{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:30:33Z","timestamp":1764228633397,"version":"3.46.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Gegenstand und Ziel St\u00f6rungen des S\u00e4uren-Basen-Status (SBS) in\n                    Milchviehbest\u00e4nden lassen sich durch die Bestimmung der\n                    Netto-S\u00e4uren-Basen-Ausscheidung (NSBA) im Harn diagnostizieren. Modifikationen\n                    dieser Methode sind die differenzierte NSBA (dNSBA) mit Bestimmung des\n                    harnkonzentrationsunabh\u00e4ngigen Basen-S\u00e4uren-Quotienten (BSQ) und der\n                    vereinfachte NSBA-Siebtest. Ziel dieser Studie war es, diese Methoden sowohl\n                    untereinander als auch als Pooluntersuchung in ihrer Beurteilung des SBS von\n                    Kuhgruppen zu vergleichen und daraus Empfehlungen f\u00fcr die Praxis abzuleiten.<\/jats:p>\n                  <jats:p>Tiere, Material und Methoden Aus Harnproben von 855 Deutsch-Holstein-K\u00fchen\n                    in 127 Kuhgruppen verschiedener Laktationsstadien wurden die Konzentrationen der\n                    NSBA, der dNSBA und der Siebtest-NSBA gemessen sowie der BSQ berechnet; dNSBA\n                    und BSQ wurden einzeln und als Pool einer Gruppe bestimmt. In gemischten\n                    linearen Modellen wurden f\u00fcr diese beiden Parameter die Beziehung zwischen dem\n                    Mittelwert der Einzeltierwerte und dem Ergebnis der Poolprobenuntersuchung einer\n                    Gruppe untersucht. Zudem wurden alle Gruppen anhand ihrer Einzeltierergebnisse\n                    der jeweiligen Methoden, den daraus gebildeten Mittelwerten und des Messwertes\n                    im Pool hinsichtlich azidotischer oder alkalotischer Belastung beurteilt und\n                    unter Nutzung des Einzeltier-BSQ als Referenz die Sensitivit\u00e4t und Spezifit\u00e4t\n                    der verschiedenen Methoden berechnet.<\/jats:p>\n                  <jats:p>Ergebnisse Die Mittelwerte der Einzelmessungen von dNSBA und BSQ\n                    unterschieden sich insbesondere in den Grenzbereichen vom Messwert in der\n                    Poolprobe. In der Gruppenbeurteilung zeigte die NSBA die beste kombinierte\n                    Sensitivit\u00e4t und Spezifit\u00e4t zur Erkennung von St\u00f6rungen des SBS. Die\n                    dNSBA-Pooluntersuchung zeigte eine gute Spezifit\u00e4t hinsichtlich Azidose und\n                    Alkalose, w\u00e4hrend der NSBA-Siebtest auf Einzeltierbasis und die BSQ-Bestimmung\n                    im Pool eine gute Sensitivit\u00e4t hinsichtlich Azidose aufwiesen.<\/jats:p>\n                  <jats:p>Schlussfolgerungen und klinische Relevanz Es zeigte sich, dass die NSBA\n                    auf Einzeltierbasis gut zur Beurteilung des SBS von Kuhgruppen geeignet ist und\n                    daher f\u00fcr den Praxiseinsatz empfohlen werden kann. Die Bestimmung der dNSBA\n                    sowie des BSQ als Pooluntersuchung ist nicht ausreichend zur Erkennung\n                    alkalotisch belasteter Kuhgruppen, kann aber zur Best\u00e4tigung einer vorliegenden\n                    azidotischen Last beitragen.<\/jats:p>","DOI":"10.1055\/a-2317-1359","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T18:40:54Z","timestamp":1719427254000},"page":"125-136","source":"Crossref","is-referenced-by-count":0,"title":["Methodenvergleich zur \u00dcberwachung des S\u00e4uren-Basen-Status in\n                    Milchviehherden"],"prefix":"10.1055","volume":"52","author":[{"given":"Tanja","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Th\u00fcringer Tierseuchenkasse, Ad\u00f6R, Tiergesundheitsdienst,\n                    Jena"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Reinhold","sequence":"additional","affiliation":[{"name":"Friedrich-Loeffler-Institut, Institut f\u00fcr molekulare Pathogenese,\n                    Jena"},{"name":"Institut f\u00fcr Veterin\u00e4r-Physiologie, Freie Universit\u00e4t\n                    Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Donat","sequence":"additional","affiliation":[{"name":"Th\u00fcringer Tierseuchenkasse, Ad\u00f6R, Tiergesundheitsdienst,\n                    Jena"},{"name":"Tierklinik f\u00fcr Reproduktionsmedizin und Neugeborenenkunde,\n                    Justus-Liebig-Universit\u00e4t Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref2","first-page":"9","article-title":"Stoffwechselkrankheiten bei Wiederk\u00e4uern in Massentierhaltungen \u2013 Die St\u00f6rungen\n                    des S\u00e4ure-Basen-Gleichgewichtes","volume":"60","author":"B Juh\u00e1sz","year":"1979","journal-title":"Prakt Tierarzt"},{"key":"ref3","first-page":"466","article-title":"Diagnostik f\u00fctterungsbedingter metabolischer Azidosen und Alkalosen beim\n                    Rind","volume":"34","author":"G Lachmann","year":"1985","journal-title":"Wiss Z Karl-Marx-Univ Leipzig, Math-Naturwiss R"},{"key":"ref4","first-page":"49","article-title":"Diagnostik und Therapie chronischer St\u00f6rungen des S\u00e4ure-Basen-Haushaltes (SBH)\n                    bei Rindern","volume":"75","author":"M F\u00fcrll","year":"1993","journal-title":"Prakt Tierarzt"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.anifeedsci.2005.08.004","article-title":"Understanding and preventing subacute ruminal acidosis in dairy herds: A\n                    review","volume":"126","author":"K M Krause","year":"2006","journal-title":"Anim Feed Sci Technol"},{"volume-title":"Der Einfluss der H\u00e4cksell\u00e4nge von Maissilage auf den S\u00e4uren-Basen-Haushalt von\n                    Milchk\u00fchen [Diss med vet]","year":"2010","author":"S Bandilla","key":"ref6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.17169\/refubium-30786","author":"S Woida","year":"2021","journal-title":"Experimentelle Untersuchungen zum Effekt von Rationen mit einem\n                    unterschiedlichen Gehalt an strukturwirksamer Rohfaser und des Einsatzes von\n                    Natriumhydrogencarbonat auf den S\u00e4uren-Basen-Haushalt von Milchk\u00fchen [Diss med\n                    vet]: FU Berlin"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.2527\/1998.761275x","article-title":"Acidosis in cattle: a review","volume":"76","author":"F N Owens","year":"1998","journal-title":"J Anim Sci"},{"key":"ref9","first-page":"44","article-title":"Zur Problematik der metabolischen Azidose des Wiederk\u00e4uers","volume":"34","author":"G Lachmann","year":"1979","journal-title":"Mh Vet Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1136\/inpract.28.9.510","article-title":"Modern techniques for monitoring high-producing dairy cows 1","volume":"28","author":"N Cook","year":"2006","journal-title":"Principles of herd-level diagnoses. 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