{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:38:09Z","timestamp":1764221889730,"version":"3.46.0"},"reference-count":143,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Zum Nachweis von Infektionskrankheiten existieren neben den in kommerziellen\n                    Laboratorien durchf\u00fchrbaren Verfahren auch sogenannte Point-of-care- (POC-) oder\n                    In-house-Tests. Diese basieren auf einem Enzyme-Linked Immunosorbent Assay\n                    (ELISA) oder anderen immunchromatografischen Testprinzipien und liefern binnen\n                    weniger Minuten direkt vor Ort ein Testergebnis. Dieser Artikel gibt einen\n                    \u00dcberblick \u00fcber die Qualit\u00e4t der zahlreichen POC-Tests verschiedener Hersteller\n                    zum Nachweis von Parvovirus-Antigen im Kot, Antigen von Dirofilaria (D.)\n                        immitis im Blut sowie zum Nachweis von Antik\u00f6rpern gegen Borrelia\n                        (B.) burgdorferi, Anaplasma (A.) spp., Ehrlichia\n                        (E.) spp., Leptospira (L.) spp. und Leishmania (L.)\n                        infantum im Blut (einzeln oder in Kombinationen). Entscheidend f\u00fcr den\n                    Nutzen der Tests sind ihre Sensitivit\u00e4t und Spezifit\u00e4t. Auch muss das\n                    Vorhandensein von Antik\u00f6rpern oder der Nachweis von Antigen mit dem Auftreten\n                    einer klinischen Erkrankung einhergehen. POC-Tests zum Nachweis von\n                    Parvovirus-Antigen im Kot besitzen zwar eine sehr hohe Spezifit\u00e4t, die\n                    Sensitivit\u00e4t aller evaluierten Tests ist jedoch sehr niedrig. Die POC-Tests zum\n                    Nachweis von D. immitis besitzen eine sehr hohe Sensitivit\u00e4t und\n                    Spezifit\u00e4t. Da sie Antigen aus dem Uterus adulter, weiblicher Tiere nachweisen,\n                    ist der Test jedoch negativ, wenn keine oder zu wenig adulte, weibliche\n                    Dirofilarien vorhanden sind. Der POC-Test zum Nachweis von\n                        B.-burgdorferi-Antik\u00f6rpern zeigt nur den Erregerkontakt an und\n                    nicht die klinische Erkrankung, da das Auftreten von Antik\u00f6rpern nur in\n                    seltensten F\u00e4llen mit einer Erkrankung einhergeht. Ebenso ist der POC-Test zum\n                    Nachweis von Antik\u00f6rpern gegen A. phagocytophilum zur Diagnose einer\n                    klinischen Anaplasmose ungeeignet, da auch diese Infektion nur selten zur\n                    Erkrankung f\u00fchrt und wenn, dann Symptome in der Regel vor Ausbildung der\n                    Antik\u00f6rper auftreten. Zum Nachweis von Antik\u00f6rpern gegen E. canis zeigen\n                    die POC-Tests eine sehr hohe Sensitivit\u00e4t und Spezifit\u00e4t. POC-Tests zum Nachweis\n                    von Antik\u00f6rpern gegen L. infantum und Leptospira-Spezies (spp.)\n                    besitzen ebenfalls eine sehr hohe Spezifit\u00e4t und eine hohe Sensitivit\u00e4t. Jedoch\n                    kann es bei Letzteren zu positiven Ergebnissen nach einer Impfung kommen, da die\n                    Tests nicht zwischen Feld- und Impfantik\u00f6rpern unterscheiden k\u00f6nnen.<\/jats:p>","DOI":"10.1055\/a-2289-1927","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T18:35:16Z","timestamp":1714761316000},"page":"98-109","source":"Crossref","is-referenced-by-count":0,"title":["\u00dcbersicht \u00fcber Einsatzm\u00f6glichkeiten von In-house-Tests zum Nachweis\n                    von systemischen Infektionskrankheiten beim Hund"],"prefix":"10.1055","volume":"52","author":[{"given":"Julia","family":"Walter-Weing\u00e4rtner","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Ludwig-Maximilians-Universit\u00e4t\n                    M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Ludwig-Maximilians-Universit\u00e4t\n                    M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Ludwig-Maximilians-Universit\u00e4t\n                    M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1055\/s-0037-1622411","article-title":"Diagnostik und Therapie von Reisekrankheiten beim Hund","volume":"32","author":"P Beelitz","year":"2004","journal-title":"Tierarztl Prax Ausg K Kleintiere 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