{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:14:05Z","timestamp":1749615245879,"version":"3.41.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Einleitung Bei fehlender Wirksamkeit antikonvulsiver Medikamente stellen\n                    epilepsiechirurgische Eingriffe eine effektive Ma\u00dfnahme dar, um Anfallsfreiheit\n                    zu erreichen. Um negative Auswirkungen operativer Eingriffe auf kognitive\n                    Funktionen zu vermeiden, sind bei Patienten mit spezifischem Risikoprofil\n                    neurorehabilitative Ma\u00dfnahmen erforderlich. Diese Studie verfolgte das Ziel, zu\n                    identifizieren, bei welchen Patienten ein erh\u00f6htes Risiko f\u00fcr postoperative\n                    neurokognitive Verschlechterungen besteht und welche Ma\u00dfnahmen den\n                    postoperativen Rehabilitationsverlauf positiv unterst\u00fctzen.<\/jats:p><jats:p>\n          Methode In einer prospektiven Studie wurden Patientengruppen mit\n                    epilepsiechirurgischen Eingriffen im linken bzw. rechten Temporallappen\n                    verglichen. Die kognitive Leistungsf\u00e4higkeit der Patienten wurde pr\u00e4operativ und\n                    sechs Monate postoperativ erfasst. Bei 35 Patienten, bei denen der\n                    epilepsiechirurgische Eingriff im linken Temporallappen erfolgt ist, wurde eine\n                    Risikostratifizierung bez\u00fcglich postoperativer kognitiver Verschlechterungen\n                    vorgenommen. Aus dieser Gruppe wurden sieben Patienten selektiert, die ein\n                    spezifisches Risikoprofil aufwiesen: Sprach- und Ged\u00e4chtnisdominanz links,\n                    geringe funktionelle Kapazit\u00e4t der kontralateralen Hemisph\u00e4re und pr\u00e4operative\n                    neuropsychologische Defizite. Diese Gruppe wurde nach der Operation \u00fcber einen\n                    Zeitraum von sechs Monaten neuropsychologisch trainiert. Als Kontrollgruppe\n                    dienten Patienten mit Operation im rechten Temporallappen, die keine Therapie\n                    erhielten. <\/jats:p><jats:p>\n          Ergebnisse Postoperativ zeigten sich f\u00fcr Patienten mit rechtstemporalen\n                    Eingriffen keine wesentlichen Leistungsverschlechterungen. Nach linkstemporalen\n                    Eingriffen traten merkliche Beeintr\u00e4chtigungen im Benennen auf. Die\n                    therapeutisch angebundenen Patienten zeigten ausgepr\u00e4gte sprachassoziierte\n                    Defizite (Benennen, Verbalged\u00e4chtnis), die sich im Verlauf der Therapie\n                    besserten.<\/jats:p><jats:p>\n          Schlussfolgerung Durch eine fr\u00fche neurorehabilitative Anbindung kann das\n                    Auftreten postoperativer kognitiver Funktionseinbu\u00dfen minimiert werden. <\/jats:p>","DOI":"10.1055\/a-2284-0431","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T23:30:15Z","timestamp":1713915015000},"page":"223-229","source":"Crossref","is-referenced-by-count":1,"title":["Anforderungen an die Neurorehabilitation nach epilepsiechirurgischen\n                    Eingriffen im linken Temporallappen bei Patienten mit neurokognitivem\n                    Risikoprofil"],"prefix":"10.1055","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-1416","authenticated-orcid":false,"given":"Michael","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Epilepsiezentrum Erlangen, Universitatsklinikum\n                    Erlangen Neurologische Klinik, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabell Sophie","family":"Badst\u00fcbner","sequence":"additional","affiliation":[{"name":"Epilepsiezentrum Erlangen, Universitatsklinikum\n                    Erlangen Neurologische Klinik, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karlotta","family":"Meyn","sequence":"additional","affiliation":[{"name":"Epilepsiezentrum Erlangen, Universitatsklinikum\n                    Erlangen Neurologische Klinik, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Walther","sequence":"additional","affiliation":[{"name":"Epilepsiezentrum Erlangen, Universitatsklinikum\n                    Erlangen Neurologische Klinik, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajo","family":"Hamer","sequence":"additional","affiliation":[{"name":"Epilepsiezentrum Erlangen, Universitatsklinikum\n                    Erlangen Neurologische Klinik, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.21037\/apm-20-1415","article-title":"Factors influencing the long-term prognosis of patients with temporal lobe\n                    epilepsy: a single center study","volume":"9","author":"L Yang","year":"2020","journal-title":"Ann Palliat Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s001150050639","article-title":"Temporallappenepiliepsie: L\u00e4ngsschnittliche klinische, neuropsychlogische und\n                    psychosoziale Entwicklung operativer und konservativ behandelter Patienten","volume":"71","author":"C Helmstaedter","year":"2000","journal-title":"Der Nervenarzt"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1093\/brain\/awu100","article-title":"Differential influence of hippocampal subfields to memory formation: insights\n                    from patients with temporal lobe epilepsy","volume":"137","author":"R Coras","year":"2014","journal-title":"Brain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1016\/S0140-6736(05)74765-6","article-title":"Cognitive impairment in temporal-lobe epilepsy","volume":"355","author":"H Jokeit","year":"2000","journal-title":"The Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1212\/wnl.30.2.120","article-title":"Interictal memory and language impairment in temporal lobe epilepsy","volume":"30","author":"R Mayeux","year":"1980","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1159\/000007981","article-title":"Comprehensive postictal neuropsychology improves focus localization in\n                    epilepsy","volume":"40","author":"A Pegna","year":"1998","journal-title":"European Neurology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s10309-010-0100-7","article-title":"Sprachdiagnostik bei Patienten mit unilateraler Temporallappenepilepsie. 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