{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:10:46Z","timestamp":1790709046004,"version":"4.1.0"},"reference-count":80,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b1-humulene, a sesquiterpene found in essential oils of various plant species, has garnered interest due to its potential therapeutic applications. This scoping review aims to consolidate \u03b1-humulene\u02bcs evidence base, informing clinical translation, and guiding future research directions. A scoping review was conducted of EMBASE, MEDLINE, and PubMed databases up to 14th July 2023. All studies describing original research on \u03b1-humulene extraction, as well as pre-clinical and clinical research, were included for review. Three hundred and forty articles were analysed. \u03b1-humulene yields ranged from negligible to 60.90% across plant species. In vitro experiments demonstrated cytotoxicity against adenocarcinomas (such as colorectal, pulmonary, breast, prostatic, lung, and ovarian), with varying responses in other cell models. Mechanistic insights revealed its involvement in mitochondrial dysfunction, diminished intracellular glutathione levels, and the induction of oxidative stress. In rodent studies, oral administration of \u03b1-humulene at 50\u2009mg\/kg reduced inflammation markers in paw oedema and ovalbumin-induced airway inflammation. Intraperitoneal administration of \u03b1-humulene (50\u200a\u2013\u200a200\u2009mg\/kg) exhibited cannabimimetic properties through cannabinoid 1 and adenosine A2a receptors. \u03b1-humulene also exhibited a multitude of properties with potential scope for therapeutic utilisation. However, there is a paucity of studies that have successfully translated this research into clinical populations with the associated disease. Potential barriers to clinical translation were identified, including yield variability, limited isolation studies, and challenges associated with terpene bioavailability. Consequently, rigorous pharmacokinetic studies and further mechanistic investigations are warranted to effectively uncover the potential of \u03b1-humulene.<\/jats:p>","DOI":"10.1055\/a-2307-8183","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T23:32:57Z","timestamp":1713310377000},"page":"664-674","source":"Crossref","is-referenced-by-count":35,"title":["The Clinical Translation of \u03b1-humulene \u2013 A Scoping Review"],"prefix":"10.1055","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-0501","authenticated-orcid":false,"given":"Nishaanth","family":"Dalavaye","sequence":"additional","affiliation":[{"name":"Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manaswini","family":"Pillai","sequence":"additional","affiliation":[{"name":"Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Erridge","sequence":"additional","affiliation":[{"name":"Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK"},{"name":"Curaleaf Clinic, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael H.","family":"Sodergren","sequence":"additional","affiliation":[{"name":"Medical Cannabis Research Group, Department of Surgery and Cancer, Imperial College London, UK"},{"name":"Curaleaf International, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.phytochem.2009.07.030","article-title":"Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants","volume":"70","author":"J Degenhardt","year":"2009","journal-title":"Phytochemistry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"100217","DOI":"10.1016\/j.fochx.2022.100217","article-title":"Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives","volume":"13","author":"A Masyita","year":"2022","journal-title":"Food Chem X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X20903555","article-title":"Advances in pharmacological activities of terpenoids","volume":"15","author":"W Yang","year":"2020","journal-title":"Nat Prod Commun"},{"key":"ref4","volume-title":"Comprehensive Natural Products II: Chemistry and Biology, Volumes 1 \u2212 10","author":"L Mander","year":"2010"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1039\/jr9420000188","article-title":"32. Cannabis indica. Part X. The essential oil from Egyptian hashish","author":"J L Simonsen","year":"1942","journal-title":"J Chem Soc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41571-022-00672-8","article-title":"Is early-onset cancer an emerging global epidemic? Current evidence and future implications","volume":"19","author":"T Ugai","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"D Furman","year":"2019","journal-title":"Nat Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/femsre\/fuaa001","article-title":"Antibiotic resistance: turning evolutionary principles into clinical reality","volume":"44","author":"D I Andersson","year":"2020","journal-title":"FEMS Microbiol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00253-008-1724-7","article-title":"Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli","volume":"81","author":"H Harada","year":"2009","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.tifs.2021.06.049","article-title":"Pharmacological and toxicological activities of \u03b1-humulene and its isomers: A systematic review","volume":"115","author":"G M Leite","year":"2021","journal-title":"Trends Food Sci Technol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2478\/acph-2019-0003","article-title":"Sesquiterpenes \u03b1-humulene and \u03b2-caryophyllene oxide enhance the efficacy of 5-fluorouracil and oxaliplatin in colon cancer cells","volume":"69","author":"M Ambro\u017e","year":"2019","journal-title":"Acta Pharm"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3390\/molecules22061021","article-title":"The effects of selected sesquiterpenes from Myrica rubra essential oil on the efficacy of doxorubicin in sensitive and resistant cancer cell lines","volume":"22","author":"M