{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:08:12Z","timestamp":1784383692330,"version":"3.55.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"15","funder":[{"name":"National Institute of General Medical Sciences of the National Institutes of Health","award":["5U54GM115428"],"award-info":[{"award-number":["5U54GM115428"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to identify the clinical and growth parameters associated with retinopathy of prematurity (ROP) in infants with necrotizing enterocolitis (NEC) and spontaneous ileal perforation (SIP).<\/jats:p><jats:p>\n            Study Design\u2003We conducted a retrospective cohort study that compared clinical data before and after NEC\/SIP onset in neonates, categorizing by any ROP and severe ROP (type 1\/2) status.<\/jats:p><jats:p>\n            Results\u2003The analysis included 109 infants with surgical NEC\/SIP. Sixty infants (60\/109, 55%) were diagnosed with any ROP, 32\/109 (29.3%) infants (22% type 1 and 7.3% type 2) with severe ROP. On univariate analysis, those with severe ROP (32\/109, 39.5%) were of lower median gestational age (GA, 23.8 weeks [23.4, 24.6] vs. 27.3 [26.3, 29.0], p\u2009&lt;\u20090.001), lower median birth weight (625\u2009g [512, 710] vs. 935 [700, 1,180], p\u2009&lt;\u20090.001) and experienced higher exposure to clinical chorioamnionitis (22.6 vs. 2.13%, p\u2009&lt;\u20090.006), and later median onset of ROP diagnosis (63.0 days [47.0, 77.2] vs. 29.0 [19.0, 41.0], p\u2009&lt;\u20090.001), received Penrose drain placement more commonly (19 [59.4%] vs. 16 [34.0%], p\u2009=\u20090.04), retained less residual small bowel (70.0\u2009cm [63.1, 90.8] vs. 90.8 [72.0, 101], p\u2009=\u20090.007) following surgery, were exposed to higher FiO2 7 days after birth (p\u2009=\u20090.001), received ventilation longer and exposed to higher FiO2 at 2 weeks (p\u2009&lt;\u20090.05) following NEC and developed acute kidney injury (AKI) more often (25 [86.2%] vs. 20 [46.5%], p\u2009=\u20090.002) than those without ROP. Those with severe ROP had lower length, weight for length, and head circumference z scores. In an adjusted Firth's logistic regression, GA (adjusted odds ratio [aOR]\u2009=\u20090.51, 95% confidence interval [CI]: [0.35, 0.76]) and diagnosis at later age (aOR\u2009=\u20091.08, 95% CI: [1.03, 1.13]) was shown to be significantly associated with any ROP.<\/jats:p><jats:p>\n            Conclusion\u2003Infants who develop severe ROP following surgical NEC\/SIP are likely to be younger, smaller, have been exposed to more O2, develop AKI, and grow poorly compared with those did not develop severe ROP.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2297-8644","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T23:47:14Z","timestamp":1712101634000},"page":"2152-2164","source":"Crossref","is-referenced-by-count":10,"title":["Clinical and Growth Correlates of Retinopathy of Prematurity in Preterm Infants with Surgical Necrotizing Enterocolitis and Intestinal Perforation"],"prefix":"10.1055","volume":"41","author":[{"given":"Parvesh M.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology, Atrium Health Wake Forest Baptist, Wake Forest School of Medicine, Winston Salem, North Carolina"},{"name":"Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A.","family":"Riddick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md A.Y.","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Data Sciences, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha C.","family":"Meilstrup","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zepponi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Mungan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Shenberger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Neonatology, Connecticut Children's, Hartford, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Hillegass","sequence":"additional","affiliation":[{"name":"Department of Data Sciences, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma P.","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"J Neu","year":"2011","journal-title":"N Engl J 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