{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:24:53Z","timestamp":1730870693475,"version":"3.28.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney transplantation (KT) is the best option for patients with end-stage renal\n                    disease, but recipients still have legacy bone mineral disease from the\n                    pretransplant period, especially patients with severe secondary\n                    hyperparathyroidism (sHPT). Patients who had severe sHPT and underwent KT were\n                    analyzed retrospectively. Two groups were identified (patients with severe sHPT\n                    who had parathyroidectomy or calcimimetic before KT). Bone mineral density (BMD)\n                    was measured in the first year and last follow-up at the femoral neck, total\n                    hip, and lumbar spine using the dual-energy X-ray absorptiometry (DXA).\n                    Persistent hyperparathyroidism (perHPT) incidence was significantly higher in\n                    the calcimimetic group (75% vs. 40%, p=0.007). In patients with\n                    parathyroidectomy, BMDs were higher at femoral neck (0.818\u00b10.114 vs.\n                    0.744\u00b10.134, p=0.04) and lumbar spine (1.005\u00b10.170 vs. 0.897\u00b10.151, p=0.01) at\n                    the first assessment. The BMD comparison between patients treated with\n                    parathyroidectomy and calcimimetic found a significant difference only in the\n                    femoral neck at second evaluation (0.835\u00b10.118 vs. 0.758\u00b10.129; p=0.03). In\n                    multivariate, linear regression revealed a positive association between the last\n                    BMD of the femoral neck with body mass index (CC: 0.297, 95% CI, 0.002\u20130.017)\n                    and parathyroidectomy (CC: 0.319, 95% CI, 0.021\u20130.156). Parathyroidectomy is\n                    associated with a significantly better femoral neck BMD and a lower incidence of\n                    perHPT in patients with severe sHPT.<\/jats:p>","DOI":"10.1055\/a-2309-2240","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T23:12:04Z","timestamp":1715641924000},"page":"489-497","source":"Crossref","is-referenced-by-count":0,"title":["Pretransplant Parathyroidectomy in Patients with Severe Secondary\n                    Hyperparathyroidism and Long-Term Effectiveness After Kidney\n                    Transplantation"],"prefix":"10.1055","volume":"56","author":[{"given":"Omer Faruk","family":"Akcay","sequence":"additional","affiliation":[{"name":"Nephrology, Gazi University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haci Hasan","family":"Yeter","sequence":"additional","affiliation":[{"name":"Nephrology, Gazi University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Yuksel","sequence":"additional","affiliation":[{"name":"General Surgery, Gazi University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galip","family":"Guz","sequence":"additional","affiliation":[{"name":"Nephrology, Gazi University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2215\/CJN.10390917","article-title":"Parathyroidectomy in the management of secondary hyperparathyroidism","volume":"13","author":"W L Lau","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1492-7535.2003.00021.x","article-title":"Severe cortical and trabecular osteopenia in secondary hyperparathyroidism","volume":"7","author":"D Brancaccio","year":"2003","journal-title":"Hemodial Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e0241201","DOI":"10.1371\/journal.pone.0241201","article-title":"Bone mineral density in Palestinian patients with end-stage renal disease and\n                    the related clinical and biochemical factors: Cross-sectional study","volume":"15","author":"Z Nazzal","year":"2020","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone\n                    disorder (CKD-MBD) guideline update: what's changed and why it matters","volume":"92","author":"M Ketteler","year":"2017","journal-title":"Kidney Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jamcollsurg.2011.12.046","article-title":"Improved long-term survival of dialysis patients after near-total\n                    parathyroidectomy","volume":"214","author":"J Sharma","year":"2012","journal-title":"J Am Coll Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ki.2015.72","article-title":"Parathyroidectomy and survival among Japanese hemodialysis patients with\n                    secondary hyperparathyroidism","volume":"88","author":"H Komaba","year":"2015","journal-title":"Kidney Int"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1093\/ndt\/gfv334","article-title":"The effect of parathyroidectomy on patient survival in secondary\n                    hyperparathyroidism","volume":"30","author":"K M Ivarsson","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1681\/ASN.2007010022","article-title":"Fracture risk after parathyroidectomy among chronic hemodialysis patients","volume":"18","author":"K D Rudser","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1001\/archsurg.136.9.1064","article-title":"Parathyroidectomy can improve bone mineral density in patients with symptomatic\n                    secondary hyperparathyroidism","volume":"136","author":"F F Chou","year":"2001","journal-title":"Arch Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.2215\/CJN.10370915","article-title":"Rates and outcomes of parathyroidectomy for secondary hyperparathyroidism in the\n                    United States","volume":"11","author":"S M Kim","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMoa1205624","article-title":"Effect of cinacalcet on cardiovascular disease in patients undergoing\n                    dialysis","volume":"367","author":"G M Chertow","year":"2012","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3109\/0886022X.2016.1172468","article-title":"Cinacalcet versus standard treatment for chronic kidney disease: a systematic\n                    review and meta-analysis","volume":"38","author":"N Sekercioglu","year":"2016","journal-title":"Ren Fail"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1053\/j.ajkd.2010.07.012","article-title":"Economic analysis of cinacalcet in combination with low-dose vitamin D versus\n                    flexible-dose vitamin D in treating secondary hyperparathyroidism