{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:37:08Z","timestamp":1790303828676,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral ulcerative keratitis (PUK) is an inflammatory disease of the peripheral cornea, which may frequently be associated with several rare, but potentially life-threatening systemic diseases. The inflammatory pathogenesis of PUK results from humoral and cell-mediated inflammation. The diagnosis is usually based on the typical clinical findings and always requires detailed diagnostic testing to identify a potential systemic underlying disease. Treatment includes topical and systemic immunosuppressive and immunomodulatory therapeutic strategies and, in the event of impending or existing perforation, also various surgical interventions. PUK is a potentially blinding disease that initially affects the periphery, but, if left untreated, can lead to destruction of the entire cornea. Interdisciplinary diagnostic testing and therapy are crucial to preserve vision in the affected patients and reduce morbidity and mortality. The following article provides an overview of the\n          pathophysiology, clinical findings, possible underlying systemic diseases, relevant differential diagnoses and therapeutic strategies.<\/jats:p>","DOI":"10.1055\/a-2290-4420","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T18:34:11Z","timestamp":1716402851000},"page":"633-643","source":"Crossref","is-referenced-by-count":2,"title":["Peripheral Ulcerative Keratitis: Clinical Characteristics, Differential Diagnoses and Therapeutic Concepts"],"prefix":"10.1055","volume":"241","author":[{"given":"Karoline","family":"Baquet-Walscheid","sequence":"additional","affiliation":[{"name":"Augenzentrum am St.\u00a0Franziskus-Hospital M\u00fcnster, Deutschland"},{"name":"Medizinische Fakult\u00e4t, Universit\u00e4t Duisburg-Essen, Essen, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ne\u00df","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Christian","family":"Maier","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabo","family":"Lapp","sequence":"additional","affiliation":[{"name":"Augenzentrum am St.\u00a0Franziskus-Hospital M\u00fcnster, Deutschland"},{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum Freiburg, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/ICU.0000000000000895","article-title":"Peripheral ulcerative keratitis due to systemic diseases","volume":"33","author":"A A Sura","year":"2022","journal-title":"Curr Opin 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