{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:20:18Z","timestamp":1790612418483,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["305742\/2022-1"],"award-info":[{"award-number":["305742\/2022-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"crossref","award":["83\/013.186\/2023"],"award-info":[{"award-number":["83\/013.186\/2023"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Traditional medicine is a frequently utilized method to treat cardiovascular disease and its primary risk factors, including hypertension and dyslipidemia. Aloysia polystachya is a species that is commonly employed to treat various pathological conditions, and it has already been identified as having some cardioprotective effects. This study aimed to investigate the protective effects of the essential oil extracted from the leaves of A.\u00a0polystachya in a rat model that simulates multiple cardiovascular risk factors. We evaluate the acute toxicity, as well as the cardioprotective effects, by giving different doses of A.\u00a0polystachya essential oil (1.47\u2009mg\/kg, 4.40\u2009mg\/kg, and 13.20\u2009mg\/kg) over a period of 42 days. The control group was treated with rosuvastatin (5\u2009mg\/kg). At the end of the treatments, the renal function, electrocardiography, blood pressure, vascular reactivity, serum biochemical profile, and organ histopathology were evaluated. The main compounds identified in\n          the essential oil of A.\u00a0polystachya using gas chromatography coupled with mass spectrometry were beta-myrcene (1.08%), limonene (40.13%), and carvone (56.47%). The essential oil of A.\u00a0polystachya not only lacks acute toxicity but also mitigates the reduction in the excretion of sodium, chloride, and creatinine in urine. Furthermore, it reduces electrocardiographic abnormalities and decreases blood pressure levels. Moreover, this treatment prevents an elevation in markers of inflammation and oxidative stress in the bloodstream. Our findings indicate significant cardioprotective effects of the essential oil of A.\u00a0polystachya against multiple risk factors for cardiovascular diseases in hypertensive rats.<\/jats:p>","DOI":"10.1055\/a-2294-6922","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T22:47:51Z","timestamp":1713394071000},"page":"708-716","source":"Crossref","is-referenced-by-count":5,"title":["Cardioprotective Effects of Aloysia polystachya Essential Oil on a Rat Model with Multiple Cardiovascular Risk Factors"],"prefix":"10.1055","volume":"90","author":[{"given":"Karyne Garcia Tafarelo","family":"Moreno","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Aparecida Macedo","family":"Marques","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Pereira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Ale","family":"Bertoncelo","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane Barbosa","family":"Pessoal","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Dantas","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariany Carvalho","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Histopathology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosevelt Isa\u00edas Carvalho","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Histopathology, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Brentan","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Products and Mass Spectrometry (LAPNEM), Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":false,"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Pharmacology (LaFAC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"G A 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Physiol"}],"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2294-6922.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:23:48Z","timestamp":1730805828000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2294-6922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":33,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2024,7,17]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2294-6922","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]}}}