{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:09:50Z","timestamp":1776823790135,"version":"3.51.2"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1055\/a-2301-8259","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:55:38Z","timestamp":1742000138000},"page":"371-384","source":"Crossref","is-referenced-by-count":1,"title":["Akutes Leberversagen"],"prefix":"10.1055","volume":"150","author":[{"given":"Natascha","family":"R\u00f6hlen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jhep.2016.12.003","article-title":"EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure","volume":"66","author":"European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, Clinical practice guidelines panel, Wendon J et al","year":"2017","journal-title":"J Hepatol"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jhep.2023.04.021","article-title":"EASL Clinical Practice Guidelines on acute-on-chronic liver failure","volume":"79","author":"European Association for the Study of the Liver","year":"2023","journal-title":"J Hepatol"},{"issue":"02","key":"ref3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000492869","article-title":"How to Define Acute Liver Failure Patients with Pre-Existing Liver Disease without Signs of Cirrhosis","volume":"37","author":"A Gottlieb","year":"2019","journal-title":"Dig Dis"},{"issue":"04","key":"ref4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3238\/arztebl.2020.0043","article-title":"The Epidemiology of Acute Liver Failure","volume":"117","author":"N Weiler","year":"2020","journal-title":"Dtsch Arztebl Int"},{"issue":"02","key":"ref5","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.jhep.2012.03.017","article-title":"Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database","volume":"57","author":"G Germani","year":"2012","journal-title":"J Hepatol"},{"issue":"9736","key":"ref6","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"W Bernal","year":"2010","journal-title":"Lancet"},{"issue":"06","key":"ref7","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.cgh.2012.02.016","article-title":"Etiologies and outcomes of acute liver failure in Germany","volume":"10","author":"J Hadem","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"ref8","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1155\/2002\/328415","article-title":"Etiology and outcome of acute liver failure: experience from a liver transplantation centre in Montreal","volume":"16","author":"G Tessier","year":"2002","journal-title":"Can J Gastroenterol"},{"issue":"06","key":"ref9","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","author":"AM Larson","year":"2005","journal-title":"Hepatology"},{"issue":"02","key":"ref10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1365-2036.2011.04687.x","article-title":"The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose","volume":"34","author":"DGN Craig","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"issue":"42","key":"ref11","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3238\/arztebl.2011.0714","article-title":"Acute liver failure: a life-threatening disease","volume":"108","author":"A Canbay","year":"2011","journal-title":"Dtsch Arztebl Int"},{"issue":"02","key":"ref12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-2125.2011.04067.x","article-title":"Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity","volume":"73","author":"DGN Craig","year":"2012","journal-title":"Br J Clin Pharmacol"},{"issue":"06","key":"ref13","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.jhep.2019.02.014","article-title":"EASL Clinical Practice Guidelines: Drug-induced liver injury","volume":"70","author":"European Association for the Study of the Liver; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative","year":"2019","journal-title":"J Hepatol"},{"issue":"01","key":"ref14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/HEP.0000000000000045","article-title":"Checkpoint inhibitor hepatotoxicity: pathogenesis and management","volume":"79","author":"M Cunningham","year":"2024","journal-title":"Hepatology"},{"issue":"04","key":"ref15","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1097\/HEP.0000000000000458","article-title":"Future directions in acute liver failure","volume":"78","author":"RT Stravitz","year":"2023","journal-title":"Hepatology"},{"issue":"01","key":"ref16","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s10620-022-07524-6","article-title":"Role of Hepatitis C Infection in Acute Liver Injury\/Acute Liver Failure in North America","volume":"68","author":"A Rao","year":"2023","journal-title":"Dig Dis Sci"},{"issue":"10","key":"ref17","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1016\/j.cgh.2015.04.014","article-title":"Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in Europe","volume":"13","author":"P Manka","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"03","key":"ref18","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.jhep.2023.03.006","article-title":"EASL Clinical Practice Guidelines on the management of liver diseases in pregnancy","volume":"79","author":"European Association for the Study of the Liver","year":"2023","journal-title":"J Hepatol"},{"issue":"03","key":"ref19","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jhep.2011.11.007","article-title":"EASL Clinical Practice Guidelines: Wilson\u2019s disease","volume":"56","author":"European Association for Study of Liver","year":"2012","journal-title":"J Hepatol"},{"issue":"01","key":"ref20","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s00134-015-4054-0","article-title":"Cholestatic liver (dys)function during sepsis and other critical illnesses","volume":"42","author":"M Jenniskens","year":"2016","journal-title":"Intensive Care Med"},{"issue":"03","key":"ref21","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1053\/j.gastro.2009.06.006","article-title":"Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure","volume":"137","author":"WM Lee","year":"2009","journal-title":"Gastroenterology"},{"issue":"02","key":"ref22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1136\/gutjnl-2015-309922","article-title":"Management of acute-on-chronic liver failure: rotational thromboelastometry may reduce substitution of coagulation factors in liver cirrhosis","volume":"65","author":"S Bedreli","year":"2016","journal-title":"Gut"},{"issue":"06","key":"ref23","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.jcrc.2013.08.002","article-title":"Association between renal replacement therapy in critically ill patients with severe acute kidney injury and mortality","volume":"28","author":"SM Bagshaw","year":"2013","journal-title":"J Crit Care"},{"issue":"04","key":"ref24","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cgh.2015.10.007","article-title":"Ability of King\u2019s College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis","volume":"14","author":"MJW McPhail","year":"2016","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2301-8259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T21:06:22Z","timestamp":1742936782000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2301-8259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":24,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2025,3,14]]},"published-print":{"date-parts":[[2025,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2301-8259","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}