Ambro\u017e","year":"2017","journal-title":"Molecules"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15343","DOI":"10.3390\/molecules200815343","article-title":"The influence of sesquiterpenes from Myrica rubra on the antiproliferative and pro-oxidative effects of doxorubicin and its accumulation in cancer cells","volume":"20","author":"M Ambro\u017e","year":"2015","journal-title":"Molecules"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1177\/1934578X1501000744","article-title":"Composition, in vitro cytotoxic, and antimicrobial activities of the flower essential oil of diospyros discolor from Taiwan","volume":"10","author":"Y C Su","year":"2015","journal-title":"Nat Prod Commun"},{"key":"ref15","first-page":"343","article-title":"Cytotoxic activity of alpha-humulene and trans-caryophyllene from Salvia officinalis in animal and human tumor cells","volume":"76","author":"A Hadri","year":"2010","journal-title":"An Real Acad 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Azizan","year":"2017","journal-title":"Molecules"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1139\/cjm-2020-0004","article-title":"Antibacterial and antibiofilm effects of alpha-humulene against Bacteroides fragilis","volume":"66","author":"H I Jang","year":"2020","journal-title":"Can J Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e091","DOI":"10.1590\/1807-3107bor-2022.vol36.0091","article-title":"Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings","volume":"36","author":"T CA Rossato","year":"2022","journal-title":"Braz Oral Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.biopha.2017.04.058","article-title":"Sesquiterpenes evaluation on Schistosoma mansoni: Survival, excretory system and membrane integrity","volume":"90","author":"R N de Oliveira","year":"2017","journal-title":"Biomed 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and improves the anti-inflammatory results in animal models","volume":"112","author":"R T Basting","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/sj.bjp.0707270","article-title":"Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw","volume":"151","author":"R Medeiros","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/j.1476-5381.2009.00177.x","article-title":"Preventive and therapeutic anti-inflammatory properties of the sesquiterpene \u03b1-humulene in experimental airways allergic inflammation","volume":"158","author":"A P Rogerio","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/(SICI)1099-1573(199605)10:3<238::AID-PTR830>3.0.CO;2-S","article-title":"Volatile antiallergic principles from a traditional herbal prescription of kampo medicine","volume":"10","author":"S Tanaka","year":"1996","journal-title":"Phytother Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"110830","DOI":"10.1016\/j.fct.2019.110830","article-title":"\u03b1-Humulene inhibits hepatocellular carcinoma cell proliferation and induces apoptosis through the inhibition of Akt signaling","volume":"134","author":"H Chen","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1055\/s-0035-1545842","article-title":"Antitumor properties of the leaf essential oil of Zornia brasiliensis","volume":"81","author":"E V Costa","year":"2015","journal-title":"Planta Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2006.09.032","article-title":"Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea","volume":"110","author":"G F Passos","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/molecules23020358","article-title":"Antifungal activity of natural volatile organic compounds against litchi downy blight pathogen Peronophythora litchii","volume":"23","author":"M Xing","year":"2018","journal-title":"Molecules"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bjp.2015.05.005","article-title":"Copaifera langsdorffii: Evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves","volume":"25","author":"M Lemos","year":"2015","journal-title":"Rev Bras Farmacogn"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8232","DOI":"10.1038\/s41598-021-87740-8","article-title":"Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity","volume":"11","author":"J E LaVigne","year":"2021","journal-title":"Sci Rep"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jep.2009.10.031","article-title":"Toxicological evaluation of grains of paradise (Aframomum melegueta) [Roscoe] K. Schum","volume":"127","author":"N Ilic","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fmicb.2020.00409","article-title":"Chemical composition and biological activities of the essential oils of Leptospermum petersonii and Eucalyptus gunnii","volume":"11","author":"L Caputo","year":"2020","journal-title":"Front Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.3390\/app10155074","article-title":"Humulus lupulus L. as a natural source of functional biomolecules","volume":"10","author":"G Astray","year":"2020","journal-title":"Appl Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1476-5381.2011.01238.x","article-title":"Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects","volume":"163","author":"E B Russo","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/molecules26030666","article-title":"Essential oils as natural sources of fragrance compounds for cosmetics and cosmeceuticals","volume":"26","author":"J Sharmeen","year":"2021","journal-title":"Molecules"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/cosmetics8040114","article-title":"Essential oils and their individual components in cosmetic products","volume":"8","author":"E Guzm\u00e1n","year":"2021","journal-title":"Cosmetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3390\/cancers12071985","article-title":"Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in cannabis","volume":"12","author":"A M Tomko","year":"2020","journal-title":"Cancers (Basel)"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/carcin\/14.6.1221","article-title":"Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes","volume":"14","author":"J