{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:36:52Z","timestamp":1764229012518,"version":"3.46.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Eine 2-j\u00e4hrige Norwegische Waldkatze wurde aufgrund von bilateralem, eitrigem\n                    Nasenausfluss und Stertor vorgestellt. Eine Computertomografie (CT) des Kopfes\n                    zeigte eine intranasale Masse der linken Nasenh\u00f6hle, die sich bis hinter die\n                    Tuben\u00f6ffnungen erstreckte und den Nasenrachen vollst\u00e4ndig verlegte. Die\n                    Rhinoskopie best\u00e4tigte eine rosafarbene, speckige Masse. In der CT zeigten sich\n                    beide Kompartimente des rechten Mittelohres mit weichteilisodensem Material\n                    gef\u00fcllt. Die kn\u00f6cherne Umrandung des Mittelohres war nicht ver\u00e4ndert. Nach\n                    endoskopisch gest\u00fctzter Er\u00f6ffnung des Trommelfells (Tympanozentese) erwies sich\n                    die F\u00fcllung in dem einsehbaren, dorsolateralen Kompartiment neben wei\u00dflichem,\n                    hochviskosem Sekret als klassisches polyp\u00f6ses Gewebe. Es wurde der Verdacht\n                    einer sekund\u00e4ren Otitis media aufgrund einer Abflussst\u00f6rung ge\u00e4u\u00dfert.<\/jats:p>\n                  <jats:p>Mit einem endoskopisch-interventionellem Zugang durch das Nasenloch wurde die\n                    nasopharyngeale Masse f\u00fcr die histopathologische Untersuchung sowie zur\n                    Wiederherstellung des nasalen Atemweges und zur Erm\u00f6glichung der Tubendrainage\n                    abgetragen. Im Gegensatz zu Katzen mit klassischen, malignen Neoplasien der\n                    Nasenh\u00f6hle zeigten sich bei dem Kater mehrere Ansatzpunkte der Zubildung und\n                    mehrere wellenf\u00f6rmige Erhebungen bilateral in der nasopharyngealen\n                    Schleimhaut.<\/jats:p>\n                  <jats:p>Die zytologische und histopathologische Untersuchung identifizierte die Masse als\n                    Pilzgranulom im Rahmen einer in Deutschland nur selten beobachteten\n                    Kryptokokken-Infektion. Die molekulargenetische Analyse best\u00e4tigte eine\n                    Infektion mit Cryptococcus neoformans var. grubii.<\/jats:p>\n                  <jats:p>Ein einmaliges intranasales und nasopharyngeales endoskopisches D\u00e9bridement hatte\n                    innerhalb von 14 Tagen zu einer deutlichen Verbesserung der klinischen Befunde\n                    und einer vollst\u00e4ndigen Ausheilung des rechten Mittelohres (inklusive des\n                    Trommelfells) gef\u00fchrt, jedoch nicht zu einer vollst\u00e4ndigen Heilung der\n                    Erkrankung. Der Kater wurde deshalb nach Erhalt des\n                    Cryptococcus-positiven Befundes \u00fcber mehrere Wochen mit oraler\n                    Itraconazol-L\u00f6sung therapiert.<\/jats:p>\n                  <jats:p>Der Fallbericht zeigt, dass auch in Deutschland die Kryptokokkose bei Katzen\n                    vorkommen kann. In der Endoskopie zeigt sich eine nasopharyngeale Masse mit\n                    multiplen Ansatzpunkten, was f\u00fcr eine Neoplasie untypisch ist. F\u00fcr eine Therapie\n                    ist neben der empfohlenen Entfernung der Masse nach aktuellem Wissensstand die\n                    orale Gabe von systemischen Antimykotika dringend anzuraten.<\/jats:p>","DOI":"10.1055\/a-2324-0887","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T18:45:03Z","timestamp":1719427503000},"page":"174-188","source":"Crossref","is-referenced-by-count":0,"title":["Differenzialdiagnose zur malignen Neoplasie: Nasopharyngeale Masse\n                    bei einer Katze mit nasaler Kryptokokkose in Deutschland"],"prefix":"10.1055","volume":"52","author":[{"given":"Sarah","family":"R\u00f6sch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule\n                    Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Rickerts","sequence":"additional","affiliation":[{"name":"Konsiliarlabor f\u00fcr Kryptokokkose und seltene Systemmykosen, Robert Koch\n                    Institut, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Miki\u0107","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule\n                    Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunja","family":"Wilmes","sequence":"additional","affiliation":[{"name":"Konsiliarlabor f\u00fcr Kryptokokkose und seltene Systemmykosen, Robert Koch\n                    Institut, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Beineke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Stiftung Tier\u00e4rztliche Hochschule\n                    Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Mischke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule\n                    Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1177\/1098612X21994396","article-title":"Comparison of CT features of 79 cats with intranasal mass lesions","volume":"23","author":"S Bouyssou","year":"2021","journal-title":"J Feline Med Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jfms.2010.07.009","article-title":"Inflammatory polyps of the nasal turbinates of cats: an argument for designation\n                    as feline mesenchymal nasal hamartoma","volume":"13","author":"V Greci","year":"2011","journal-title":"J Feline Med Surg"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/vru.13077","article-title":"CT findings of nasal cryptococcosis in cats and dogs: A case 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ECVIM-CA Congress; 2022","volume":"36","author":"S R\u00f6sch","year":"2022","journal-title":"Gothenburg: Journal of Veterinary Internal Medicine"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2324-0887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T07:31:19Z","timestamp":1764228679000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2324-0887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":44,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2024,6,26]]},"published-print":{"date-parts":[[2024,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2324-0887","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2024,6]]}}}