{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:14:23Z","timestamp":1782422063067,"version":"3.54.5"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n            Hintergrund Die Indikation zur elektiven Neck Dissection (END) bei Patienten mit T1\/2-Plattenepithelkarzinomen des Hypopharynx (HPSCC) und Oropharynx (OPSCC) wird nicht einheitlich gestellt. In der vorliegenden Studie erfolgte daher eine detaillierte Analyse des Metastasierungsverhaltens von HPSCC und OPSCC.<\/jats:p><jats:p>\n            Material und Methoden Es erfolgte eine multizentrische retrospektive Analyse des nodalen Metastasierungsverhaltens und der onkologischen Parameter von 262 chirurgisch therapierten HPSCC- und OPSCC-Patienten. Zudem erfolgte eine systematische Literaturrecherche.<\/jats:p><jats:p>\n            Ergebnisse Bei HPSCC-Patienten lag in 62,1% der F\u00e4lle eine Diskrepanz zwischen klinischem und pathologischem N-Status vor, bei OPSCC in 52,4% (p16-) bzw. 43,6% (p16+). Die okkulte Metastasierungsrate in den Prim\u00e4rtumorstadien T1\/2 lag dabei bei 38,9% f\u00fcr HPSCC und bei 17,8% (p16-) und 11,1% (p16+) f\u00fcr OPSCC. Bei HPSCC traten in den Stadien cT1\/2cN0 in 22,2% der F\u00e4lle kontralaterale Metastasen auf; die Rate bei OPSCC lag bei lediglich 9,1% (p16-) bzw. 0% (p16+). Patienten mit p16-positiven OPSCC wiesen ein besseres rezidivfreies und Gesamt\u00fcberleben auf als p16-negative OPSCC- und HPSCC-Patienten. Ein direkter Zusammenhang zwischen Patienten\u00fcberleben und Ausma\u00df der chirurgischen Therapie des Halses lie\u00df sich nicht nachweisen.<\/jats:p><jats:p>\n            Schlussfolgerung Patienten mit HPSCC weisen ab Stadium cT1\/2cN0 ein hohes Risiko f\u00fcr okkulte Halslymphknotenmetastasen auf, welches die Durchf\u00fchrung einer beidseitigen END rechtfertigt. Bei Patienten mit T1\/2cN0-OPSCC manifestieren sich ipsilateral in &gt;20% der F\u00e4lle okkulte Metastasen; das Risiko f\u00fcr eine kontralaterale okkulte Metastasierung liegt jedoch bei &lt;10%, sodass bei streng lateralisierten Tumoren ein Verzicht auf die kontralaterale Neck Dissection erwogen werden kann.<\/jats:p>","DOI":"10.1055\/a-2291-9979","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T22:53:00Z","timestamp":1717455180000},"page":"842-854","source":"Crossref","is-referenced-by-count":2,"title":["Nodale Metastasierung und Stellenwert der Neck Dissection bei T1\/2-Oro- und Hypopharynxkarzinomen"],"prefix":"10.1055","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-0797","authenticated-orcid":false,"given":"Eric","family":"Deu\u00df","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius H.L.","family":"K\u00fcrten","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Meyer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph Raphael","family":"Buhr","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ernst","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Mattheis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Lang","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timon","family":"Hussain","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universit\u00e4tsklinikum Essen, Essen, Germany"},{"name":"Klinik f\u00fcr Hals-, Nasen-, Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/1097-0347(200007)22:4<380::AID-HED11>3.0.CO;2-E","article-title":"Cervical node metastases in laryngeal and hypopharyngeal cancer: a prospective analysis of prevalence and distribution","volume":"22","author":"JG Buckley","year":"2000","journal-title":"Head Neck"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/s1808-8694(15)30485-7","article-title":"Indication of elective contralateral neck dissection in squamous cell carcinoma of the hypopharynx","volume":"75","author":"A Amar","year":"2009","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3109\/00016489.2011.554437","article-title":"Necessity of level IV dissection in cN0 hypopharyngeal carcinoma","volume":"131","author":"YS Shin","year":"2011","journal-title":"Acta Otolaryngol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.anorl.2016.10.004","article-title":"Review of sentinel node procedure in cN0 head and neck squamous cell carcinomas. 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