{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:03:25Z","timestamp":1790327005877,"version":"4.1.0"},"reference-count":83,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation","award":["L232117"],"award-info":[{"award-number":["L232117"]}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170309"],"award-info":[{"award-number":["82170309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>The consensus guidelines of the Geriatric Society of Chinese Medical Association on the management of atrial fibrillation (AF) in the elderly was first published in 2011 and updated in 2016, with endorsement by Chinese Society of Geriatric Health Medicine. Since then, many important studies regarding the screening and treatment in the elderly population have been reported, necessitating this updated expert consensus guideline. The writing committee members comprehensively reviewed updated evidence pertaining to elderly patients with AF, and formulated this 2024 update. The highlighted issues focused on the following: screening for AF, geriatric comprehensive assessment, use of the Atrial fibrillation Better Care (ABC) pathway for the elderly patients, and special clinical settings related to elderly patients with AF. New recommendations addressing smart technology facilitated AF screening, ABC pathway based management, and optimal anticoagulation were developed, with a focus on the elderly.<\/jats:p>","DOI":"10.1055\/a-2325-5923","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T19:14:00Z","timestamp":1715714040000},"page":"897-911","source":"Crossref","is-referenced-by-count":112,"title":["2024 Chinese Expert Consensus Guidelines on the Diagnosis and Treatment of Atrial Fibrillation in the Elderly, Endorsed by Geriatric Society of Chinese Medical Association (Cardiovascular Group) and Chinese Society of Geriatric Health Medicine (Cardiovascular Branch): Executive Summary"],"prefix":"10.1055","volume":"124","author":[{"given":"Yutang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Medical Center, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-7751","authenticated-orcid":false,"given":"Yutao","family":"Guo","sequence":"additional","affiliation":[{"name":"Pulmonary Vessel and Thrombotic Disease, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhao","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Taikang Yanyuan Rehabilitation Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tang","sequence":"additional","affiliation":[{"name":"Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Geriatric Center, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Medical Center, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Medical Center, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom"},{"name":"Department of Clinical Medicine, Danish Center for Health Services Research, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Expert Reviewers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"ref1","first-page":"894","article-title":"Expert consensus on the management of atrial fibrillation in elderly population (2011), endorsed by Geriatric Society of Chinese Medical Association (Cardiovascular Group)","volume":"30","author":"X Li","year":"2011","journal-title":"Chin J Geriatric"},{"key":"ref2","first-page":"14","article-title":"Expert consensus on the management of atrial fibrillation in elderly population (2016), endorsed by Geriatric Society of Chinese Medical Association (Cardiovascular Group) and Chinese Society of Geriatric Health Medicine","volume":"35","author":"M Qing","year":"2016","journal-title":"Chin J Geriatric"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ccep.2020.10.010","article-title":"Epidemiology of atrial fibrillation: geographic\/ecological risk factors, age, sex, genetics","volume":"13","author":"J Zhang","year":"2021","journal-title":"Card Electrophysiol Clin"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1378\/chest.14-0321","article-title":"Prevalence, incidence, and lifetime risk of atrial fibrillation in China: new insights into the global burden of atrial fibrillation","volume":"147","author":"Y Guo","year":"2015","journal-title":"Chest"},{"key":"ref6","first-page":"100439","article-title":"Prevalence and risk of atrial fibrillation in China: a national cross-sectional epidemiological study","volume":"23","author":"S Shi","year":"2022","journal-title":"Lancet Reg Health West Pac"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"e024319","DOI":"10.1161\/JAHA.121.024319","article-title":"Effects of the Atrial Fibrillation Better Care Pathway on outcomes among clinically complex Chinese patients with atrial fibrillation with multimorbidity and polypharmacy: a report from the ChiOTEAF registry","volume":"11","author":"A