{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:44:54Z","timestamp":1772804694620,"version":"3.50.1"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Aim Cardiac rhabdomyoma, known as the most common benign cardiac tumor in\n                    childhood, is strongly associated with tuberous sclerosis complex. This study\n                    aims to present our single-center experience regarding clinical observations,\n                    diagnostic approaches, and treatment modalities for cardiac rhabdomyoma\n                    identified during the neonatal period.<\/jats:p><jats:p>\n          Patients and Methods In this clinical observational study, we\n                    retrospectively assessed the outcomes of 12 newborn patients diagnosed with\n                    cardiac rhabdomyoma who were followed up in our neonatal intensive care unit\n                    over the past 12 years.<\/jats:p><jats:p>\n          Results The mean gestational age of the patients was 38.2\u00b11.6 weeks, with\n                    an average birth weight of 3193\u00b1314 grams. The mean postnatal age at initial\n                    diagnosis was 12.42\u00b115.75 days. Tuberous sclerosis complex was clinically\n                    identified in 50% of cases (six patients). Seven infants received everolimus\n                    treatment, while three infants underwent clinical monitoring without specific\n                    interventions. A significant reduction in cardiac mass size was observed in all\n                    surviving patients, leading to their subsequent discharge from the hospital.<\/jats:p><jats:p>\n          Conclusion Cardiac rhabdomyomas often undergo spontaneous regression in\n                    early childhood. However, in cases with obstructive lesions or arrhythmias, they\n                    may present life-threatening consequences. Timely diagnosis, appropriate\n                    clinical management, and monitoring are crucial in optimizing outcomes for\n                    neonates with cardiac rhabdomyoma.<\/jats:p>","DOI":"10.1055\/a-2325-5490","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T22:49:23Z","timestamp":1718318963000},"page":"520-527","source":"Crossref","is-referenced-by-count":1,"title":["Neonatal Cardiac Rhabdomyoma: A Single-Center\n                    Experience"],"prefix":"10.1055","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-1174","authenticated-orcid":false,"given":"Ba\u015fak","family":"Kaya","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child Health and\n                    Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Akduman","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child Health and\n                    Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Dilli","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child Health and\n                    Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lker Ufuk","family":"Say\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology, SBU Ankara Dr Sami Ulus Maternity Child Health\n                    and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Kunt","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child Health and\n                    Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merve","family":"Do\u011fang\u00f6n\u00fcl","sequence":"additional","affiliation":[{"name":"Pediatrics, SBU Ankara Dr Sami Ulus Maternity Child Health and Diseases\n                    Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcrses","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, SBU Ankara Dr Sami\n                    Ulus Maternity Child Health and Diseases Training and Research Hospital, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer Nuri","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Surgery, SBU Ankara Dr Sami Ulus Maternity\n                    Child Health and Diseases Training and Research Hospital, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"U\u00e7an","sequence":"additional","affiliation":[{"name":"Pediatric Radiology, SBU Ankara Dr Sami Ulus Maternity Child Health and\n                    Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015feg\u00fcl","family":"Zenciro\u011flu","sequence":"additional","affiliation":[{"name":"Neonatology, SBU Ankara Dr Sami Ulus Maternity Child Health and\n                    Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1177\/2150135117723904","article-title":"Cardiac tumors in pediatric patients: A systematic review","volume":"8","author":"A Tzani","year":"2017","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"ref2","first-page":"48","article-title":"Cardiac rhabdomyoma in intrauterine life: clinical features and natural history.\n                    A case series and review of published reports","volume":"3","author":"S Pipitone","year":"2002","journal-title":"Ital Heart J"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.pedneo.2016.07.004","article-title":"Fetal primary cardiac tumors during perinatal period","volume":"58","author":"S M Yuan","year":"2017","journal-title":"Pediatr Neonatol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00246-003-0590-4","article-title":"Fetal and neonatal cardiac tumors","volume":"25","author":"H Isaacs","year":"2004","journal-title":"Pediatr Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/exmp.2000.2331","article-title":"Cardiac rhabdomyomas exhibit a fetal pattern of atrial natriuretic peptide\n                    immunoreactivity","volume":"70","author":"L A Benvenuti","year":"2001","journal-title":"Exp Mol Pathol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1017\/S1047951109992046","article-title":"Considerations for prenatal counselling of patients with cardiac rhabdomyomas\n                    based on their cardiac and neurologic outcomes","volume":"20","author":"S C Degueldre","year":"2010","journal-title":"Cardiol Young"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1007\/s00246-010-9731-9738","article-title":"Sudden death of a young child due to cardiac rhabdomyoma","volume":"31","author":"A Gupta","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1016\/s0828-282x(10)70009-x","article-title":"Benign cardiac tumours, malignant