{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:23:00Z","timestamp":1783178580318,"version":"3.54.6"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal hyperthyroidism is a rare prenatal disease and can be life-threatening. The diagnosis is based on ultrasound in mothers with a history of Basedow\u2013Graves' disease and elevation of thyrotropin receptor antibodies (TRAbs) levels. The treatment consists of antithyroid drugs. We present a mother with Basedow\u2013Graves' disease, treated with radioactive iodine 16 years ago. She had an unplanned pregnancy at the age of 29 years, and an elevation of TRAbs (21 U\/L) was found at the sixth week of pregnancy. At 22 weeks of gestation, fetal ultrasound displayed tachycardia, goiter, exophthalmos, and suspicion of craniosynostosis, hence methimazole was started. Concomitantly, suppressed maternal thyroid-stimulating hormone (TSH) was found. Her daughter was born at 33\u2009+\u20096 weeks showing clinical and laboratory findings of hyperthyroidism. Consequently, treatment with methimazole was prescribed. Normal thyroid function was documented in the mother after giving birth. Clear explanation has not been found for the alteration of maternal TSH during pregnancy.<\/jats:p>","DOI":"10.1055\/a-2317-9431","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T05:23:21Z","timestamp":1714713801000},"page":"e176-e183","source":"Crossref","is-referenced-by-count":5,"title":["Fetal Hyperthyroidism Secondary to Maternal Basedow\u2013Graves' Disease"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-6923","authenticated-orcid":false,"given":"Julio","family":"Soto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad de Concepcion, Concepcion, Chile"},{"name":"Division of Pediatric Endocrinology, Pediatrics Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunio","family":"Weissglas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Universidad de Concepcion, Concepcion, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-7172","authenticated-orcid":false,"given":"Gustav","family":"von Plessing-Pierry","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Universidad de Concepcion, Concepcion, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paz","family":"del Solar","sequence":"additional","affiliation":[{"name":"Department of Clinical and Preclinical Sciences, School of Medicine, Universidad Catolica de la Santisima Concepcion, Concepcion, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Pe\u00f1a-Villa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Universidad de Concepcion, Concepcion, Chile"},{"name":"Division of Endocrinology, Internal Medicine Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximena","family":"Flores","sequence":"additional","affiliation":[{"name":"Division of Obstetric and Gynecologic Ultrasound, Obstetrics and Gynecology Service, Hospital Las Higueras, Talcahuano, Chile"},{"name":"Department of Obstetrics and Ginecology, School of Medicine, Universidad de Concepcion, Concepcion, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Arancibia","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Pediatrics Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Campos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Pediatrics Service, Hospital Las Higueras, Talcahuano, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1542\/neo.21-1-e30","article-title":"Thyroid function during the fetal and neonatal periods","volume":"21","author":"L Eng","year":"2020","journal-title":"Neoreviews"},{"issue":"05","key":"ref2","first-page":"235","article-title":"Congenital hyperthyroidism: the fetus as a patient","volume":"65","author":"M Polak","year":"2006","journal-title":"Horm Res"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.beem.2018.03.014","article-title":"Diagnosis and management of hyperthyroidism from prenatal life to adolescence","volume":"32","author":"J L\u00e9ger","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000453065","article-title":"Management of fetal and neonatal Graves' disease","volume":"87","author":"J L\u00e9ger","year":"2017","journal-title":"Horm Res Paediatr"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1210\/jc.2004-2555","article-title":"Management of Graves' disease during pregnancy: the key role of fetal thyroid gland monitoring","volume":"90","author":"D Luton","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"02","key":"ref6","first-page":"35","article-title":"Hipertiroidismo en el embarazo. 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