{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:03:00Z","timestamp":1789542180232,"version":"build-2803163510"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background Missed lesions are common during standard colonoscopy and are correlated with post-colonoscopy colorectal cancer. Contrast-enhanced technologies have recently been developed to improve polyp detection. We aimed to evaluate the impact of linked color imaging (LCI) on the proximal adenoma miss rate in routine colonoscopy.<\/jats:p><jats:p>\n            Methods This national, multicenter, tandem, randomized trial compared the outcomes of colonoscopy with white-light imaging (WLI) versus LCI for polyp detection in the right colon. Two consecutive examinations of the right colon (upstream of the hepatic flexure) were made with WLI and LCI by the same operator. First-pass examination by WLI or LCI was randomized 1:1 after cecal intubation. According to statistical calculations, 10 endoscopy units had to include approximately 700 patients. The primary outcome was proximal adenoma miss rate. Secondary outcomes were the proximal miss rates for sessile serrated lesions (SSL), advanced adenomas, and polyps.<\/jats:p><jats:p>\n            Results 764 patients were included from 1 January 2020 to 22 December 2022, and 686 patients were randomized (345 WLI first vs. 341 LCI first). Both groups were comparable in terms of demographics and indications. The proximal adenoma miss rate was not significantly higher in the WLI-first group (36.7%) vs. the LCI-first group (31.8%) (estimated mean absolute difference: 4.9% [95%CI \u20135.2% to 15.0%], P = 0.34). There was also no significant difference in miss rates for SSLs, advanced adenomas, and polyps in the proximal colon.<\/jats:p><jats:p>\n            Conclusions In contrast to previous data, this study does not support the benefit of LCI to the proximal adenoma miss rate in routine colonoscopy.<\/jats:p>","DOI":"10.1055\/a-2324-8807","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T23:30:20Z","timestamp":1715643020000},"page":"759-767","source":"Crossref","is-referenced-by-count":14,"title":["Impact of linked color imaging on the proximal adenoma miss rate: a multicenter tandem randomized controlled trial (the COCORICO trial)"],"prefix":"10.1055","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct04440865","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04112563","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-2814","authenticated-orcid":false,"given":"David","family":"Karsenti","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, P\u00f4le Digestif Paris Bercy, Clinique Paris-Bercy, Charenton-le-Pont, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-0310","authenticated-orcid":false,"given":"Guillaume","family":"Perrod","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Perrot","sequence":"additional","affiliation":[{"name":"UMR 1246 SPHERE (MethodS in Patient-centered outcomes and HEalth ResEarch), INSERM, Nantes University, Tours University, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille","family":"Qu\u00e9n\u00e9herv\u00e9","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Brest University Hospital, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Chabrun","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Clinique Saint-Joseph, Tr\u00e9laz\u00e9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Koch","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Besan\u00e7on University Hospital, Besancon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-9076","authenticated-orcid":false,"given":"Geoffroy","family":"Vanbiervliet","sequence":"additional","affiliation":[{"name":"P\u00f4le DIGi-TUNED, Endoscopie Digestive, Centre Hospitalier Universitaire de Nice, H\u00f4pital L\u2019Archet 2, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Rahmi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Velut","sequence":"additional","affiliation":[{"name":"Center for Digestive Endoscopy, Sorbonne University, Saint Antoine Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"Moreno-Garcia","sequence":"additional","affiliation":[{"name":"Research and Development Unit, French Society of Digestive Endoscopy, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryan","family":"Cavicchi","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, P\u00f4le Digestif Paris Bercy, Clinique Paris-Bercy, Charenton-le-Pont, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Dray","sequence":"additional","affiliation":[{"name":"Center for Digestive Endoscopy, Sorbonne University, Saint Antoine Hospital, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1056\/NEJMoa1309086","article-title":"Adenoma detection rate and risk of colorectal cancer and death","volume":"370","author":"DA Corley","year":"2014","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1177\/2050640617700014","article-title":"Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative","volume":"49","author":"MF Kaminski","year":"2017","journal-title":"Endoscopy"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/ajg.2009.104","article-title":"American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]","volume":"104","author":"DK Rex","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.gie.2011.02.023","article-title":"Likelihood of missed and recurrent adenomas in the proximal versus the distal colon","volume":"74","author":"AO Laiyemo","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1055\/a-2003-1068","article-title":"Proximal serrated polyp detection rate and post-colonoscopy colorectal cancer: the missing link","volume":"55","author":"JEG IJspeert","year":"2023","journal-title":"Endoscopy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1055\/a-1974-9979","article-title":"Comparison of adenoma detection rate and proximal serrated polyp detection rate and their effect on post-colonoscopy colorectal cancer mortality in screening patients","volume":"55","author":"J Zessner-Spitzenberg","year":"2023","journal-title":"Endoscopy"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1055\/a-0580-7405","article-title":"Linked color imaging reduces the miss rate of neoplastic lesions in the right colon: a randomized tandem colonoscopy study","volume":"50","author":"S Paggi","year":"2018","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.gie.2017.02.035","article-title":"Comparison of linked color imaging and white-light colonoscopy for detection of colorectal polyps: a multicenter, randomized, crossover trial","volume":"86","author":"M Min","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.gie.2020.05.044","article-title":"Linked-color imaging versus white-light colonoscopy in an organized colorectal cancer screening program","volume":"92","author":"S