinary tract symptoms based on individual and clinical\n          parameters in patients with multiple sclerosis","volume":"20","author":"F Nazari","year":"2020","journal-title":"BMC Neurol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1177\/1352458517703801","article-title":"High EDSS can predict risk for upper urinary tract damage in patients with\n          multiple sclerosis","volume":"24","author":"BV Ineichen","year":"2018","journal-title":"Mult Scler"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0022-5347(01)61760-9","article-title":"Multiple sclerosis and the urologist","volume":"161","author":"SE Litwiller","year":"1999","journal-title":"Journal of Urology"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.7224\/1537-2073.2019-030","article-title":"Prevalence of Lower Urinary Tract Symptoms in People with Multiple Sclerosis: A\n          Systematic Review and Meta-analysis","volume":"22","author":"HB Al Dandan","year":"2020","journal-title":"Int J MS Care"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s40893-017-0029-z","article-title":"Discrepancies between urinary symptoms assessment and objective bladder\n          dysfunctions in multiple sclerosis","volume":"2","author":"S Haggiag","year":"2017","journal-title":"Mult Scler Demyelinating Disord"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.ijnurstu.2011.02.002","article-title":"Bowel management related quality of life in people with multiple sclerosis:\n          psychometric evaluation of the QoL-BM measure","volume":"48","author":"EE Gulick","year":"2011","journal-title":"Int J Nurs Stud"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"105009","DOI":"10.1016\/j.msard.2023.105059","article-title":"Impact of multiple sclerosis on male sexual and reproductive health","volume":"79","author":"H Geng","year":"2023","journal-title":"Mult Scler Relat Disord"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"105011","DOI":"10.1016\/j.msard.2023.105011","article-title":"Age-related differences in the severity of sexual dysfunction symptoms and\n          psychological distress in individuals with multiple sclerosis","volume":"79","author":"D Romano","year":"2023","journal-title":"Mult Scler Relat Disord"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1186\/s12905-023-02811-4","article-title":"Reliability, validity and distribution of the Spanish female sexual function index\n          in women with relapsing multiple sclerosis","volume":"23","author":"S Gil-Perotin","year":"2023","journal-title":"BMC Womens Health"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1177\/1352458516663854","article-title":"Fatigue and fluid hydration status in multiple sclerosis: A hypothesis","volume":"22","author":"MC Cincotta","year":"2016","journal-title":"Mult Scler"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/s0022-5347(17)38581-6","article-title":"Evidence for Early Lower Urinary Tract Dysfunction in Clinically Silent Multiple\n          Sclerosis","volume":"145","author":"BL Bemelmans","year":"1991","journal-title":"Journal of Urology"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"102248","DOI":"10.1016\/j.msard.2020.102248","article-title":"Neurourological assessment in people with multiple sclerosis (MS): a new evaluated\n          algorithm","volume":"44","author":"B Domurath","year":"2020","journal-title":"Mult Scler Relat Disord"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.3390\/biomedicines10123260","article-title":"Neurogenic Lower Urinary Tract Dysfunction in Asymptomatic Patients with Multiple\n          Sclerosis","volume":"10","author":"AK Jaekel","year":"2022","journal-title":"Biomedicines"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.7224\/1537-2073.2013-040","article-title":"Lower urinary tract symptom prevalence and management among patients with multiple\n          sclerosis","volume":"17","author":"KM Khalaf","year":"2015","journal-title":"Int J MS Care"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/diagnostics12010191","article-title":"Clinical Predictors of Neurogenic Lower Urinary Tract Dysfunction in Persons with\n          Multiple Sclerosis","volume":"12","author":"J Beck","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1177\/1352458513489758","article-title":"First-line urological evaluation in multiple sclerosis: validation of a specific\n          decision-making algorithm","volume":"19","author":"G Amarenco","year":"2013","journal-title":"Mult Scler"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/nau.24230","article-title":"Urodynamics in patients with multiple sclerosis: A consensus statement from a\n          urodynamic experts working group","volume":"39","author":"MA Averbeck","year":"2020","journal-title":"Neurourol Urodyn"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/nau.22374","article-title":"Management of lower urinary tract dysfunction in multiple sclerosis: a systematic\n          review and Turkish consensus report","volume":"32","author":"B \u00c7etinel","year":"2013","journal-title":"Neurourol Urodyn"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1136\/jnnp.2008.159178","article-title":"A UK consensus on the management of the bladder in multiple sclerosis","volume":"85","author":"CJ Fowler","year":"2009","journal-title":"Postgrad Med J"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s10072-011-0794-y","article-title":"Recommendations for the management of urinary disorders in multiple sclerosis: a\n          consensus of the Italian Multiple Sclerosis Study Group","volume":"32","author":"A Ghezzi","year":"2011","journal-title":"Neurol Sci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/nau.24276","article-title":"Consensus document on the multidisciplinary management of neurogenic lower urinary\n          tract dysfunction in patients with multiple sclerosis","volume":"39","author":"J Medina-Polo","year":"2020","journal-title":"Neurourol Urodyn"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/S1474-4422(15)00070-8","article-title":"Lower urinary tract dysfunction in the neurological patient: clinical assessment\n          and management","volume":"14","author":"JN Panicker","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/nau.22673","article-title":"Patient reported