{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:19:22Z","timestamp":1780550362118,"version":"3.54.1"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2018R1D1A1B07045527"],"award-info":[{"award-number":["2018R1D1A1B07045527"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exercise-induced hypertension (EIH) is thought to be associated with increased\n                    cardiovascular (CV) risks. However, no previous studies have investigated the\n                    effects of EIH on CV systems in marathon runners without CV risk factors using\n                    both 24-hr ambulatory blood pressure (BP) monitoring and exercise stress\n                    echocardiography (ESE). This study firstly described differences in CV\n                    adaptations according to EIH assessed by both exams. Marathon runners between 35\n                    and 64 years of age without CV risk factors were eligible. All the participants\n                    underwent both 24-hr ambulatory BP monitoring and ESE. EIH was defined as a\n                    maximal exercise systolic BP\u2265210\u2009mmHg. The EIH group (n=19) had shorter training\n                    history and higher exercise intensity compared to the non-EIH group (n=23). The\n                    average systolic BP was higher in the EIH group than in the non-EIH group. Left\n                    cardiac chamber size and left ventricular mass (LVM) were also higher in the EIH\n                    group compared to the non-EIH group. Maximal BP during ESE was positively\n                    correlated with both parameters. Exaggerated BP response during exercise needs\n                    to be monitored for pre-emptive measurements before it results in progressive\n                    cardiovascular maladaptation.<\/jats:p>","DOI":"10.1055\/a-2330-9869","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T22:43:41Z","timestamp":1716331421000},"page":"930-936","source":"Crossref","is-referenced-by-count":7,"title":["Excessive Blood Pressure Rise and Cardiovascular Remodeling in\n                    Marathon Runners"],"prefix":"10.1055","volume":"45","author":[{"given":"Hye Bin","family":"Gwag","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung\n                    Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea\n                    (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9379-656X","authenticated-orcid":false,"given":"Young-Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of exercise rehabilitation & Welfare, Sungshin Women\u02bcs\n                    University, Seongbuk-gu, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Min","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular\n                    and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of\n                    Medicine, Seoul, Korea (the Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1161\/01.CIR.0000075572.40158.77","article-title":"Exercise and physical activity in the prevention and treatment of\n                    atherosclerotic cardiovascular disease: A statement from the Council on Clinical\n                    Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the\n                    Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on\n                    Physical Activity)","volume":"107","author":"P D Thompson","year":"2003","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jacc.2022.07.004","article-title":"Exercise for Primary and Secondary Prevention of Cardiovascular Disease: JACC\n                    Focus Seminar 1\/4","volume":"80","author":"W J Tucker","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/eurheartj\/ehn163","article-title":"Running: the risk of coronary events: Prevalence and prognostic relevance of\n                    coronary atherosclerosis in marathon runners","volume":"29","author":"S Mohlenkamp","year":"2008","journal-title":"Eur Heart J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/eurheartj\/ehn273","article-title":"The risk of marathon runners-live it up, run fast, die young?","volume":"29","author":"A Schmermund","year":"2008","journal-title":"Eur Heart J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jacc.2013.01.091","article-title":"Atrial fibrillation promotion by endurance exercise: Demonstration and\n                    mechanistic exploration in an animal model","volume":"62","author":"E Guasch","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e705","DOI":"10.1161\/CIR.0000000000000749","article-title":"Exercise-Related Acute Cardiovascular Events and Potential Deleterious\n                    Adaptations Following Long-Term Exercise Training: Placing the Risks Into\n                    Perspective-An Update: A Scientific Statement From the American Heart\n                    Association","volume":"141","author":"B A Franklin","year":"2020","journal-title":"Circulation"},{"key":"ref7","first-page":"355","article-title":"Training for Longevity: The Reverse J-Curve for Exercise","volume":"117","author":"E L O\u02bcKeefe","year":"2020","journal-title":"Mo Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1161\/01.CIR.101.3.336","article-title":"The athlete\u02bcs heart. A meta-analysis of cardiac structure and function","volume":"101","author":"B M Pluim","year":"2000","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jacc.2014.03.062","article-title":"Impact of lifelong exercise \"dose\" on left ventricular compliance and\n                    distensibility","volume":"64","author":"P S Bhella","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/CIRCULATIONAHA.114.008141","article-title":"Can intensive exercise harm the heart? You can get too much of a good thing","volume":"130","author":"A La