{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:42:50Z","timestamp":1781008970890,"version":"3.54.1"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Atypical sites for thrombosis include deep vein thrombosis (DVT) of the upper extremity (UE-DVT), splanchnic vein thrombosis (SVT), and cerebral venous sinus thrombosis (CVST). In addition to specific pathogenic factors, their underlying mechanisms share similarities with typical venous thromboembolism (VTE), namely, DVT of the lower extremity and\/or pulmonary embolism, but are less understood.<\/jats:p><jats:p>\n          Methods\u2003Records of unselected patients with a history of typical VTE (n\u2009=\u20092,011), UE-DVT (n\u2009=\u2009117), SVT (n\u2009=\u200983), and CVST (n\u2009=\u200982), who were referred to the Institute in Bonn for ambulatory thrombophilia testing, were retrospectively analyzed. Acquired and hereditary thrombosis risk factors were comparatively assessed.<\/jats:p><jats:p>\n          Results\u2003UE-DVT was characterized by a high rate (50.4%) of site-specific acquired risk factors. Compared with typical VTE, SVT was more frequently associated with systemic inflammation, infection, or malignancy (2.2 vs. 12.0%, p\u2009=\u20093\u00b710\u22128) and the JAK2\u2009V617F mutation was present in 16.9%. In CVST compared with typical VTE, demographics and higher rates of oral contraception (43.2 vs. 57.6%, p\u2009=\u20090.011) and pregnancy (4.2 vs. 10.9%, p\u2009=\u20090.012) suggest a significant hormonal influence on etiology. While the prevalence of inhibitor deficiencies and factor V Leiden mutation did not differ between cohorts, the prevalence of F2 20210G\u2009&gt;\u2009A was higher in SVT (15.7%, p\u2009=\u20090.003) and CVST (15.9%, p\u2009=\u20090.003) than in typical VTE (7.0%).<\/jats:p><jats:p>\n          Conclusion\u2003The cohorts with thrombosis in atypical sites showed distinctive patterns of acquired risk factors. Further studies are warranted to provide additional mechanistic insight into the role of hormonal influence in CVST and the contribution of F2 20210G\u2009&gt;\u2009A to the development of SVT and CVST.<\/jats:p>","DOI":"10.1055\/a-2329-1798","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T23:14:58Z","timestamp":1719443698000},"source":"Crossref","is-referenced-by-count":4,"title":["High Prevalence of F2 20210G\u2009&gt;\u2009A in Splanchnic Vein Thrombosis and Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study of Patients with Thrombosis in Atypical Sites"],"prefix":"10.1055","author":[{"given":"Dalia","family":"Khaddam","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"McRae","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"P\u00f6tzsch","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"R\u00fchl","sequence":"additional","affiliation":[{"name":"Institute of Experimental Hematology and 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