arrhythmias","volume":"26","author":"K A Myers","year":"2010","journal-title":"Can J Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.jacc.2011.08.005","article-title":"Cardiac tumors and associated arrhythmias in pediatric patients, with\n                    observations on surgical therapy for ventricular tachycardia","volume":"58","author":"C Y Miyake","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e2019125","DOI":"10.4322\/acr.2019.125.","article-title":"Multiple cardiac rhabdomyomas in tuberous sclerosis complex: case report and\n                    review of the literature","volume":"9","author":"P Frudit","year":"2019","journal-title":"Autops Case Rep"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"mmt013","DOI":"10.1093\/mmcts\/mmt013","article-title":"Primary cardiac tumours in the paediatric population","volume":"2013","author":"L Careddu","year":"2013","journal-title":"Multimed Man Cardiothorac Surg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1590\/abd1806-4841.20186972","article-title":"Tuberous sclerosis complex: review based on new diagnostic criteria","volume":"93","author":"LK L Portocarrero","year":"2018","journal-title":"An Bras Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.17826\/cutf.254611","article-title":"Cardiac rhabdomyoma associated with tuberosclerosis complex in a newborn","volume":"41","author":"B T\u00f6rer","year":"2016","journal-title":"Cukurova Med J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2021.07.011","article-title":"Updated International Tuberous Sclerosis Complex Diagnostic Criteria and\n                    Surveillance and Management Recommendations","volume":"123","author":"International Tuberous Sclerosis Complex Consensus\n                            Group","year":"2021","journal-title":"Pediatr Neurol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.24953\/turkjped.2022.922","article-title":"Cardiac rhabdomyomas: clinical progression, efficacy and safety of everolimus\n                    treatment","volume":"65","author":"S Y\u0131ld\u0131r\u0131m","year":"2023","journal-title":"Turk J Pediatr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1002\/ajmg.a.62120","article-title":"Everolimus for severe arrhythmias in tuberous sclerosis complex related cardiac\n                    rhabdomyomas","volume":"185","author":"M P Silva-S\u00e1nchez","year":"2021","journal-title":"Am J Med Genet A"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e0158476","DOI":"10.1371\/journal.pone.0158476","article-title":"Long-term use of everolimus in patients with tuberous sclerosis complex: final\n                    results from the EXIST-1 study","volume":"11","author":"D N Franz","year":"2016","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/archdischild-2013-304948","article-title":"Annual review of children with tuberous sclerosis","volume":"100","author":"K H Ng","year":"2015","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/uog.5264","article-title":"Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a\n                    meta-analysis","volume":"31","author":"A S Chao","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1067\/S0022-3476(03)00494-3","article-title":"Fetal rhabdomyoma: prenatal diagnosis, clinical outcome, and incidence of\n                    associated tuberous sclerosis complex","volume":"143","author":"R S Bader","year":"2003","journal-title":"J Pediatr"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"8712962","DOI":"10.1155\/2016\/8712962","article-title":"Regression of cardiac rhabdomyomas in a neonate after everolimus treatment","volume":"2016","author":"H Bornaun","year":"2016","journal-title":"Case Rep Pediatr"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1177\/2150135114561689","article-title":"Biventricular repair in a neonate with obstructive inflow cardiac rhabdomyoma\n                    and tuberous sclerosis","volume":"6","author":"H W Hood","year":"2015","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/s0003-4975(98)00180-5","article-title":"Cardiac rhabdomyomas and obstructive left heart disease: histologically but not\n                    functionally benign","volume":"65","author":"M D Black","year":"1998","journal-title":"Ann Thorac Surg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.jacc.2011.08.005","article-title":"Cardiac tumors and associated arrhythmias in pediatric patients, with\n                    observations on surgical therapy for ventricular tachycardia","volume":"58","author":"C Y Miyake","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/uog.5264.","article-title":"Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a\n                    meta-analysis","volume":"31","author":"A S Chao","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1080\/14767058.2019.1597044.","article-title":"Perinatal unusual rhabdomyoma location- case report and systematic reviews of\n                    the literature","volume":"34","author":"Pinto VC Cavalcante CTMB","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S1470-2045(05)70093-0","article-title":"Cardiac tumors: Diagnosis and management","volume":"6","author":"J Butany","year":"2005","journal-title":"Lancet Oncol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1750-1172-2-11","article-title":"Cardiac tumours in children","volume":"2","author":"O Uzun","year":"2007","journal-title":"Orphanet J Rare Dis"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1046\/j.1440-1754.2000.00443.x","article-title":"Pre-excitation syndrome secondary to cardiac rhabdomyomas in tuberous\n                    sclerosis","volume":"36","author":"C Mas","year":"2000","journal-title":"J Paediatr Child Health"},{"key":"ref30","first-page":"374","article-title":"Perinatal management of cardiac tumors: a case series","volume":"68","author":"A Amelia","year":"2013","journal-title":"Med J Malaysia"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3928\/19382359-20170320-01","article-title":"Tuberous sclerosis complex: a review","volume":"46","author":"S C Randle","year":"2017","journal-title":"Pediatr Ann"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF02722750","article-title":"Cardiac rhabdomyoma and tuberous sclerosis: Prenatal diagnosis and\n                    