{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:14:24Z","timestamp":1788383664623,"version":"build-2803163510"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim This study aimed to demonstrate the role of Epstein-Barr Virus (EBV)\n                    in papillary thyroid carcinomas (PTC) developing on the background of\n                    Hashimoto\u02bcs thyroiditis (HT).<\/jats:p><jats:p>\n          Methods The presence of EBV in tumoral tissue, lymphocytes, and\n                    peritumoral normal thyroid tissue was investigated using the in situ\n                    hybridization method in paraffin blocks. The subtypes of PTC, tumor diameter,\n                    TNM stage, multifocality, invasion of thyroid capsule, perineural invasion, and\n                    muscular tissue invasion were identified and compared according to EBV\n                    involvement.<\/jats:p><jats:p>\n          Results Eighty-one patients with HT diagnosis, with 93.8% (n=76) female\n                    and 6.2% (n=5) male, were included in the study. Papillary microcarcinoma was\n                    the pathological diagnosis in 24.2% (n=15) of the cases. EBV was identified in\n                    58.06% (n=36) of the tumor cells nuclei, 58.06% (n=36) in the tumor cell\n                    cytoplasm, 16.12% (n=10) in tumor infiltrative lymphocytes, and 53.2% (n=33) in\n                    normal parenchymal follicle epithelial cells (NPFEC). In the T2 stage, the rate\n                    of EBV nuclear positivity in patients was significantly higher (p=0.034). The\n                    classic variant of papillary carcinoma was accompanied by a significantly higher\n                    rate of EBV-negative NPFEC (67.6%, p=0.049). In multifocal tumors, EBV\n                    positivity was found to be significantly higher in lymphocytes in the\n                    surrounding tissues (58.3%, p=0.034).<\/jats:p><jats:p>\n          Conclusion A significant increase in EBV positivity in the surrounding\n                    tissue lymphocytes was observed in multifocal PTC developing on a background of\n                    HT. This suggests a possible association between HT and EBV.<\/jats:p>","DOI":"10.1055\/a-2322-7355","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T22:58:04Z","timestamp":1720047484000},"page":"469-475","source":"Crossref","is-referenced-by-count":4,"title":["Demonstration of Epstein-Barr Virus by In Situ Hybridization in\n                    Papillary Thyroid Carcinomas Developing on Background of Hashimoto\u2019s\n                    Thyroiditis"],"prefix":"10.1055","volume":"132","author":[{"given":"Serap","family":"Karaarslan","sequence":"additional","affiliation":[{"name":"Department of Pathology, \u0130zmir T\u0131naztepe University, \u0130zmir,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin","family":"Kasap","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences\n                    Tepecik Education and Research Hospital, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nur","family":"\u0130pek","sequence":"additional","affiliation":[{"name":"Private Ege Pathology Laboratory, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Aky\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ege University, \u0130zmir\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"ref1","first-page":"2603","volume-title":"Epstein\u2013Barr Virus and its Replication. 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2322-7355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:40:57Z","timestamp":1730817657000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2322-7355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,8]]},"references-count":31,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,8,14]]},"published-print":{"date-parts":[[2024,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2322-7355","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,8]]},"published":{"date-parts":[[2024,5,8]]}}}