Kotalczyk","year":"2022","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1055\/s-0042-1756355","article-title":"Clinical complexity domains, anticoagulation, and outcomes in patients with atrial fibrillation: a report from the GLORIA-AF registry phase II and III","volume":"122","author":"G F Romiti","year":"2022","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/s-0043-1769735","article-title":"The impact of polypharmacy on the effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation","volume":"124","author":"M Grymonprez","year":"2024","journal-title":"Thromb Haemost"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1770724","article-title":"Effect of oral anticoagulants in atrial fibrillation patients with polypharmacy: a meta-analysis","author":"Y Zheng","year":"2023","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/ehjqcco\/qcab054","article-title":"Poor adherence to guideline-directed anticoagulation in elderly Chinese patients with atrial fibrillation: a report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry","volume":"9","author":"Y Guo","year":"2023","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1055\/s-0042-1750385","article-title":"Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: executive summary of a European and Asia-Pacific Expert Consensus Paper","volume":"122","author":"D A Gorog","year":"2022","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1055\/s-0040-1718729","article-title":"The East Asian Paradox: an updated position statement on the challenges to the current antithrombotic strategy in patients with cardiovascular disease","volume":"121","author":"H K Kim","year":"2021","journal-title":"Thromb Haemost"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1055\/a-2278-8769","article-title":"Racial differences in ischemic and hemorrhagic stroke: an ecological epidemiological study","author":"D S Kang","year":"2024","journal-title":"Thromb Haemost"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/a-2269-1123","article-title":"Racial differences in bleeding risk: an ecological epidemiological study comparing Korea and United Kingdom subjects","author":"D S Kang","year":"2024","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.amjmed.2023.09.012","article-title":"Impact of unhealthy lifestyles on patients with atrial fibrillation at low risk of stroke: a nationwide cohort study","volume":"137","author":"S Kwon","year":"2024","journal-title":"Am J Med"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"J A Joglar","year":"2024","journal-title":"Circulation"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"e750","DOI":"10.1161\/CIR.0000000000000748","article-title":"Lifestyle and risk factor modification for reduction of atrial fibrillation: a scientific statement from the American Heart Association","volume":"141","author":"M K Chung","year":"2020","journal-title":"Circulation"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00380-019-01535-6","article-title":"Comparison of continuous 24-h and 14-day monitoring for detection of otherwise unknown atrial fibrillation: a registry to identify Japanese concealed atrial fibrillation (REAL-AF)-based study","volume":"35","author":"K Nagashima","year":"2020","journal-title":"Heart Vessels"},{"issue":"19","key":"ref21","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.jacc.2019.08.019","article-title":"Mobile photoplethysmographic technology to detect atrial fibrillation","volume":"74","author":"Y Guo","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2147\/NSS.S323286","article-title":"A single-center validation of the accuracy of a photoplethysmography-based smartwatch for screening obstructive sleep apnea","volume":"13","author":"Y Chen","year":"2021","journal-title":"Nat Sci Sleep"},{"issue":"19","key":"ref23","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/CIRCULATIONAHA.122.060291","article-title":"Detection of atrial fibrillation in a large population using wearable devices: the Fitbit Heart Study","volume":"146","author":"S A Lubitz","year":"2022","journal-title":"Circulation"},{"issue":"06","key":"ref24","first-page":"737","article-title":"Consumer-led screening for atrial fibrillation: a report from the mAFA-II trial long-term extension cohort","volume":"2","author":"Y Guo","year":"2022","journal-title":"JACC Asia"},{"issue":"07","key":"ref25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s11886-023-01898-3","article-title":"Sensitivity and specificity of wearables for atrial fibrillation in elderly populations: a systematic review","volume":"25","author":"F Babar","year":"2023","journal-title":"Curr Cardiol Rep"},{"issue":"03","key":"ref26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1055\/s-0039-3401823","article-title":"Lower versus standard INR