follow-up","volume":"70","author":"B B Dass","year":"2003","journal-title":"Indian J Pediatr"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ejpn.2007.06.006","article-title":"Prenatal diagnosis of cerebral lesions in ruberous sclerosis complex (TSC). Case\n                    report and review of the literature","volume":"12","author":"S B Wortmann","year":"2008","journal-title":"Eur J Paediatr Neurol"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s13023-022-02266-0","article-title":"Perfect match: mTOR inhibitors and tuberous sclerosis complex","volume":"17","author":"C Luo","year":"2022","journal-title":"Orphanet J Rare Dis"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/jdv.13356","article-title":"Systemic effects of treatment with mTOR inhibitors in tuberous sclerosis\n                    complex: a comprehensive review","volume":"30","author":"K Sadowski","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.pcl.2015.03.005","article-title":"Tuberous sclerosis complex","volume":"62","author":"F J DiMario","year":"2015","journal-title":"Pediatr Clin North Am"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/archdischild-2013-304948","article-title":"Annual review of children with tuberous sclerosis","volume":"100","author":"K H Ng","year":"2015","journal-title":"Arch Dis Child Educ Pract Ed"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.pediatrneurol.2016.07.003","article-title":"Applying the lessons of tuberous sclerosis: the 2015 Hower Award Lecture","volume":"63","author":"E S Roach","year":"2016","journal-title":"Pediatr Neurol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/pde.12567.","article-title":"Tuberous Sclerosis Complex: An Update for Dermatologists","volume":"32","author":"S K Jacks","year":"2015","journal-title":"Pediatr Dermatol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"Tuberous sclerosis complex diagnostic criteria update: recommendations of the\n                    2012 International Tuberous Sclerosis Complex Consensus Conference","volume":"49","author":"International Tuberous Sclerosis Complex Consensus\n                            Group","year":"2013","journal-title":"Pediatr Neurol"},{"key":"ref42","first-page":"51","article-title":"T\u00fcberoskleroz kompleksi; Tek merkez deneyimi","volume":"50","author":"\u0130 Erol","year":"2015","journal-title":"T\u00fcrk Ped Ar\u015f"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","article-title":"Neurological and neuropsychiatric aspects of tuberous sclerosis complex","volume":"14","author":"P Curatolo","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e20164040","DOI":"10.1542\/peds.2016-4040","article-title":"Presentation and diagnosis of tuberous sclerosis complex in infants","volume":"140","author":"P E Davis","year":"2017","journal-title":"Pediatrics"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.pediatrneurol.2021.12.012","article-title":"Tuber brain proportion determines epilepsy onset in children with tuberous\n                    sclerosis complex","volume":"129","author":"F Zhang","year":"2021","journal-title":"Pediatr Neurol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.yebeh.2017.09.010","article-title":"Efficacy and safety of vigabatrin in Japanese patients with infantile spasms:\n                    primary short-term study and extension study","volume":"78","author":"Y Ohtsuka","year":"2018","journal-title":"Epilepsy Behav"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00383-007-1875-0","article-title":"Cardiac rhabdomyoma as an unusual mediastinal mass in a newborn","volume":"23","author":"I Karnak","year":"2007","journal-title":"Pediatr Surg Int"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/ana.24523","article-title":"Everolimus for subependymal giant cell astrocytoma: 5-year final analysis","volume":"78","author":"D N Franz","year":"2015","journal-title":"Ann Neurol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1016\/S0140-6736(16)31419-2","article-title":"Adjunctive everolimus therapy for treatment-resistant focal-onset seizures\n                    associated with tuberous sclerosis (EXIST-3): a phase 3, randomised,\n                    double-blind, placebo-controlled study","volume":"388","author":"J A French","year":"2016","journal-title":"Lancet"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2165\/11634580-000000000-00000","article-title":"Topical rapamycin therapy to alleviate the cutaneous manifestations of tuberous\n                    sclerosis complex: a double-blind, randomized, controlled trial to evaluate the\n                    safety and efficacy of topically applied rapamycin","volume":"12","author":"M K Koenig","year":"2012","journal-title":"Drugs R D"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1542\/peds.2011-3476","article-title":"Everolimus: a challenging drug in the treatment of multifocal inoperable cardiac\n                    rhabdomyoma","volume":"130","author":"H A Demir","year":"2012","journal-title":"Pediatrics"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/S2352-","article-title":"Adjunctive everolimus for children and adolescents with treatment-refractory\n                    seizures associated with tuberous sclerosis complex: post-hoc analysis of the\n                    phase 3 EXIST-3 trial","volume":"2","author":"P Curatolo","year":"2018","journal-title":"Lancet Child Adolesc Heal"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejpn.2013.03.002","article-title":"Long-term effect of everolimus on epilepsy and growth in children under 3 years\n                    of age treated for subependymal giant cell astrocytoma associated with tuberous\n                    sclerosis complex","volume":"17","author":"K Kotulska","year":"2013","journal-title":"Eur J Paediatr Neurol"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2325-5490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T23:51:46Z","timestamp":1733183506000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2325-5490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,13]]},"references-count":52,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2024,12,2]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2325-5490","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,13]]}}}