outcomes measures in neurogenic bladder and bowel: A systematic\n          review of the current literature","volume":"35","author":"DP Patel","year":"2016","journal-title":"Neurourol Urodyn"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1002\/nau.23457","article-title":"Prevalence, management, and prognosis of bladder cancer in patients with\n          neurogenic bladder: A systematic review","volume":"37","author":"S Ismail","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s11255-017-1570-6","article-title":"Clinical characteristics of bladder cancer in patients with spinal cord injury:\n          the experience from a single centre","volume":"49","author":"R B\u00f6thig","year":"2017","journal-title":"Int Urol Nephrol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/nau.20941","article-title":"Pelvic floor muscle training in the treatment of lower urinary tract dysfunction\n          in women with multiple sclerosis","volume":"29","author":"AC L\u00facio","year":"2010","journal-title":"Neurourol Urodyn"},{"key":"ref42","first-page":"61","article-title":"Pelvic floor rehabilitation in multiple sclerosis","volume":"99","author":"D de Ridder","year":"1999","journal-title":"Acta Neurol Belg"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1002\/nau.20209","article-title":"Comparison of pelvic floor muscle training, electromyography biofeedback, and\n          neuromuscular electrical stimulation for bladder dysfunction in people with multiple\n          sclerosis: a randomized pilot study","volume":"25","author":"D McClurg","year":"2006","journal-title":"Neurourol Urodyn"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.eururo.2012.08.060","article-title":"Efficacy and adverse events of antimuscarinics for treating overactive bladder:\n          network meta-analyses","volume":"62","author":"N Buser","year":"2012","journal-title":"Eur Urol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.eururo.2012.02.036","article-title":"Anticholinergic drugs for adult neurogenic detrusor overactivity: a systematic\n          review and meta-analysis","volume":"62","author":"P Madhuvrata","year":"2012","journal-title":"Eur Urol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0404.2005.00431.x","article-title":"Efficacy of desmopressin in patients with multiple sclerosis suffering from\n          bladder dysfunction: a meta-analysis","volume":"112","author":"R Bosma","year":"2005","journal-title":"Acta Neurol Scand"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/nau.23921","article-title":"Desmopressin for treating nocturia in patients with multiple sclerosis: A\n          systematic review: A report from the Neuro-Urology Promotion Committee of the\n          International Continence Society (ICS)","volume":"38","author":"V Ph\u00e9","year":"2019","journal-title":"Neurourol Urodyn"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/bju.13759","article-title":"Cannabinoids for treating neurogenic lower urinary tract dysfunction in patients\n          with multiple sclerosis: a systematic review and meta-analysis","volume":"119","author":"N Abo Youssef","year":"2017","journal-title":"BJU Int"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s40618-016-0557-y","article-title":"Effects of daily tadalafil on lower urinary tract symptoms in young men with\n          multiple sclerosis and erectile dysfunction: a pilot study","volume":"40","author":"D Francomano","year":"2017","journal-title":"J Endocrinol Invest"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"104252","DOI":"10.1016\/j.msard.2022.104252","article-title":"Posterior tibial nerve stimulation as a neuromodulation therapy in treatment of\n          neurogenic overactive bladder in multiple sclerosis: A prospective randomized controlled\n          study","volume":"68","author":"MH Marzouk","year":"2022","journal-title":"Mult Scler Relat Disord"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"103392","DOI":"10.1016\/j.msard.2021.103392","article-title":"Percutaneous posterior tibial nerve stimulation (PTNS) for lower urinary tract\n          symptoms (LUTSs) treatment in patients with multiple sclerosis (MS): A systematic review\n          and meta-analysis","volume":"58","author":"F Guitynavard","year":"2022","journal-title":"Mult Scler Relat Disord"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s12325-021-01650-9","article-title":"Systematic Literature Review and Meta-Analysis of Sacral Neuromodulation (SNM) in\n          Patients with Neurogenic Lower Urinary Tract Dysfunction (nLUTD): Over 20 Years'\n          Experience and Future Directions","volume":"38","author":"A van Ophoven","year":"2021","journal-title":"Adv Ther"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/nau.23291","article-title":"Switch to Abobotulinum toxin A may be useful in the treatment of neurogenic\n          detrusor overactivity when intradetrusor injections of Onabotulinum toxin A\n          failed","volume":"37","author":"F Bottet","year":"2018","journal-title":"Neurourol Urodyn"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e657","DOI":"10.1212\/WNL.0000000000005991","article-title":"Low-dose onabotulinumtoxinA improves urinary symptoms in noncatheterizing patients\n          with MS","volume":"91","author":"M Tullman","year":"2018","journal-title":"Neurology"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.euf.2021.08.007","article-title":"Efficacy and Safety of Surgical Treatments for Neurogenic Stress Urinary\n          Incontinence in Adults: A Systematic Review","volume":"8","author":"S Musco","year":"2022","journal-title":"Eur Urol Focus"}],"container-title":["Aktuelle Urologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2281-7924.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:16:15Z","timestamp":1730826975000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2281-7924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":49,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2024,7,24]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2281-7924","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0001-7868","1438-8820"],"issn-type":[{"type":"print","value":"0001-7868"},{"type":"electronic","value":"1438-8820"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}