targets in atrial fibrillation: a systematic review and meta-analysis of randomized controlled trials","volume":"120","author":"A K Pandey","year":"2020","journal-title":"Thromb Haemost"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejim.2021.05.038","article-title":"Device-detected atrial high rate episodes and the risk of stroke\/thrombo-embolism and atrial fibrillation incidence: a systematic review and meta-analysis","volume":"92","author":"M Vitolo","year":"2021","journal-title":"Eur J Intern Med"},{"issue":"13","key":"ref28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1056\/NEJMoa2303062","article-title":"Anticoagulation with edoxaban in patients with atrial high-rate episodes","volume":"389","author":"P Kirchhof","year":"2023","journal-title":"N Engl J Med"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/eurheartj\/ehad771","article-title":"Anticoagulation with edoxaban in patients with long atrial high-rate episodes \u226524\u2009h","volume":"45","author":"N Becher","year":"2024","journal-title":"Eur Heart J"},{"issue":"03","key":"ref30","first-page":"11","article-title":"Atrial high-rate episodes detected by cardiac implantable electronic devices: dynamic changes in episodes and predictors of incident atrial fibrillation","volume":"11","author":"J F Imberti","year":"2022","journal-title":"Biology (Basel)"},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa2310234","article-title":"Apixaban for stroke prevention in subclinical atrial fibrillation","volume":"390","author":"J S Healey","year":"2024","journal-title":"N Engl J Med"},{"issue":"13","key":"ref32","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/CIRCULATIONAHA.123.067512","article-title":"Direct oral anticoagulants for stroke prevention in patients with device-detected atrial fibrillation: a study-level meta-analysis of the NOAH-AFNET 6 and ARTESiA trials","volume":"149","author":"W F McIntyre","year":"2024","journal-title":"Circulation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"100786","DOI":"10.1016\/j.lanepe.2023.100786","article-title":"Atrial fibrillation: epidemiology, screening and digital health","volume":"37","author":"D Linz","year":"2024","journal-title":"Lancet Reg Health Eur"},{"issue":"11","key":"ref34","first-page":"51","article-title":"Mobile health technology integrated care in older atrial fibrillation patients: a subgroup analysis of the mAFA-II randomised clinical trial","volume":"51","author":"Y Guo","year":"2022","journal-title":"Age Ageing"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"e2140071","DOI":"10.1001\/jamanetworkopen.2021.40071","article-title":"The effects of implementing a mobile health-technology supported pathway on atrial fibrillation-related adverse events among patients with multimorbidity: the mAFA-II randomized clinical trial","volume":"4","author":"Y Yao","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"09","key":"ref36","doi-asserted-by":"crossref","first-page":"e14031","DOI":"10.1111\/eci.14031","article-title":"Mobile health technology integrated care in atrial fibrillation patients with diabetes mellitus in China: a subgroup analysis of the mAFA-II cluster randomized clinical trial","volume":"53","author":"Y Guo","year":"2023","journal-title":"Eur J Clin Invest"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejim.2022.11.002","article-title":"Mobile health-technology integrated care in atrial fibrillation patients with heart failure: a report from the mAFA-II randomized clinical trial","volume":"107","author":"Y Guo","year":"2023","journal-title":"Eur J Intern Med"},{"issue":"04","key":"ref38","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s11739-023-03249-0","article-title":"Mobile health-technology integrated care in secondary prevention atrial fibrillation patients: a post-hoc analysis from the mAFA-II randomized clinical trial","volume":"18","author":"Y Guo","year":"2023","journal-title":"Intern Emerg Med"},{"issue":"03","key":"ref39","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1055\/a-1515-9630","article-title":"Adherence to the 'Atrial Fibrillation Better Care' pathway in patients with atrial fibrillation: impact on clinical outcomes-a systematic review and meta-analysis of 285,000 patients","volume":"122","author":"G F Romiti","year":"2022","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"e29408","DOI":"10.2196\/29408","article-title":"Cost-effectiveness of mobile health-based integrated care for atrial fibrillation: model development and data analysis","volume":"24","author":"X Luo","year":"2022","journal-title":"J Med Internet Res"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcad055","article-title":"Estimating the impact of implementing an integrated care management approach with Atrial