{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T19:31:53Z","timestamp":1768764713715,"version":"3.49.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n            Objective\u2003The ductus arteriosus normally closes after birth. Histamine 2 receptor antagonist (H2RA) has been associated with patent ductus arteriosus (PDA). We aimed to study the characteristics of term infants with PDA and their possible association with prenatal exposure to antacids\u2014proton pump inhibitors (PPIs) and H2RA.<\/jats:p><jats:p>\n            Study Design\u2003This was a population-based matched case\u2013control study of mothers registered at \u201cClalit\u201d Health Maintenance Organization (HMO) and their infants born at \u201cSoroka\u201d University Medical Center (SUMC) between 2001 and 2018. Cases are defined as term infants born with PDA diagnosed by echocardiography and registered in the postdelivery discharge form. Each case was matched with four term newborns without PDA diagnosis. Exposure window was defined by the timing of first purchase of H2RA or PPI during pregnancy and based on information from a computerized medication database (Clalit HMO, SUMC).<\/jats:p><jats:p>\n            Results\u2003PDA was diagnosed in 1,884 term infants (4.9%). Characteristics included a significantly higher percentage of lack of prenatal care, cesarean section, in vitro fertilization, polyhydramnios, oligohydramnios, Apgar 1\u2009minute &lt;5, and prenatal exposure to H2RA (odds ratio [OR] 4.18) and PPIs (OR 3.50; all p\u2009&lt;\u20090.001). PDA association with exposure window was similar in each trimester (1.5\u20132%) for both H2RA and PPI.<\/jats:p><jats:p>\n            Conclusion\u2003PDA incidence in term infants in our population was greater than previously reported. PPI and H2RA are both antiacids with different mechanisms of action. The similar OR for exposure to one as well as the other, and the lack of influence of the initial exposure period, are compatible with bias.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2295-6339","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:17:13Z","timestamp":1711585033000},"page":"2091-2097","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal Exposure to Acid Suppressor Medications and Development of Ductus Arteriosus in Term Newborns"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5905-4316","authenticated-orcid":false,"given":"Ella","family":"Segal","sequence":"additional","affiliation":[{"name":"Joyce and Irving Goldman Medical School, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior","family":"Hassan","sequence":"additional","affiliation":[{"name":"Joyce and Irving Goldman Medical School, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adir","family":"Israeli","sequence":"additional","affiliation":[{"name":"Joyce and Irving Goldman Medical School, The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Gorodischer","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/adc.62.10.1030","article-title":"Ductus arteriosus blood flow during first 48\u2009hours of life","volume":"62","author":"M R Drayton","year":"1987","journal-title":"Arch Dis Child"},{"issue":"02","key":"ref2","first-page":"137","article-title":"The pharmacology of the ductus arteriosus","volume":"49","author":"G C Smith","year":"1997","journal-title":"Pharmacol Rev"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1093\/cvr\/27.12.2205","article-title":"Characterisation of the effect of oxygen tension on response of fetal rabbit ductus arteriosus to vasodilators","volume":"27","author":"G CS Smith","year":"1993","journal-title":"Cardiovasc 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