{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:13Z","timestamp":1740126853783,"version":"3.37.3"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective Spermatozoa are susceptible to oxidative radicals when\n                    antioxidant defenses are inadequate. The extent to which oxidative radicals\n                    contribute to sperm damage in patients with acromegaly remains unclear. This\n                    study aimed to investigate and elucidate this relationship.<\/jats:p><jats:p>\n          Methods The overall status of oxidants and antioxidants in both seminal\n                    plasma and serum of patients with acromegaly compared to a control group of\n                    healthy individuals was investigated. In addition, sperm parameters, including\n                    important measures such as growth hormone and insulin-like growth factor-1\n                    concentrations.<\/jats:p><jats:p>\n          Results Twenty-two patients with acromegaly with controlled disease and 14\n                    healthy controls were included. The total oxidant status was significantly\n                    higher in the semen samples of the patients with acromegaly. A negative\n                    correlation was found between sperm total oxidant status and total sperm count\n                    and sperm concentration. Similarly, a negative correlation was found between the\n                    total sperm count and the sperm oxidative stress index. In individuals diagnosed\n                    with acromegaly, there was a statistically significant increase in sperm growth\n                    hormone levels. Conversely, the level of insulin-like growth factor 1 was\n                    significantly increased in the sperm of the control group, which consisted of\n                    healthy individuals. The correlation analysis revealed a significant\n                    relationship between venous total oxidant status and growth hormone levels in\n                    semen.<\/jats:p><jats:p>\n          Conclusion The elevated levels of reactive oxygen radicals in individuals\n                    with acromegaly suggest a possible link between oxidative stress and its effects\n                    on semen quality.<\/jats:p>","DOI":"10.1055\/a-2329-2998","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T22:39:04Z","timestamp":1719614344000},"page":"498-506","source":"Crossref","is-referenced-by-count":0,"title":["The Association Between Oxidative Stress and Sperm Parameters in\n                    Patients with Acromegaly"],"prefix":"10.1055","volume":"132","author":[{"given":"Serdar","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Istanbul\n                    University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Cicek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Istanbul\n                    University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu Bet\u00fcl","family":"Kocaman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Istanbul\n                    University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Sulu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Istanbul\n                    University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande Mefkure","family":"Ozkaya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Istanbul\n                    University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdi","family":"Ozkara","sequence":"additional","affiliation":[{"name":"Department of Urology, Istanbul University-Cerrahpasa, Cerrahpasa\n                    School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dildar","family":"Konukoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Istanbul University-Cerrahpasa,\n                    Cerrahpasa School of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-140X","authenticated-orcid":false,"given":"Pinar","family":"Kadioglu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Istanbul\n                    University-Cerrahpasa, Cerrahpasa School of Medicine, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11102-023-01360-1","article-title":"Acromegaly Consensus Group. 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Agarwal","year":"2018","journal-title":"Andrologia"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.aju.2017.11.013","article-title":"Systematic review of antioxidant types and doses in male infertility: Benefits\n                    on semen parameters, advanced sperm function, assisted reproduction and\n                    live-birth rate","volume":"16","author":"A Majzoub","year":"2018","journal-title":"Arab J Urol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"S248","DOI":"10.4103\/2230-8210.84877","article-title":"Growth hormone in male infertility","volume":"15","author":"N Magon","year":"2011","journal-title":"Indian J Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1203\/00006450-198801000-00111","article-title":"Fertility and semen quality in previously growth hormone treated men","volume":"23","author":"S A Pedersen","year":"1988","journal-title":"Pediatr 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2329-2998.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:57:36Z","timestamp":1730807856000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2329-2998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":38,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2024,9,12]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2329-2998","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}