fibrillation Better Care (ABC) pathway for patients with atrial fibrillation in England from 2020-2040","author":"E M Camacho","year":"2023","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2024.02.011","article-title":"Dynamic assessment of CHA2DS2-VASc and HAS-BLED scores for predicting ischemic stroke and major bleeding in atrial fibrillation patients","author":"M J Serna","year":"2024","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"07","key":"ref43","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1055\/s-0039-1683933","article-title":"Incident co-morbidities in patients with atrial fibrillation initially with a CHA2DS2-VASc score of 0 (Males) or 1 (females): implications for reassessment of stroke risk in initially 'low-risk' patients","volume":"119","author":"T F Chao","year":"2019","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.amjmed.2017.09.009","article-title":"Comparing bleeding risk assessment focused on modifiable risk factors only versus validated bleeding risk scores in atrial fibrillation","volume":"131","author":"Y Guo","year":"2018","journal-title":"Am J Med"},{"issue":"04","key":"ref45","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1055\/s-0038-1636534","article-title":"Incident risk factors and major bleeding in patients with atrial fibrillation treated with oral anticoagulants: a comparison of baseline, follow-up and delta HAS-BLED scores with an approach focused on modifiable bleeding risk factors","volume":"118","author":"T F Chao","year":"2018","journal-title":"Thromb Haemost"},{"issue":"07","key":"ref46","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/ehjqcco\/qcab069","article-title":"Comparison of HAS-BLED and ORBIT bleeding risk scores in atrial fibrillation patients treated with non-vitamin K antagonist oral anticoagulants: a report from the ESC-EHRA EORP-AF General Long-Term Registry","volume":"8","author":"M Proietti","year":"2022","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1055\/s-0038-1675400","article-title":"Predicting thromboembolic and bleeding event risk in patients with non-valvular atrial fibrillation: a systematic review","volume":"118","author":"E D Borre","year":"2018","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.amjmed.2020.03.019","article-title":"Regular bleeding risk assessment associated with reduction in bleeding outcomes: the mAFA-II randomized trial","volume":"133","author":"Y Guo","year":"2020","journal-title":"Am J Med"},{"issue":"04","key":"ref49","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/geront\/gnac057","article-title":"Assessing patterns and stability of ADL hierarchical scales for functional disability assessment","volume":"63","author":"J H Fong","year":"2023","journal-title":"Gerontologist"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"146775","DOI":"10.1016\/j.gene.2022.146775","article-title":"The Japan Frailty Scale is a promising screening test for frailty and pre-frailty in Japanese elderly people","volume":"844","author":"R Egashira","year":"2022","journal-title":"Gene"},{"issue":"03","key":"ref51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.gerinurse.2019.11.012","article-title":"Reference value for the TUGT in healthy older people: a systematic review and meta-analysis","volume":"41","author":"J Long","year":"2020","journal-title":"Geriatr Nurs"},{"issue":"01","key":"ref52","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/s12888-021-03495-6","article-title":"A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study","volume":"21","author":"X Jia","year":"2021","journal-title":"BMC Psychiatry"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.amjcard.2022.10.031","article-title":"Association between concurrent use of amiodarone and DOACs and risk of bleeding in patients with atrial fibrillation","volume":"186","author":"M Shurrab","year":"2023","journal-title":"Am J Cardiol"},{"issue":"06","key":"ref54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7326\/M22-3238","article-title":"Risk for bleeding-related hospitalizations during use of amiodarone with apixaban or rivaroxaban in patients with atrial fibrillation : a retrospective cohort study","volume":"176","author":"W A Ray","year":"2023","journal-title":"Ann Intern Med"},{"issue":"02","key":"ref55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00045391-200403000-00003","article-title":"Use of ibutilide for cardioversion of recent-onset atrial fibrillation and flutter in elderly","volume":"11","author":"R M Gowda","year":"2004","journal-title":"Am J Ther"},{"issue":"09","key":"ref56","first-page":"CD005049","article-title":"Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation","volume":"9","author":"L