in\n                    hemodialysis patients","volume":"56","author":"T I Shireman","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/01.TP.0000131990.13277.28","article-title":"Early rapid loss followed by long-term consolidation characterizes the\n                    development of lumbar bone mineral density after kidney transplantation","volume":"77","author":"V M Brandenburg","year":"2004","journal-title":"Transplantation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2215\/CJN.11371015","article-title":"Bone disease after kidney transplantation","volume":"11","author":"A Bouquegneau","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1001\/jama.288.23.3014","article-title":"Risk of hip fracture among dialysis and renal transplant recipients","volume":"288","author":"A M Ball","year":"2002","journal-title":"Jama"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/ajt.12652","article-title":"Temporal trends in the incidence, treatment and outcomes of hip fracture after\n                    first kidney transplantation in the United States","volume":"14","author":"S S Nair","year":"2014","journal-title":"Am J Transplant"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1047-2797(01)00226-5","article-title":"Hospitalizations for fractures after renal transplantation in the United\n                    States","volume":"11","author":"K C Abbott","year":"2001","journal-title":"Ann Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"E566","DOI":"10.1111\/j.1399-0012.2011.01515.x","article-title":"Intact parathyroid hormone levels in renal transplant patients with normal\n                    transplant function","volume":"25","author":"I H Bleskestad","year":"2011","journal-title":"Clin Transplant"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1111\/ajt.12425","article-title":"Persistent hyperparathyroidism is a major risk factor for fractures in the five\n                    years after kidney transplantation","volume":"13","author":"P Perrin","year":"2013","journal-title":"Am J Transplant"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1111\/ajt.12913","article-title":"Evaluating the safety and rationale for cinacalcet posttransplant\n                    hyperparathyroidism and hypercalcemia","volume":"14","author":"D W Coyne","year":"2014","journal-title":"Am J Transplant"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ndt\/gfh829","article-title":"Effects of cinacalcet on bone mineral density in patients with secondary\n                    hyperparathyroidism","volume":"20","author":"Y H Lien","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.surg.2016.10.003","article-title":"Parathyroidectomy prior to kidney transplant decreases graft failure","volume":"161","author":"G G Callender","year":"2017","journal-title":"Surgery"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.transproceed.2016.10.011","article-title":"Incidence and risk factors of persistent hyperparathyroidism after kidney\n                    transplantation","volume":"49","author":"K Nakai","year":"2017","journal-title":"Transplant Proc"},{"key":"ref27","first-page":"2096","article-title":"Bone loss after kidney transplantation: a longitudinal study in 115 graft\n                    recipients","volume":"10","author":"W H Grotz","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2215\/CJN.09310819","article-title":"Metabolic disorders with kidney transplant","volume":"15","author":"E Cohen","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00423-020-01953-5","article-title":"Outcomes of parathyroidectomy versus calcimimetics for secondary\n                    hyperparathyroidism and kidney transplantation: a propensity-matched\n                    analysis","volume":"405","author":"E Y Koh","year":"2020","journal-title":"Langenbecks Arch Surg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00198-018-4383-2","article-title":"Changes in bone mineral density after kidney transplantation: 2-year assessment\n                    of a French cohort","volume":"29","author":"N Segaud","year":"2018","journal-title":"Osteoporos Int"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJM199108223250804","article-title":"Rapid loss of vertebral mineral density after renal transplantation","volume":"325","author":"B A Julian","year":"1991","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1016\/j.transproceed.2010.07.106","article-title":"Loss of bone mineral density in renal transplantation recipients","volume":"42","author":"A Unal","year":"2010","journal-title":"Transplant Proc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e13671","DOI":"10.1111\/ctr.13671","article-title":"Addressing bone quality and bone density after renal transplantation: a\n                    prospective evaluation of the evolution of trabecular bone score and bone\n                    mineral density over the first 5 years following renal transplantation in Asian\n                    patients","volume":"33","author":"M Chandran","year":"2019","journal-title":"Clin Transplant"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1681\/ASN.2015060622","article-title":"A randomized study comparing parathyroidectomy with cinacalcet for treating\n                    hypercalcemia in kidney allograft recipients with hyperparathyroidism","volume":"27","author":"J M Cruzado","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.5301\/jn.5000015","article-title":"Determinants of bone mineral density in stable kidney transplant recipients","volume":"25","author":"A K Gupta","year":"2012","journal-title":"J Nephrol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/01.tp.0000230130.50451.78","article-title":"Impact of parathyroid hormone on bone density in long-term renal transplant\n                    patients with good graft function","volume":"82","author":"S Akaberi","year":"2006","journal-title":"Transplantation"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2309-2240.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:16:25Z","timestamp":1730805385000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2309-2240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":34,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2024,7,10]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2309-2240","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published":{"date-parts":[[2024,5,13]]}}}