{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:35:59Z","timestamp":1791387359713,"version":"4.3.3"},"reference-count":76,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Management of Cushing\u2019s syndrome (CS) can be particularly challenging in older\n                    patients, compared with younger individuals, due to the lack of several clinical\n                    features associated with cortisol excess along with a greater burden of\n                    associated comorbidities. Moreover, the interpretation of diagnostic tests could\n                    be influenced by age-related physiological changes in cortisol secretion. While\n                    mortality is higher and quality of life is more impaired in the elderly with CS\n                    as compared with the younger, there is currently no agreement on the most\n                    effective therapeutic options in aged individuals, and safety data concerning\n                    medical treatment are scanty. In this review, we summarize the current knowledge\n                    about age-related differences in CS etiology, clinical presentation, treatment,\n                    and outcomes and describe the potential underlying mechanisms.<\/jats:p>","DOI":"10.1055\/a-2317-8821","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:24:51Z","timestamp":1714713891000},"page":"705-711","source":"Crossref","is-referenced-by-count":8,"title":["Cushing's Syndrome in the Elderly"],"prefix":"10.1055","volume":"132","author":[{"given":"Aleksandra","family":"Zdrojowy-We\u0142na","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw\n                    Medical University, Wroclaw, Poland"},{"name":"Endocrinology Department, Wroclaw University Hospital, Wroclaw,\n                    Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Valassi","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Germans Trias i Pujol Hospital\n                    and Research Institute, Badalona, Spain"},{"name":"School of Medicine, Universitat Internacional de Catalunya (UIC),\n                    Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e13114","DOI":"10.1111\/jne.13114","article-title":"Clinical presentation and etiology of Cushing\u2019s syndrome: Data from ERCUSYN","volume":"34","author":"E Valassi","year":"2022","journal-title":"J Neuroendocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/cen.14014","article-title":"The incidence of endogenous Cushing\u2019s syndrome in the modern era","volume":"91","author":"S Wengander","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref3","first-page":"105","article-title":"Time to diagnosis in Cushing\u2019s syndrome: A meta-analysis based on 5367\n                    patients","author":"G Rubinstein","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3389\/fendo.2019.00766","article-title":"Toward a diagnostic score in Cushing\u2019s syndrome","volume":"10","author":"L T Braun","year":"2019","journal-title":"Front Endocrinol"},{"key":"ref5","volume-title":"Definition of an older person. 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