{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:13Z","timestamp":1740126853215,"version":"3.37.3"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"Excellent Program for Overseas Students of Wuxi City in 2018","award":["23"],"award-info":[{"award-number":["23"]}]},{"name":"Maternal and Child Health Research Project of Jiangsu in China","award":["F202117"],"award-info":[{"award-number":["F202117"]}]},{"name":"Top Talent Support Program for young and middle-aged people in the second term of Wuxi Health Committee","award":["BJ2023054"],"award-info":[{"award-number":["BJ2023054"]}]},{"name":"Wuxi Translational Medicine Research Institute","award":["LCYJ202342"],"award-info":[{"award-number":["LCYJ202342"]}]},{"name":"Top Talent Support Program for young and middle-aged people of Wuxi Health Committee","award":["HB2020038"],"award-info":[{"award-number":["HB2020038"]}]},{"name":"Maternal and Child Health Research Project of Wuxi in China","award":["FYKY201804"],"award-info":[{"award-number":["FYKY201804"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective To investigate the diagnostic value of urine luteinizing hormone\n                    (ULH) after the triptorelin stimulation test detected by immunochemiluminometric\n                    assay (ICMA) in girls with central precocious puberty (CPP).<\/jats:p><jats:p>\n          Methods The girls with precocious puberty were included. The triptorelin\n                    stimulation test at 8:30\u2009a.m. was performed. Two consecutive 12-hour urine\n                    samples were collected after the test, defined as the first 12-hour and second\n                    12-hour urine, respectively. ICMA measured ULH. Urine creatinine (Cr)\n                    concentration was measured. CPP and peripheral precocious puberty (PPP) were\n                    diagnosed by the same pediatric endocrinologist based on clinical symptoms,\n                    signs, and progression of clinical development.<\/jats:p><jats:p>\n          Results A total of 97 cases (CPP n=69; PPP n=28) were included, with 12\n                    cases not meeting the receiver operating characteristic analysis criteria. The\n                    first and second 12-hour ULH\/Cr in the CPP group were higher than those in the\n                    PPP group. When the first 12-hour ULH\/Cr was\u2265287.252 IU\/mol, the sensitivity and\n                    specificity for diagnosing CPP were 87.3% and 90.9%, respectively. When the\n                    second 12-hour ULH\/Cr was\u2265152.769 IU\/mol, the sensitivity and specificity for\n                    diagnosing CPP were 92.1% and 90.9%, respectively. The area under the curve of\n                    the first and second 12-hour ULH\/Cr were 0.933 and 0.954, respectively.<\/jats:p><jats:p>\n          Conclusion The ULH detection method after the triptorelin stimulation test\n                    has clinical significance for diagnosing CPP in girls. When blood sampling\n                    compliance in girls with precocious puberty is poor, the first 12-hour\n                    ULH\/Cr\u2265288 IU\/mol (or second 12-hour\u2265153 IU\/mol) after the triptorelin\n                    stimulation test can serve as a laboratory indicator for diagnosis of CPP.<\/jats:p>","DOI":"10.1055\/a-2316-4772","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T23:12:52Z","timestamp":1714432372000},"page":"389-395","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of Stimulated Urine Luteinizing Hormone After\n                    Triptorelin Stimulation Test in Girls with Central Precocious\n                    Puberty"],"prefix":"10.1055","volume":"132","author":[{"given":"Ruofan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-0815","authenticated-orcid":false,"given":"Zhuangjian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beilei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi Sixth People's Hospital, Binhu District Mashan Street\n                    Community Health Centre, Wuxi 214091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panwang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Clinical laboratory, Affiliated Hospital of Jiangnan\n                    University, Wuxi, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-sheng","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-5259","authenticated-orcid":false,"given":"Yaping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Affiliated Hospital of Jiangnan University,\n                    Wuxi, Jiangsu, China"},{"name":"Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000501336","article-title":"Use of gonadotropin-releasing hormone analogs in children: Update by an\n                    international consortium","volume":"91","author":"K Bangalore Krishna","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"ref2","first-page":"30","article-title":"Use of leuprolide acetate response patterns in the early diagnosis of pubertal\n                    disorders: comparison with the gonadotropin-releasing hormone test","volume":"78","author":"L Ib\u00e1\u00f1ez","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4103\/2230-8210.95682","article-title":"Evaluation of GnRH analogue testing in diagnosis and management of children with\n                    pubertal disorders","volume":"16","author":"H K Prasad","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4274\/jcrpe.v3i1.03","article-title":"GnRH stimulation test in precocious puberty: Single sample is adequate for\n                    diagnosis and dose adjustment","volume":"3","author":"N Kandemir","year":"2011","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2265.2012.04517.x","article-title":"High diagnostic accuracy of subcutaneous triptorelin test compared with GnRH\n                    test for diagnosing central precocious puberty in girls","volume":"78","author":"A V Freire","year":"2013","journal-title":"Clin Endocrinol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin-releasing hormone-stimulated gonadotropins\n                    by immunochemiluminometric and immunofluorometric assays in normal children","volume":"92","author":"E A Resende","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0022-3476(77)81243-2","article-title":"Timed urinary gonadotropin measurements in normal infants, children, and adults,\n                    and in patients with disorders of sexual