{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T18:10:21Z","timestamp":1730916621729,"version":"3.28.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Immunthrombozytopenie (ITP) entsteht durch Autoantik\u00f6rper-Bildung gegen Oberfl\u00e4chenantigene der Blutpl\u00e4ttchen. Die Erkrankung tritt als prim\u00e4re ITP ohne eindeutigen Ausl\u00f6ser oder als sekund\u00e4re ITP (Medikamente, andere Krankheitsbilder) auf. Die Autoantik\u00f6rper-Bildung f\u00fchrt zu einem Verlust von Thrombozyten in Milz oder Leber und reduziert daneben auch die Bildung von Thrombozyten. Die Synthese von Thrombopoetin ist bei ITP-Patienten \u2013 im Gegensatz anderen Bildungsst\u00f6rungen der Thrombozyten \u2013 reduziert. Die ITP ist eine Ausschlussdiagnose, beweisende Laboruntersuchung liegen nicht vor. Nur in 50% der F\u00e4lle lassen sich Glykoprotein-spezifische Antik\u00f6rper nachweisen. Von besonderer Bedeutung ist der Ausschluss der EDTA-induzierten Pseudothrombozytopenie. Andere Ursachen der Thrombozytopenie sollten durch (Medikamenten-)Anamnese, k\u00f6rperliche Untersuchung und gegebenenfalls Knochenmarkpunktion ausgeschlossen werden.<\/jats:p>","DOI":"10.1055\/a-2317-3073","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T22:50:13Z","timestamp":1719874213000},"page":"832-838","source":"Crossref","is-referenced-by-count":0,"title":["Pathophysiologie und Diagnostik der Immunthrombozytopenie"],"prefix":"10.1055","volume":"149","author":[{"given":"Aristoteles","family":"Giagounidis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Onkologie, H\u00e4matologie und Palliativmedizin, Marien Hospital D\u00fcsseldorf, D\u00fcsseldorf, GERMANY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1182\/blood-2008-07-162503","article-title":"Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group","volume":"113","author":"F Rodeghiero","year":"2009","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1056\/NEJMcp1810479","article-title":"Immune Thrombocytopenia","volume":"381","author":"N Cooper","year":"2019","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1080\/17474086.2021.1995347","article-title":"Immune thrombocytopenia","volume":"14","author":"J Bussel","year":"2021","journal-title":"Exp Rev Hematol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1182\/blood.V70.4.1040.1040","article-title":"Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP","volume":"70","author":"R McMillan","year":"1987","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1365-2141.1991.tb04530.x","article-title":"Autoantibodies against platelet glycoprotein Ib\/IX: a frequent finding in autoimmune thrombocytopenic purpura","volume":"79","author":"V Kiefel","year":"1991","journal-title":"Br J Heamatol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e574","DOI":"10.1097\/hs9.0000000000000574","article-title":"Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments","volume":"5","author":"S Audia","year":"2021","journal-title":"HemaSphere"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1182\/blood.V83.4.1024.1024","article-title":"Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura","volume":"83","author":"R He","year":"1994","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1182\/blood-2003-08-2672","article-title":"Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP","volume":"103","author":"R McMillan","year":"2004","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1182\/blood.V65.3.584.584","article-title":"Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia","volume":"65","author":"D Stoll","year":"1985","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1182\/blood.V67.1.86.86","article-title":"Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111In-labeled platelets and homologous 51Cr-labeled platelets differ","volume":"67","author":"P Heyns Adu","year":"1986","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1172\/JCI113060","article-title":"Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance","volume":"80","author":"PJ Ballem","year":"1987","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1182\/blood-2002-05-1475","article-title":"Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro","volume":"102","author":"M Chang","year":"2003","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3324\/haematol.2014.115634","article-title":"Immune thrombocytopenia: antiplatelet autoantibodies inhibit proplatelet formation by megakaryocytes and impair platelet production in vitro","volume":"100","author":"M Iraqi","year":"2015","journal-title":"Haematologica"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1365-2141.2009.07717.x","article-title":"Pathogenesis of chronic immune thrombocytopenia: increased platelet destruction and\/or decreased platelet production","volume":"146","author":"D Nugent","year":"2009","journal-title":"Br J Haematol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"K Honda","year":"2016","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.thromres.2020.03.012","article-title":"Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia","volume":"190","author":"C Liu","year":"2020","journal-title":"Thromb Res"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.7150\/ijbs.33779","article-title":"Disrupted balance of CD4(+) T-cell subsets in bone marrow of patients with primary immune thrombocytopenia","volume":"15","author":"Q Wang","year":"2019","journal-title":"Int J Biol Sci"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/ajh.20951","article-title":"The role of autoantibody-producing plasma cells in immune thrombocytopenic purpura refractory to rituximab","volume":"82","author":"M Kuwana","year":"2007","journal-title":"Am J Hematol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3318","DOI":"10.1182\/blood-2012-05-432575","article-title":"Defective