{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:21:22Z","timestamp":1740162082728,"version":"3.37.3"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection with murine typhus may be associated with significant morbidity. With nonspecific symptoms and laboratory abnormalities, diagnosis may be challenging. In this case, a pregnant patient presented with complaints of fevers and myalgias. Her laboratory results included severe transaminitis as well as thrombocytopenia and hyponatremia. She ultimately required vasopressor support and intensive care unit admission despite fluid resuscitation and broad-spectrum antibiotics. Empiric doxycycline was initiated due to suspicion for murine typhus, which laboratory testing later confirmed. Her clinical status improved with these interventions. This was a severe case of murine typhus resulting in septic shock and ischemic hepatitis. It is important to know the typical findings of murine typhus and consider it in a differential diagnosis, especially when practicing in endemic areas.<\/jats:p>","DOI":"10.1055\/a-2330-4249","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T22:44:11Z","timestamp":1716331451000},"page":"e185-e187","source":"Crossref","is-referenced-by-count":0,"title":["Ischemic Hepatitis and Septic Shock Secondary to Murine Typhus Infection in Pregnancy"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-489X","authenticated-orcid":false,"given":"Marissa","family":"Berry","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda M.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana F.","family":"Lahham","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis D.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, The University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actatropica.2016.10.018","article-title":"Clinical and laboratory characteristics, epidemiology, and outcomes of murine typhus: a systematic review","volume":"166","author":"C Tsioutis","year":"2017","journal-title":"Acta Trop"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.amjmed.2015.07.033","article-title":"The incidence and outcomes of ischemic hepatitis: a systematic review with meta-analysis","volume":"128","author":"E B Tapper","year":"2015","journal-title":"Am J Med"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/MOG.0000000000000355","article-title":"Current concepts in ischemic hepatitis","volume":"33","author":"J M Lightsey","year":"2017","journal-title":"Curr Opin Gastroenterol"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10620-011-1918-1","article-title":"Short and long-term outcomes in patients with acute liver failure due to ischemic hepatitis","volume":"57","author":"R M Taylor","year":"2012","journal-title":"Dig Dis Sci"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/cid\/ciy563","article-title":"A prospective, open-label, randomized trial of doxycycline versus azithromycin for the treatment of uncomplicated murine typhus","volume":"68","author":"P N Newton","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1517\/14740338.2016.1133584","article-title":"Revisiting doxycycline in pregnancy and early childhood: time to rebuild its reputation?","volume":"15","author":"R Cross","year":"2016","journal-title":"Expert Opin Drug Saf"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.cgh.2014.07.054","article-title":"Clinical and histologic features of azithromycin-induced liver injury","volume":"13","author":"M A Martinez","year":"2015","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["American Journal of Perinatology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2330-4249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T17:03:57Z","timestamp":1730826237000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2330-4249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":7,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2024,4,4]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2330-4249","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2157-6998","2157-7005"],"issn-type":[{"type":"print","value":"2157-6998"},{"type":"electronic","value":"2157-7005"}],"subject":[],"published-other":{"date-parts":[[2024,5,21]]},"published":{"date-parts":[[2024,4]]}}}