A Elegbede","year":"1993","journal-title":"Carcinogenesis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3390\/antiox10050701","article-title":"Glutathione S-transferases in cancer","volume":"10","author":"R R Singh","year":"2021","journal-title":"Antioxidants"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.51511\/pr.19","article-title":"The potency of alpha-humulene as HER-2 inhibitor by molecular docking","volume":"2","author":"I MH Putra","year":"2022","journal-title":"Pharm Rep"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13045-021-01164-5","article-title":"Combination strategies to maximize the benefits of cancer immunotherapy","volume":"14","author":"S Zhu","year":"2021","journal-title":"J Hematol Oncol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3149362","article-title":"Anticancer properties of essential oils and other natural products","volume":"2018","author":"K Blowman","year":"2018","journal-title":"Evid-Based Complementary Altern Med"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.molcel.2020.05.031","article-title":"Rational cancer treatment combinations: An urgent clinical need","volume":"78","author":"J Boshuizen","year":"2020","journal-title":"Mol Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: Mechanism and clinical study","volume":"5","author":"H Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1124\/pharmrev.120.000046","article-title":"Analgesic potential of terpenes derived from Cannabis sativa","volume":"73","author":"E Liktor-Busa","year":"2021","journal-title":"Pharmacol Rev"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.7861\/clinmed.2021-0039","article-title":"Non-steroidal anti-inflammatory drugs and the gastrointestinal tract","volume":"21","author":"F WD Tai","year":"2021","journal-title":"Clin Med (Northfield Il)"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1038\/s41467-018-05467-z","article-title":"Evaluating intrinsic and non-intrinsic cancer risk factors","volume":"9","author":"S Wu","year":"2018","journal-title":"Nat Commun"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: Signaling pathways and targeted intervention","volume":"6","author":"H Zhao","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"113054","DOI":"10.1016\/j.biopha.2022.113054","article-title":"Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents","volume":"150","author":"S Hashem","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41573-021-00339-6","article-title":"Targeting cancer metabolism in the era of precision oncology","volume":"21","author":"Z E Stine","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13756-019-0533-3","article-title":"Antibiotics versus biofilm: An emerging battleground in microbial communities","volume":"8","author":"D Sharma","year":"2019","journal-title":"Antimicrob Resist Infect Control"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s13756-020-00830-6","article-title":"Biofilm exacerbates antibiotic resistance: Is this a current oversight in antimicrobial stewardship?","volume":"9","author":"P Bowler","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","journal-title":"The Lancet"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41591-022-02160-z","article-title":"The next generation of evidence-based medicine","volume":"29","author":"V Subbiah","year":"2023","journal-title":"Nat Med"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/2231-4040.104712","article-title":"Terpenes: Effect of lipophilicity in enhancing transdermal delivery of alfuzosin hydrochloride","volume":"3","author":"D Prasanthi","year":"2012","journal-title":"J Adv Pharm Technol Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"888079","DOI":"10.3389\/fphar.2022.888079","article-title":"The importance of pharmacokinetics and pharmacodynamics in antimicrobial drug development and their influence on the success of agents developed to combat resistant gram negative pathogens: A review","volume":"13","author":"M E Palmer","year":"2022","journal-title":"Front Pharmacol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000525629","article-title":"Perspectives on challenges in cannabis drug delivery systems: Where are we?","volume":"5","author":"M Palrasu","year":"2022","journal-title":"Med Cannabis Cannabinoids"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","article-title":"Why 90\u200a% of clinical drug development fails and how to improve it?","volume":"12","author":"D Sun","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41231-019-0050-7","article-title":"Lost in translation: The valley of death across preclinical and clinical divide \u2013 identification of problems and overcoming obstacles","volume":"4","author":"A A Seyhan","year":"2019","journal-title":"Transl Med Commun"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e9265","DOI":"10.1002\/ece3.9265","article-title":"The chemical biogeography of a widespread aromatic plant species shows both spatial and temporal variation","volume":"12","author":"K Keefover-Ring","year":"2022","journal-title":"Ecol Evol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: Towards a methodological framework","volume":"8","author":"H Arksey","year":"2005","journal-title":"Int J Soc Res Methodol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping studies: Advancing the methodology","volume":"5","author":"D Levac","year":"2010","journal-title":"Implement 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Schum. seeds (alligator pepper) from Nigeria","volume":"14","author":"E O Ajaiyeoba","year":"1999","journal-title":"Flavour Fragr J"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/1099-1026(200007\/08)15:4<271::AID-FFJ910>3.0.CO;2-E","article-title":"Leaf essential oils of the genus Leptospermum (Myrtaceae) in eastern Australia. Part 6. 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