{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:33:41Z","timestamp":1790876021648,"version":"4.1.0"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>\n            Objective\u2003The American College of Obstetricians and Gynecologists (ACOG) suggests expectant management until 34 weeks for patients with preterm premature rupture of membranes (PPROM). New data suggest extending to 37 weeks might enhance neonatal outcomes, reducing prematurity-linked issues. This study aims to assess adverse neonatal outcomes across gestational ages in women with PPROM.<\/jats:p><jats:p>\n            Study Design\u2003A retrospective cohort study was performed using linked vital statistics and the International Classification of Diseases, Ninth Revision data. Gestational age at delivery ranged from 32 to 36 weeks. Outcomes include neonatal intensive care unit (NICU) admission &gt;24\u2009hours, neonatal sepsis, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, and neonatal death. Multivariate regression analyses and chi-square tests were employed for statistical comparisons.<\/jats:p><jats:p>\n            Results\u2003In this cohort of 28,891 deliveries, there was a statistically significant decline in all studied adverse neonatal outcomes with increasing gestational age, without an increase in neonatal sepsis. At 32 weeks, 93% of newborns were in the NICU &gt;24\u2009hours compared with 81% at 34 weeks and 22% at 36 weeks (p\u2009&lt;\u20090.001). At 32 weeks, 20% had neonatal sepsis compared with 11% at 34 weeks and 3% at 36 weeks (p\u2009&lt;\u20090.001). At 32 weeks, 67% had respiratory distress syndrome compared with 44% at 34 weeks and 12% at 36 weeks (p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n            Conclusion\u2003In the setting of PPROM, later gestational age at delivery is associated with decreased rates of adverse neonatal outcomes without an increase in neonatal sepsis.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2328-6192","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T22:55:10Z","timestamp":1715900110000},"page":"2312-2314","source":"Crossref","is-referenced-by-count":6,"title":["Association between Gestational Age and Perinatal Outcomes in Women with Late Preterm Premature Rupture of Membranes"],"prefix":"10.1055","volume":"41","author":[{"given":"Eleanor M.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharti","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron B.","family":"Caughey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3390\/jcm11010214","article-title":"Expectant management of PPROM improves neonatal outcome-a retrospective study of 562 patients","volume":"11","author":"R E Bohil\u021bea","year":"2021","journal-title":"J Clin Med"},{"issue":"03","key":"ref2","first-page":"CD004735","article-title":"Planned early birth versus expectant management for women with preterm prelabour rupture of membranes prior to 37 weeks' gestation for improving pregnancy outcome","volume":"3","author":"D M Bond","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"9606","key":"ref3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"R L Goldenberg","year":"2008","journal-title":"Lancet"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1080\/14767058.2020.1731465","article-title":"The effects of latency period in PPROM cases managed expectantly","volume":"33","author":"E Baser","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1080\/14767058.2019.1651280","article-title":"Phenotypic overlap in neonatal respiratory morbidity following preterm premature rupture of membranes versus spontaneous preterm labor","volume":"34","author":"A Kachikis","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00431-021-04245-2","article-title":"Latency duration of preterm premature rupture of membranes and neonatal outcome: a retrospective single-center experience","volume":"181","author":"H M\u00fcller","year":"2022","journal-title":"Eur J Pediatr"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1515\/jpm-2019-0003","article-title":"The earlier the gestational age, the greater the intensity of the intra-amniotic inflammatory response in women with preterm premature rupture of membranes and amniotic fluid infection by Ureaplasma species","volume":"47","author":"K J Oh","year":"2019","journal-title":"J Perinat Med"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"558.e1","DOI":"10.1016\/j.ajog.2021.10.036","article-title":"Maternal morbidity after preterm premature rupture of membranes at <24 weeks' gestation","volume":"226","author":"A Sklar","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"09","key":"ref9","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.3390\/ijms24098027","article-title":"Biomarkers for pregnancy latency prediction after preterm premature rupture of membranes-a systematic review","volume":"24","author":"S Feduniw","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/OGX.0000000000001024","article-title":"Management of preterm premature rupture of membranes in the late preterm period","volume":"77","author":"S W Freeman","year":"2022","journal-title":"Obstet Gynecol Surv"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1080\/14767058.2020.1782377","article-title":"Preterm prelabor rupture of membranes: evaluating latency and neonatal morbidity for pregnancies with expectant management \u226534 weeks","volume":"35","author":"T A Lynch","year":"2022","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/01443615.2014.990432","article-title":"Conservative management of preterm premature rupture of membranes beyond 32 weeks' gestation: is it worthwhile?","volume":"35","author":"Z Tsafrir","year":"2015","journal-title":"J Obstet Gynaecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2328-6192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:27:06Z","timestamp":1730813226000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2328-6192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,16]]},"references-count":12,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2024,11,4]]},"published-print":{"date-parts":[[2024,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2328-6192","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,16]]},"published":{"date-parts":[[2024,5,16]]}}}