Valembois","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"14","key":"ref57","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1056\/NEJMoa2019422","article-title":"Early rhythm-control therapy in patients with atrial fibrillation","volume":"383","author":"P Kirchhof","year":"2020","journal-title":"N Engl J Med"},{"issue":"11","key":"ref58","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1161\/CIRCULATIONAHA.122.060274","article-title":"Early rhythm control in patients with atrial fibrillation and high comorbidity burden","volume":"146","author":"A Rillig","year":"2022","journal-title":"Circulation"},{"issue":"05","key":"ref59","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/joa3.12608","article-title":"One-year follow-up results of the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry","volume":"37","author":"Y Guo","year":"2021","journal-title":"J Arrhythm"},{"issue":"06","key":"ref60","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/17474930211046743","article-title":"Oral anticoagulation improves survival in very elderly Chinese patients with atrial fibrillation: a report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry","volume":"17","author":"Y Guo","year":"2022","journal-title":"Int J Stroke"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211053140","article-title":"Are low doses of non-vitamin K antagonists effective in Chinese patients with atrial fibrillation? A report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry","author":"A Kotalczyk","year":"2021","journal-title":"Int J Stroke"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"f20","DOI":"10.1093\/ehjcvp\/pvz073","article-title":"Safety and efficacy of non-vitamin K antagonist oral anticoagulants in elderly patients with atrial fibrillation: systematic review and meta-analysis of 22 studies and 440\u2009281 patients","volume":"7","author":"A Silverio","year":"2021","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"06","key":"ref63","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.hrthm.2021.02.018","article-title":"Oral anticoagulants in extremely-high-risk, very elderly (>90 years) patients with atrial fibrillation","volume":"18","author":"T F Chao","year":"2021","journal-title":"Heart Rhythm"},{"issue":"08","key":"ref64","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/ehjcvp\/pvad058","article-title":"Clinical outcomes in elderly atrial fibrillation patients at increased bleeding risk treated with very low dose vs. regular-dose non-vitamin K antagonist oral anticoagulants: a nationwide cohort study","volume":"9","author":"Y H Chan","year":"2023","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"04","key":"ref65","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jacasi.2022.01.007","article-title":"Atrial fibrillation better care pathway adherent care improves outcomes in Chinese patients with atrial fibrillation","volume":"2","author":"Y Guo","year":"2022","journal-title":"JACC Asia"},{"issue":"25","key":"ref66","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1056\/NEJMoa1611594","article-title":"Prevention of bleeding in patients with atrial fibrillation undergoing PCI","volume":"375","author":"C M Gibson","year":"2016","journal-title":"N Engl J Med"},{"issue":"16","key":"ref67","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1708454","article-title":"Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation","volume":"377","author":"C P Cannon","year":"2017","journal-title":"N Engl J Med"},{"issue":"16","key":"ref68","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1817083","article-title":"Antithrombotic therapy after acute coronary syndrome or PCI in atrial fibrillation","volume":"380","author":"R D Lopes","year":"2019","journal-title":"N Engl J Med"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0140-6736(19)31872-0","article-title":"Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation (ENTRUST-AF PCI): a randomised, open-label, phase 3b trial","volume":"394","author":"P Vranckx","year":"2019","journal-title":"Lancet"},{"issue":"14","key":"ref70","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.jacc.2020.01.054","article-title":"Stent thrombosis with dual antithrombotic therapy in atrial fibrillation-ACS\/PCI trials","volume":"75","author":"M Galli","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"06","key":"ref71","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/CM9.0000000000001985","article-title":"Multimorbidity patterns and association with mortality in 0.5 million Chinese adults","volume":"135","author":"J Fan","year":"2022","journal-title":"Chin Med J (Engl)"},{"issue":"09","key":"ref72","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/europace\/euab079","article-title":"Characteristics and clinical outcomes in atrial fibrillation patients classified