{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:31:09Z","timestamp":1790778669859,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background Sessile serrated lesions (SSLs) are associated with an increased risk of colorectal cancer. Data on the prevalence of SSLs in Asia are limited. We performed this study to estimate the prevalence of SSLs in Asia and to explore endoscopic factors that are associated with SSL detection.<\/jats:p><jats:p>\n            Methods This is a post-hoc analysis of a multicenter randomized controlled trial from four Asian countries\/regions that compared adenoma detection rates using linked-color imaging (LCI) and white-light imaging. Colonoscopies were performed in an average-risk population for screening, diagnostic examination, or polyp surveillance. Patients with SSLs were compared against those without SSLs to evaluate for possible predictors of SSL detection using Firth\u2019s logistic regression.<\/jats:p><jats:p>\n            Results 2898 participants (mean age 64.5 years) were included in the analysis. The estimated prevalence of SSLs was 4.0% (95%CI 3.4%\u20134.8%), with no sex or age group differences. On multivariable analysis, use of LCI (adjusted odds ratio [aOR] 1.63, 95%CI 1.10\u20132.41), experienced endoscopists (aOR 1.94, 95%CI 1.25\u20133.00), use of transparent cap (aOR 1.75, 95%CI 1.09\u20132.81), and longer withdrawal time (aOR 1.06, 95%CI 1.03\u20131.10) were independently associated with SSL detection. Synchronous adenoma detection (aOR 1.89, 95%CI 1.20\u20132.99) was also predictive of SSL detection.<\/jats:p><jats:p>\n            Conclusion The prevalence of SSLs in Asia is 4.0%. Use of LCI or\n      a transparent cap, greater endoscopist experience, and longer withdrawal time were all\n      associated with increased SSL detection.<\/jats:p>","DOI":"10.1055\/a-2324-6262","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:04:17Z","timestamp":1718060657000},"page":"684-693","source":"Crossref","is-referenced-by-count":10,"title":["Sessile serrated lesion prevalence and factors associated with their detection: a post-hoc analysis of a multinational randomized controlled trial from Asia"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-4340","authenticated-orcid":false,"given":"Chin Kimg","family":"Tan","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore"},{"name":"Medicine Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-1409","authenticated-orcid":false,"given":"Sho","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, International University of Health and Welfare School of Medicine, Narita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiing Leong","family":"Ang","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Changi General Hospital, Singapore, Singapore"},{"name":"Medicine Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan Han","family":"Koh","sequence":"additional","affiliation":[{"name":"Health Services Research, Changi General Hospital, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Mun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Changi General Hospital, Singapore, Singapore"},{"name":"Pathology Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satimai","family":"Aniwan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Endoscopy for Gastrointestinal Oncology, Chulalongkorn University Department of Internal Medicine, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Mo","family":"Chiu","sequence":"additional","affiliation":[{"name":"Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannikar","family":"Laohavichitra","sequence":"additional","affiliation":[{"name":"Rajavithi Digestive Endoscopy Center, Rajavithi Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakkarin","family":"Chirapongsathorn","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4994-016X","authenticated-orcid":false,"given":"Takeshi","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen Ya","family":"Kuo","sequence":"additional","affiliation":[{"name":"Gastroenterology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-9705","authenticated-orcid":false,"given":"Naohisa","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Takezawa","sequence":"additional","affiliation":[{"name":"Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-6886","authenticated-orcid":false,"given":"Rungsun","family":"Rerknimitr","sequence":"additional","affiliation":[{"name":"Center of Excellence in Endoscopy for Gastrointestinal Oncology, Chulalongkorn University Department of Internal Medicine, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Gastroenterology, Cancer Institute Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1136\/gutjnl-2017-314005","article-title":"British Society of Gastroenterology position statement on serrated polyps in the colon and rectum","volume":"66","author":"JE East","year":"2017","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1053\/j.gastro.2019.06.041","article-title":"Terminology, molecular 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