{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:02:56Z","timestamp":1740168176100,"version":"3.37.3"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Combinations of medications are frequently employed when their effects are\n                    similar. Beyond aiding in the reduction of medication dosages, this approach may\n                    yield additional positive outcomes. Studies have shown that zinc can mitigate\n                    anxiety-related behavior in laboratory animals. This study aimed to investigate\n                    the potential stabilizing effects of zinc chloride and diazepam in Wistar albino\n                    rats.<\/jats:p><jats:p>Five groups, each comprising six animals. Test groups included two combinations\n                    of zinc chloride and diazepam, each with two different doses of diazepam (1 and\n                    2\u2009mg\/kg) and 10\u2009mg\/kg of zinc chloride. Four established anxiety models\u2014the\n                    Elevated Plus Maze (EPM), the hole board, the light and dark box, and the mirror\n                    chamber\u2014were employed to assess the anxiolytic effects. The combination of zinc\n                    chloride and diazepam proved to be more effective than the individual doses of\n                    zinc chloride and diazepam, indicating enhanced anxiolytic effects.<\/jats:p>","DOI":"10.1055\/a-2308-9192","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T01:52:36Z","timestamp":1715392356000},"page":"220-226","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic anxiolytic efficacy exploring the combined effects of\n                    diazepam and zinc chloride in wistar albino rats"],"prefix":"10.1055","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1182-7612","authenticated-orcid":false,"given":"Vishwani V.","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Goa College of Pharmacy, Goa University,\n                    Panjim, Goa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedita Hegde","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Goa College of Pharmacy, Goa University,\n                    Panjim, Goa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Noronha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Goa College of Pharmacy, Goa University,\n                    Panjim, Goa, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0272-7358(85)90010-8","article-title":"The relationship between anxiety and depression","volume":"5","author":"K S Dobson","year":"1985","journal-title":"Clin Psychol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.4103\/0019-5545.69234","article-title":"An overview of Indian research in anxiety 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Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1192\/apt.bp.110.008631","article-title":"Benzodiazepines for anxiety disorders: Maximising the benefits and minimising\n                    the risks","volume":"18","author":"V Starcevic","year":"2012","journal-title":"Adv Psychiatr Treat"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-8223(01)00078-5","article-title":"Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium,\n                    copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and\n                    zinc","volume":"101","author":"P Trumbo","year":"2001","journal-title":"J Am Diet Assoc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"S6349","DOI":"10.4137\/NMI.S6349","article-title":"Decreased Zinc and Increased Copper in Individuals with Anxiety","volume":"4","author":"A J Russo","year":"2011","journal-title":"Nutr Metab Insights"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0192-0561(95)00059-B","article-title":"Reversibility of the thymic involution and of age-related peripheral immune\n                    dysfunctions by zinc supplementation in old mice","volume":"17","author":"E Mocchegiani","year":"1995","journal-title":"Int J Immunopharmacol"},{"key":"ref12","first-page":"588","article-title":"Antidepressant activity of zinc and magnesium in view of the current hypotheses\n                    of antidepressant action","volume":"60","author":"B Szewczyk","year":"2008","journal-title":"Pharmacol Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00394-020-02454-3","article-title":"Neurobiology of zinc and its role in neurogenesis","volume":"60","author":"V Kumar","year":"2021","journal-title":"Eur J Nutr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1177\/1947601912440575","article-title":"Quantitative methods for assessing drug synergism","volume":"2","author":"R J Tallarida","year":"2011","journal-title":"Genes Cancer"},{"key":"ref16","first-page":"12","article-title":"Synergistic Anxiolytic Effect of Curcumin and Zinc on Acute and Chronic Models\n                    of Anxiety in Mice","volume":"14","author":"I Anandan","year":"2020","journal-title":"J Clin Diagnostic Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in\n                    rodents","volume":"2","author":"A A Walf","year":"2007","journal-title":"Nat Protoc"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","article-title":"The mouse light\/dark box test","volume":"463","author":"M Bourin","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0091-3057(90)90215-4","article-title":"Latency to enter a mirrored chamber: a novel behavioral assay for anxiolytic\n                    agents","volume":"35","author":"P L Toubas","year":"1990","journal-title":"Pharmacol Biochem Behav"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1037\/h0026777","article-title":"Mirror-image stimulation","volume":"70","author":"GG J Gallup","year":"1968","journal-title":"Psychol Bull"}],"container-title":["Drug 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