{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:06:34Z","timestamp":1771643194013,"version":"3.50.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to examine whether the addition of latency antibiotics in late preterm rupture of membranes (ROM) decreases neonatal infection and increases latency.<\/jats:p><jats:p>\n            Study Design\u2003This retrospective two-center study was conducted at Holy Family Hospital (HFH) in Nazareth and Emek Medical Center (EMC) in Afula, on data collected between January 2017 and April 2023. HFH is the smaller institution. EMC and HFH implement similar policies regarding ROM at 340\/7 to 366\/7 weeks' gestation; the only difference is that a 10-day course of latency antibiotics is implemented at EMC. All women with ROM between 340\/7 and 366\/7 weeks' gestation who were admitted to one of the centers during the study period, and had a live fetus without major malformations, were included. The primary outcome was neonatal sepsis rate. Secondary outcomes included a composite of neonatal sepsis, mechanical ventilation \u226524\u2009hours, and perinatal death. Additionally, gestational age at delivery and delivery mode were examined.<\/jats:p><jats:p>\n            Results\u2003Overall, 721 neonates were delivered during the study period: 534 at EMC (where latency antibiotics were administered) and 187 at HFH. The gestational age at ROM was similar (35.8 and 35.9 weeks, respectively, p\u2009=\u20090.14). Neonatal sepsis occurred in six (1.1%) neonates at EMC and one (0.5%) neonate at HFH (adjusted p\u2009=\u20090.71; OR: 1.69; 95% Confidence Interval [CI]: 0.11\u201327.14). The composite secondary outcome occurred in nine (1.7%) and three (1.6%) neonates at EMC and HFH, respectively (adjusted p\u2009=\u20090.71; OR: 0.73; 95% CI: 0.14\u20133.83). The gestational age at delivery was 36.1 and 36.2 weeks at EMC and HFH, respectively (mean difference: 5\u2009h; adjusted p\u2009=\u20090.02). The cesarean delivery rate was 24.7% and 19.3% at EMC and HFH, respectively (adjusted p\u2009=\u20090.96).<\/jats:p><jats:p>\n            Conclusion\u2003Latency antibiotics administered to women admitted with ROM between 340\/7 and 366\/7 weeks' gestation did not decrease the rate of neonatal sepsis.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2282-9072","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T23:51:53Z","timestamp":1709855513000},"page":"1965-1972","source":"Crossref","is-referenced-by-count":3,"title":["Perinatal Outcomes of Late Preterm Rupture of Membranes with or without Latency Antibiotics"],"prefix":"10.1055","volume":"41","author":[{"given":"Mais","family":"Abu Nofal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal","family":"Massalha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysa","family":"Abboud","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Asla Jamhour","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waseem","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Holy Family Hospital, Nazareth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Talmon","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emek Medical Center, Afula, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samah","family":"Mresat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Mattar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gali","family":"Garmi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Zafran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Reiss","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raed","family":"Salim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Holy Family Hospital, Nazareth, Israel"},{"name":"Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"issue":"S 01","key":"ref1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1471-0528.2005.00582.x","article-title":"Preterm premature rupture of membranes: diagnosis, evaluation and management strategies","volume":"112","author":"H N Simhan","year":"2005","journal-title":"BJOG"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/0002-9378(91)90707-X","article-title":"Progress in pathogenesis and management of clinical intraamniotic infection","volume":"164","author":"R S Gibbs","year":"1991","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref3","first-page":"417","article-title":"Premature rupture of membranes and preterm labor: neonatal infection and perinatal mortality risks","volume":"58","author":"N H Daikoku","year":"1981","journal-title":"Obstet 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