{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:16:45Z","timestamp":1790108205340,"version":"4.0.1"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malignant schwannomas of the visceral organs are extremely rare. To date, 19 cases of cervical schwannoma have been reported in the literature worldwide. A single case prompted a review of the literature. The differential diagnosis between melanoma and schwannoma is made using the marker HMB-45, which is positive for melanoma and negative for schwannoma. This differentiation allowed us to identify two of the 20 cases that were probably not schwannomas.<\/jats:p>\n                  <jats:p>The prognosis of malignant cervical schwannoma is poor. Approximately half of the cases develop local recurrence or distant metastases within a short time, despite resection in healthy tissue.<\/jats:p>\n                  <jats:p>In one case, gene sequencing revealed a potential treatment approach with the mTOR inhibitor everolimus and trastuzumab. Unfortunately, the potential efficacy of these treatment options could not be tested because the patient was being treated at another hospital at the time of relapse, and they did not use a drug that matched the NGS profile.<\/jats:p>","DOI":"10.1055\/a-2283-3714","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T19:00:21Z","timestamp":1733857221000},"page":"395-404","source":"Crossref","is-referenced-by-count":2,"title":["Malignant Peripheral Nerve Sheath Tumor (MPNST) of the Uterine Cervix \u2013 A Systematic Literature Review and New Case Report with Possible New Therapeutic Approaches"],"prefix":"10.1055","volume":"85","author":[{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Gynecology and Breast Cancer, Southwest Medical University School of Clinical Medical Sciences, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Min","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Preclinical Medicine, Southwest Medical University School of Clinical Medical Sciences, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Pathology Department, Southwest Medical University School of Clinical Medical Sciences, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Gynecology and Breast Cancer, Southwest Medical University School of Clinical Medical Sciences, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Christoph","family":"Schwenzer","sequence":"additional","affiliation":[{"name":"Gynecology and Breast Cancer, Southwest Medical University School of Clinical Medical Sciences, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1038\/s41388-022-02290-1","article-title":"Malignant peripheral nerve sheath tumor: models, biology, and translation","volume":"41","author":"BN Somatilaka","year":"2022","journal-title":"Oncogene"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1470-2045(08)70074-3","article-title":"Classification of radical hysterectomy","volume":"9","author":"D Querleu","year":"2008","journal-title":"Lancet Oncol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1093\/neuros\/nyab021","article-title":"Diagnostic Pathology of Tumors of Peripheral Nerve","volume":"88","author":"SM Belakhoua","year":"2021","journal-title":"Neurosurgery"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1002\/pbc.25149","article-title":"Malignant peripheral nerve sheath tumors (MPNST): a SEER analysis of incidence across the age spectrum and therapeutic interventions in the pediatric population","volume":"61","author":"JE Bates","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1007\/s00381-020-04687-3","article-title":"Treatment of malignant peripheral nerve sheath tumors in pediatric NF1 disease","volume":"36","author":"E Martin","year":"2020","journal-title":"Childs Nerv Syst"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s40792-023-01733-5","article-title":"Malignant peripheral nerve sheath tumor in the pelvis: a case report","volume":"9","author":"R Ono","year":"2023","journal-title":"Surg Case Rep"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1309\/V8XM-K5R7-8Q96-V090","article-title":"Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis","volume":"124","author":"KH Allison","year":"2005","journal-title":"Am J Clin Pathol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1477-7819-7-12","article-title":"Diagnosis and management of retroperitoneal ancient schwannomas","volume":"7","author":"HA Choudry","year":"2009","journal-title":"World J Surg Oncol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"vdaa131","DOI":"10.1093\/noajnl\/vdaa131","article-title":"Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival","volume":"2","author":"CG Lucas","year":"2020","journal-title":"Neurooncol Adv"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/s0002-9378(88)80145-5","article-title":"Diagnosis of a tumor with an unusual presentation in the pelvis","volume":"159","author":"D Sloan","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1471-0528.1989.tb01587.x","article-title":"Primary malignant Schwannoma of the uterine cervix. 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