maturation","volume":"90","author":"H E Kulin","year":"1977","journal-title":"J Pediatr"},{"key":"ref8","first-page":"2963","article-title":"Increase in first morning voided urinary luteinizing hormone levels precedes the\n                    physical onset of puberty","volume":"81","author":"A Demir","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1159\/000179305","article-title":"Radioimmunoassays of unextracted gonadotrophins in timed fractions of 24-hour\n                    urine: Morning increase of gonadotrophin excretion, a circadian pattern in\n                    relation to puberty","volume":"13","author":"J P Bourguignon","year":"1980","journal-title":"Horm Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.6065\/apem.2040208.104","article-title":"Single random measurement of urinary gonadotropin concentration for screening\n                    and monitoring girls with central precocious puberty","volume":"26","author":"S Y Lee","year":"2021","journal-title":"Ann Pediatr Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1515\/cclm-2022-0296","article-title":"First morning voided urinary gonadotropins in children: Verification of method\n                    performance and establishment of reference intervals","volume":"60","author":"Y Yao","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1530\/EJE-14-0010","article-title":"The diagnostic value of first-voided urinary LH compared with GNRH-stimulated\n                    gonadotropins in differentiating slowly progressive from rapidly progressive\n                    precocious puberty in girls","volume":"170","author":"A Zung","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"ref13","first-page":"47","article-title":"Nocturnal urinary gonadotropin in diagnosis of precocious puberty in girls","volume":"16","author":"T Zhang","year":"2012","journal-title":"J Clin Med Pract"},{"key":"ref14","first-page":"1701","article-title":"The dynamic trends of urinary LH and FSH assayed by ICMA during triptorelin\n                    stimulation tests in girls-a pilot study","volume":"64","author":"Y Ma","year":"2018","journal-title":"Clin Lab"},{"key":"ref15","first-page":"877","article-title":"Effects of storage conditions on urinary LH and FSH measurement using\n                    immunochemiluminometric assay","volume":"64","author":"Y Ma","year":"2018","journal-title":"Clin Lab"},{"volume-title":"Tanner stages","year":"2022","author":"M Emmanuel","key":"ref16"},{"key":"ref17","first-page":"599","article-title":"Value of urinary gonadotropin during gonadotropin - releasing hormone analog\n                    stimulation testing in monitoring gonadotropin-releasing hormone analog therapy\n                    for children","volume":"27","author":"Y Ma","year":"2012","journal-title":"J Appl Clin Pediatr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1687-9856-2012-10","article-title":"Urinary gonadotrophins: A useful non-invasive marker of activation of the\n                    hypothalamic pituitary-gonadal axis","volume":"2012","author":"J D McNeilly","year":"2012","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00008480-200008000-00020","article-title":"Management of central isosexual precocity: Diagnosis, treatment, outcome","volume":"12","author":"M C Lebrethon","year":"2000","journal-title":"Curr Opin Pediatr"},{"key":"ref20","first-page":"493","article-title":"Body mass index growth curves for Chinese children and adolescents aged 0 to 18\n                    years","volume":"47","author":"H Li","year":"2009","journal-title":"Chin J Pediatr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/2359-3997000000144","article-title":"Central precocious puberty: Revisiting the diagnosis and therapeutic\n                    management","volume":"60","author":"V N Brito","year":"2016","journal-title":"Arch Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1210\/jc.2017-01192","article-title":"Nocturnal urinary excretion of FSH and LH in children and adolescents with\n                    normal and early puberty","volume":"102","author":"N Kolby","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"ref23","first-page":"3539","article-title":"Diagnostic value of fluorometric assays in the evaluation of precocious\n                    puberty","volume":"84","author":"V N Brito","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1210\/jc.2013-3292","article-title":"The response to gonadotropin releasing hormone (GnRH) stimulation test does not\n                    predict the progression to true precocious puberty in girls with onset of\n                    premature thelarche in the first three years of life","volume":"99","author":"C Bizzarri","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1007\/s12020-021-02947-z","article-title":"Triptorelin stimulated luteinizing hormone concentrations for diagnosing central\n                    precocious puberty: Study of diagnostic accuracy","volume":"75","author":"R Vukovic","year":"2022","journal-title":"Endocrine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/00365513.2022.2148120","article-title":"A single blood sample for stimulated LH assayed by ICMA is useful for monitoring\n                    the treatment efficacy of triptorelin depot in girls","volume":"82","author":"Y Zhou","year":"2022","journal-title":"Scand J Clin Lab Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2265.2010.03796.x","article-title":"Leuprolide stimulation testing for the evaluation of early female sexual\n                    maturation","volume":"73","author":"A Sathasivam","year":"2010","journal-title":"Clin Endocrinol"},{"key":"ref28","first-page":"1550","article-title":"Value of urinary gonadotropin determinations during gonadotropin-releasing\n                    hormone analog stimulation testing in children","volume":"25","author":"X Wang","year":"2010","journal-title":"J Appl Clin Pediatr"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2316-4772.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T10:31:11Z","timestamp":1730802671000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2316-4772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":28,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2024,7,16]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2316-4772","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published-other":{"date-parts":[[2024,4,29]]},"published":{"date-parts":[[2024,4,29]]}}}