{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:42:38Z","timestamp":1794368558950,"version":"4.9.0"},"reference-count":69,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n            Objective\u2003To examine the association of adverse outcomes among parturients with large for gestational age (LGA; birth weight \u2265 90th) newborns, stratified by diabetes status. Additionally, we described the temporal trends of adverse outcomes among LGA neonates.<\/jats:p><jats:p>\n            Study Design\u2003This retrospective cohort study used the U.S. Vital Statistics dataset between 2014 and 2020. The inclusion criteria were singleton, nonanomalous LGA live births who labored and delivered at 24 to 41 weeks with known diabetes status. The coprimary outcomes were composite neonatal adverse outcomes of the following: Apgar score\u2009&lt;\u20095 at 5\u2009minutes, assisted ventilation\u2009&gt;\u20096\u2009hours, seizure, or neonatal or infant mortality, and maternal adverse outcomes of the following: maternal transfusion, ruptured uterus, unplanned hysterectomy, admission to intensive care unit, or unplanned procedure. Multivariable Poisson regression models were used to estimate adjusted relative risks (aRR) and 95% confidence intervals (CI). Average annual percent change (AAPC) was calculated to assess changes in rates of LGA and morbidity over time.<\/jats:p><jats:p>\n            Results\u2003Of 27 million births in 7 years, 1,843,467 (6.8%) met the inclusion criteria. While 1,656,888 (89.9%) did not have diabetes, 186,579 (10.1%) were with diabetes. Composite neonatal adverse outcomes (aRR\u2009=\u20091.48, 95% CI\u2009=\u20091.43, 1.52) and composite maternal adverse outcomes (aRR\u2009=\u20091.37, 95% CI\u2009=\u20091.36, 1.38) were significantly higher among individuals with diabetes, compared with those without diabetes. From 2014 to 2020, the LGA rate was stable among people without diabetes. However, there was a downward trend of LGA in people with diabetes (AAPC\u2009=\u2009\u2212\u20092.4, 95% CI\u2009=\u2009\u2212\u20093.5, \u22121.4).<\/jats:p><jats:p>\n            Conclusion\u2003In pregnancies with LGA newborns, composite neonatal and maternal morbidities were higher in those with diabetes, compared with those without diabetes.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2316-9007","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T22:55:46Z","timestamp":1714517746000},"page":"014-024","source":"Crossref","is-referenced-by-count":5,"title":["Large for Gestational Age and Adverse Outcomes: Stratified By Diabetes Status"],"prefix":"10.1055","volume":"42","author":[{"given":"Sarah A.","family":"Nazeer","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joycelyn Ashby","family":"Cornthwaite","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneet P.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Delaware Center of Maternal-Fetal Medicine, Newark, Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha","family":"Sibai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, University of Texas Health Sciences Center at Houston, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2715-2755","authenticated-orcid":false,"given":"Stephen","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal F.","family":"Bartal","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas"},{"name":"Department of Obstetrics and Gynecology, Sheba Medical Center, Tel 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