Gerche","year":"2014","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00029.2014","article-title":"Are There Deleterious Cardiac Effects of Acute and Chronic Endurance\n                    Exercise?","volume":"96","author":"T M Eijsvogels","year":"2016","journal-title":"Physiol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fcvm.2018.00127","article-title":"Metabolic Mechanisms of Exercise-Induced Cardiac Remodeling","volume":"5","author":"K Fulghum","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e19911","DOI":"10.1097\/MD.0000000000019911","article-title":"Exercise-induced hypertension can increase the prevalence of coronary artery\n                    plaque among middle-aged male marathon runners","volume":"99","author":"C H Kim","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref14","first-page":"e11988","article-title":"Exercise-Induced Hypertension in Healthy Individuals and Athletes: Is it an\n                    Alarming Sign?","volume":"12","author":"LL M Mohammed","year":"2020","journal-title":"Cureus"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/0735-1097(95)00388-6","article-title":"Angiographic and prognostic implications of an exaggerated exercise systolic\n                    blood pressure response and rest systolic blood pressure in adults undergoing\n                    evaluation for suspected coronary artery disease","volume":"26","author":"M S Lauer","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euje.2005.12.014","article-title":"Recommendations for chamber quantification","volume":"7","author":"R M Lang","year":"2006","journal-title":"Eur J Echocardiogr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e20943","DOI":"10.1097\/MD.0000000000020943","article-title":"Exercise-induced hypertension is associated with angiotensin II activity and\n                    total nitric oxide","volume":"99","author":"C H Kim","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/jch.12629","article-title":"Exaggerated Exercise Blood Pressure Response and Future Cardiovascular\n                    Disease","volume":"17","author":"N Tzemos","year":"2015","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/ajh.2010.99","article-title":"Arterial stiffness and wave reflections in marathon runners","volume":"23","author":"C Vlachopoulos","year":"2010","journal-title":"Am J Hypertens"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cardiores.2005.04.032","article-title":"Molecular mechanisms of vascular adaptations to exercise. Physical activity as\n                    an effective antioxidant therapy?","volume":"67","author":"G Kojda","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tvjl.2015.10.036","article-title":"Modulation of acute transient exercise-induced hypertension after oral\n                    administration of four angiotensin-converting enzyme inhibitors in normotensive\n                    horses","volume":"208","author":"A Munoz","year":"2016","journal-title":"Vet J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/HYPERTENSIONAHA.118.11076","article-title":"Antihypertensive Treatment Fails to Control Blood Pressure During Exercise","volume":"72","author":"B Chant","year":"2018","journal-title":"Hypertension"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0735-1097(99)00048-0","article-title":"Losartan improves exercise tolerance in patients with 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Yoon","year":"2024","journal-title":"Int J Sports Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/hrt.2004.045245","article-title":"Carotid intima-media thickness in post-coarctectomy patients with exercise\n                    induced hypertension","volume":"91","author":"J W Vriend","year":"2005","journal-title":"Heart"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/CIRCRESAHA.121.318053","article-title":"Vascular Stress Signaling in Hypertension","volume":"128","author":"S M Cicalese","year":"2021","journal-title":"Circ Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jacc.2005.04.052","article-title":"Prevalence and clinical significance of left atrial remodeling in competitive\n                    athletes","volume":"46","author":"A Pelliccia","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1161\/CIRCULATIONAHA.118.037615","article-title":"Left Atrial Electromechanical Remodeling Following 2 Years of High-Intensity\n                    Exercise Training in Sedentary Middle-Aged Adults","volume":"139","author":"D A McNamara","year":"2019","journal-title":"Circulation"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3904\/kjim.2020.551","article-title":"The Korean Hypertension Cohort study: design and baseline characteristics","volume":"36","author":"H Y Lee","year":"2021","journal-title":"Korean J Intern Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/10641963.2013.789050","article-title":"Hypertensive response to exercise in dipper and non-dipper normotensive\n                    diabetics","volume":"36","author":"Z Kucukdurmaz","year":"2014","journal-title":"Clin Exp Hypertens"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/ajh\/hpw197","article-title":"Does Aerobic Exercise Increase 24-Hour Ambulatory Blood Pressure Among Workers\n                    With High Occupational Physical Activity?-A RCT","volume":"30","author":"M Korshoj","year":"2017","journal-title":"Am J Hypertens"}],"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2330-9869.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T01:17:11Z","timestamp":1737422231000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2330-9869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,11,4]]},"published-print":{"date-parts":[[2024,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2330-9869","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,21]]},"published":{"date-parts":[[2024,5,21]]}}}