using cluster analysis: the Fushimi AF Registry","volume":"23","author":"H Ogawa","year":"2021","journal-title":"Europace"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"100784","DOI":"10.1016\/j.lanepe.2023.100784","article-title":"Atrial fibrillation: comorbidities, lifestyle, and patient factors","volume":"37","author":"E Shantsila","year":"2024","journal-title":"Lancet Reg Health Eur"},{"issue":"11","key":"ref74","doi-asserted-by":"crossref","first-page":"e015089","DOI":"10.1161\/JAHA.119.015089","article-title":"Polypharmacy, adverse outcomes, and treatment effectiveness in patients \u226575 with atrial fibrillation","volume":"9","author":"N Chen","year":"2020","journal-title":"J Am Heart Assoc"},{"issue":"05","key":"ref75","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00392-015-0936-y","article-title":"Polypharmacy and major adverse events in atrial fibrillation: observations from the AFFIRM trial","volume":"105","author":"M Proietti","year":"2016","journal-title":"Clin Res Cardiol"},{"issue":"09","key":"ref76","doi-asserted-by":"crossref","first-page":"e30107","DOI":"10.2196\/30107","article-title":"A web-based integrated management program for improving medication adherence and quality of life, and reducing readmission in patients with atrial fibrillation: randomized controlled trial","volume":"23","author":"H L Hsieh","year":"2021","journal-title":"J Med Internet Res"},{"issue":"04","key":"ref77","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/STROKEAHA.118.023877","article-title":"Cerebral ischemia in patients on direct oral anticoagulants","volume":"50","author":"K Macha","year":"2019","journal-title":"Stroke"},{"issue":"03","key":"ref78","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/2396987319841187","article-title":"Antithrombotic treatment for secondary prevention of stroke and other thromboembolic events in patients with stroke or transient ischemic attack and non-valvular atrial fibrillation: a European Stroke Organisation guideline","volume":"4","author":"C J Klijn","year":"2019","journal-title":"Eur Stroke J"},{"issue":"01","key":"ref79","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s12872-020-01766-w","article-title":"Elderly patients with atrial fibrillation in routine clinical practice-peri-procedural management of edoxaban oral anticoagulation therapy is associated with a low risk of bleeding and thromboembolic complications: a subset analysis of the prospective, observational, multinational EMIT-AF study","volume":"20","author":"M Unverdorben","year":"2020","journal-title":"BMC Cardiovasc Disord"},{"issue":"10","key":"ref80","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/europace\/euab065","article-title":"2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation","volume":"23","author":"J Steffel","year":"2021","journal-title":"Europace"},{"issue":"18","key":"ref81","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1161\/CIRCULATIONAHA.113.005754","article-title":"Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF)","volume":"129","author":"M W Sherwood","year":"2014","journal-title":"Circulation"},{"issue":"03","key":"ref82","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1160\/TH14-04-0305","article-title":"Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure. Substudy of the RE-LY trial","volume":"113","author":"J D Douketis","year":"2015","journal-title":"Thromb Haemost"},{"issue":"31","key":"ref83","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/eurheartj\/ehx403","article-title":"Predictors of pre-procedural concentrations of direct oral anticoagulants: a prospective multicentre study","volume":"38","author":"A Godier","year":"2017","journal-title":"Eur Heart J"},{"issue":"15","key":"ref84","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/bloodadvances.2020002335","article-title":"Predictors of preprocedural direct oral anticoagulant levels in patients having an elective surgery or procedure","volume":"4","author":"J R Shaw","year":"2020","journal-title":"Blood Adv"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejim.2018.04.018","article-title":"Frailty and atrial fibrillation: A systematic review","volume":"56","author":"E R Villani","year":"2018","journal-title":"Eur J Intern Med"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2325-5923.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T07:17:13Z","timestamp":1730791033000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2325-5923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":83,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,9,27]]},"published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2325-5923","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,14]]},"published":{"date-parts":[[2024,5,14]]}}}