Paggi","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/00365521.2020.1786850","article-title":"Improved adenoma detection with linked color imaging technology compared to white-light colonoscopy","volume":"55","author":"BD Lov\u00e1sz","year":"2020","journal-title":"Scand J Gastroenterol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1111\/codi.15605","article-title":"Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: a randomized controlled trial","volume":"23","author":"T Kudo","year":"2021","journal-title":"Colorectal Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.gie.2019.06.045","article-title":"Impact of linked-color imaging on colorectal adenoma detection","volume":"90","author":"CE Oliveira Dos Santos","year":"2019","journal-title":"Gastrointest Endosc"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1111\/jgh.15539","article-title":"Linked color imaging versus white light imaging colonoscopy for colorectal adenoma detection: a randomized controlled trial","volume":"36","author":"K Miyaguchi","year":"2021","journal-title":"J Gastroenterol Hepatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.cgh.2021.04.004","article-title":"Detection of colorectal neoplasms using linked color imaging: a prospective, randomized, tandem colonoscopy trial","volume":"19","author":"I Hasegawa","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cgh.2022.03.033","article-title":"Colorectal sessile serrated lesion detection using linked color imaging: a multicenter, parallel randomized controlled trial","volume":"21","author":"J Li","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1272\/jnms.JNMS.2023_90-117","article-title":"Comparison of linked color imaging and white light imaging colonoscopy for detection of colorectal adenoma requiring endoscopic treatment: a single-center randomized controlled trial","volume":"90","author":"S Tanaka","year":"2023","journal-title":"J Nippon Med Sch"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/den.13613","article-title":"Colon polyp detection using linked color imaging compared to white light imaging: systematic review and meta-analysis","volume":"32","author":"S Shinozaki","year":"2020","journal-title":"Dig Endosc"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"67","DOI":"10.15403\/jgld-4027","article-title":"The effect of linked color imaging for adenoma detection. A meta-analysis of randomized controlled studies","volume":"31","author":"J Wang","year":"2022","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231196636","article-title":"Linked color imaging versus white light imaging in the diagnosis of colorectal\n          lesions: a meta-analysis of randomized controlled trials","volume":"16","author":"Y Sun","year":"2023","journal-title":"Therap Adv Gastroenterol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.gie.2008.05.057","article-title":"The Boston Bowel Preparation Scale: a valid and reliable instrument for colonoscopy-oriented research","volume":"69","author":"EJ Lai","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/s0016-5107(03)02159-x","article-title":"The Paris endoscopic classification of superficial neoplastic lesions: esophagus,\n          stomach, and colon: November 30 to December 1, 2002","volume":"58","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/ajg.2012.161","article-title":"Serrated lesions of the colorectum: review and recommendations from an expert panel","volume":"107","author":"DK Rex","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1136\/gut.47.2.251","article-title":"The Vienna classification of gastrointestinal epithelial neoplasia","volume":"47","author":"RJ Schlemper","year":"2000","journal-title":"Gut"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/gut.2009.179804","article-title":"Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002).","volume":"59","author":"SR Cairns","year":"2010","journal-title":"Gut"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.gie.2010.06.068","article-title":"Comprehensive validation of the Boston Bowel Preparation Scale","volume":"72","author":"AH Calderwood","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.gie.2015.01.035","article-title":"Position change during colonoscope withdrawal increases polyp and adenoma detection in the right but not in the left side of the colon: results of a randomized controlled trial","volume":"82","author":"AJ Ball","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"E1391","DOI":"10.1055\/a-1896-4499","article-title":"Second exam of right colon improves adenoma detection rate: systematic review and meta-analysis of randomized controlled trials","volume":"10","author":"F Kamal","year":"2022","journal-title":"Endosc Int Open"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1007\/s10620-019-05808-y","article-title":"Difference in physician- and patient-dependent factors contributing to adenoma detection rate and serrated polyp detection rate","volume":"64","author":"M Cavicchi","year":"2019","journal-title":"Dig Dis Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cgh.2022.10.021","article-title":"Linked-color imaging detects more colorectal adenoma and serrated lesions: an international randomized controlled trial","volume":"21","author":"S Suzuki","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.gie.2019.06.031","article-title":"Linked color imaging versus narrow-band imaging for colorectal polyp detection: a prospective randomized tandem colonoscopy study","volume":"91","author":"WK Leung","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1055\/a-1995-2685","article-title":"Colorectal sessile serrated lesion detection using linked-color imaging versus narrow-band imaging: a parallel randomized controlled trial","volume":"55","author":"J Li","year":"2023","journal-title":"Endoscopy"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1055\/a-2129-7254","article-title":"Texture and color enhancement imaging versus high definition white-light endoscopy for detection of colorectal neoplasia: a randomized trial","volume":"55","author":"G Antonelli","year":"2023","journal-title":"Endoscopy"},{"key":"ref33","first-page":"268","article-title":"Designs of colonoscopic adenoma detection trials: more positive results with tandem than with parallel studies \u2013 an analysis of studies on imaging techniques and mechanical devices","volume":"70","author":"K Zimmermann-Fraedrich","year":"2021","journal-title":"Gut"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2324-8807.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:31:10Z","timestamp":1730806270000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2324-8807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,9,27]]},"published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2324-8807","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,13]]},"published":{"date-parts":[[2024,5,13]]}}}