regulatory B-cell compartment in patients with immune thrombocytopenia","volume":"120","author":"X Li","year":"2012","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fped.2016.00102","article-title":"The Centenary of Immune Thrombocytopenia \u2013 Part 1: Revising Nomenclature and Pathogenesis","volume":"4","author":"R Consolini","year":"2016","journal-title":"Front Pediatr"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12691","article-title":"Sialic acid and platelet count regulation: Implications in immune thrombocytopenia","volume":"6","author":"MM Lee-Sundlov","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1182\/bloodadvances.2022007751","article-title":"The interplay between GPIb\/IX antibodies, platelet hepatic sequestration, and TPO levels in patients with chronic ITP","volume":"7","author":"SN Amini","year":"2023","journal-title":"Blood advances"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/jth.12524","article-title":"Association of autoantibody specificity and response to intravenous immunoglobulin G therapy in immune thrombocytopenia: a multicenter cohort study","volume":"12","author":"J Peng","year":"2014","journal-title":"J Thromb Haemost"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"7737","DOI":"10.1038\/ncomms8737","article-title":"Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia","volume":"6","author":"J Li","year":"2015","journal-title":"Nat Commun"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3324\/haematol.2021.279751","article-title":"Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia","volume":"107","author":"SS Zheng","year":"2022","journal-title":"Haematologica"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3109\/09537104.2014.948838","article-title":"Successful treatment with oseltamivir phosphate in a patient with chronic immune thrombocytopenia positive for anti-GPIb\/IX autoantibody","volume":"26","author":"L Shao","year":"2015","journal-title":"Platelets"},{"key":"ref29","first-page":"293","article-title":"Hautblutungen durch Stauung hervorgerufen als diagnostisches Hilfsmittel beim Scharlach","volume":"58","author":"C Leede","year":"1911","journal-title":"M\u00fcnchen med Wchnschr"},{"key":"ref30","first-page":"2297","article-title":"Photographien von Scharlachkranken mit multiplen Hautblutungen","volume":"35","author":"T Rumpel","year":"1909","journal-title":"Dtsch Med Wochenschr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1182\/blood.2020004858","article-title":"Identification of occult cerebral microbleeds in adults with immune thrombocytopenia","volume":"136","author":"N Cooper","year":"2020","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1182\/blood-2014-05-578336","article-title":"Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France","volume":"124","author":"G Moulis","year":"2014","journal-title":"Blood"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1001\/archinte.160.11.1630","article-title":"The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts","volume":"160","author":"YC Cohen","year":"2000","journal-title":"Arch Int Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1365-2141.2010.08418.x","article-title":"Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study","volume":"152","author":"MT Severinsen","year":"2011","journal-title":"Br J Haematol"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1111\/bjh.13385","article-title":"Hill QA, Newland AC. Fatigue in immune thrombocytopenia","volume":"170","year":"2015","journal-title":"Br J Haematol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2147\/jbm.s189176","article-title":"Post-Transfusion Purpura: Current Perspectives","volume":"10","author":"J Hawkins","year":"2019","journal-title":"J Blood Med"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1056\/NEJMoa1802897","article-title":"Platelet Counts during Pregnancy","volume":"379","author":"JA Reese","year":"2018","journal-title":"N Engl J Med"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1182\/asheducation-2018.1.561","article-title":"How do we diagnose immune thrombocytopenia in 2018?","volume":"2018","author":"JG Kelton","year":"2018","journal-title":"Hematology"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1515\/labmed-2023-0032","article-title":"EDTA-associated pseudothrombocytopenia: definition and real-world occurrence","volume":"47","author":"R Markewitz","year":"2023","journal-title":"Lab Med"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1055\/s-0029-1220327","article-title":"MYH9-related platelet disorders","volume":"35","author":"K Althaus","year":"2009","journal-title":"Semin Thromb Hemost"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/jth.14419","article-title":"The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta-analysis of a diagnostic test","volume":"17","author":"JR Vrbensky","year":"2019","journal-title":"J Thromb Haemost"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1182\/bloodadvances.2019000868","article-title":"A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia","volume":"4","author":"H Al-Samkari","year":"2020","journal-title":"Blood advances"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2317-3073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:50:45Z","timestamp":1730818245000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2317-3073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":40,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2024,7,1]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2317-3073","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"type":"print","value":"0012-0472"},{"type":"electronic","value":"1439-4413"}],"subject":[],"published":{"date-parts":[[2024,7]]}}}