{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:59:39Z","timestamp":1774490379827,"version":"3.50.1"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"07\/08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Migr\u00e4ne als h\u00e4ufige neurologische Erkrankung (10-15% der Bev\u00f6lkerung) ist mit\n                    zahlreichen Komorbidit\u00e4ten assoziiert, insbesondere mit anderen\n                    Schmerzsyndromen, psychischen Erkrankungen und funktionellen St\u00f6rungen. Diese\n                    \u201apsychosomatischen\u2018 Komorbidit\u00e4ten nehmen mit der Migr\u00e4neschwere weiter zu.\n                    Schwer betroffene, komorbide Patienten haben oft auch ein schlechteres\n                    Ansprechen auf die spezifische Migr\u00e4netherapie. Interessanterweise haben die\n                    Migr\u00e4ne und die genannten Komorbidit\u00e4ten zahlreiche gemeinsame \u00e4tiologische oder\n                    beg\u00fcnstigende Faktoren, z.B. genetische Faktoren, das h\u00e4ufigere Vorkommen bei\n                    Frauen und bei Menschen mit traumatischen Vorerfahrungen, sowie (bei\n                    Schmerzsyndromen) Zeichen einer zentralen Sensibilisierung. Eine weitere\n                    Gemeinsamkeit ist der Zusammenhang mit aktuellem oder chronischem Stresserleben.\n                    Wir schlagen ein erweitertes Diathese-Stress-Modell vor, das zusammenh\u00e4ngende,\n                    aber doch individuell unterschiedliche Vulnerabilit\u00e4ten ber\u00fccksichtigt und,\n                    abh\u00e4ngig vom Stresserleben, sowohl das Auftreten einzelner Erkrankungen (z.B.\n                    einer isolierten Migr\u00e4ne) als auch das gemeinsame Auftreten der Migr\u00e4ne mit\n                    anderen Schmerzsyndromen und weiteren psychosomatischen Komorbidit\u00e4ten abbilden\n                    kann. Zusammenfassend sollten psychosomatische Begleiterkrankungen in der\n                    Migr\u00e4netherapie stets im Blick behalten und ggf. fr\u00fchzeitig und multimodal\n                    behandelt werden.<\/jats:p>","DOI":"10.1055\/a-2331-0840","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T22:36:38Z","timestamp":1718663798000},"page":"304-309","source":"Crossref","is-referenced-by-count":2,"title":["Migr\u00e4ne und psychosomatische Komorbidit\u00e4ten"],"prefix":"10.1055","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-7158","authenticated-orcid":false,"given":"Ruth","family":"Ruscheweyh","sequence":"additional","affiliation":[{"name":"Neurologische Klinik und Poliklinik, Klinikum der Universit\u00e4t M\u00fcnchen,\n                    M\u00fcnchen, Germany"},{"name":"Klinik f\u00fcr Psychosomatische Medizin und Psychotherapie, Klinikum rechts\n                    der Isar der TUM, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Lehnen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychosomatische Medizin und Psychotherapie, Klinikum rechts\n                    der Isar der TUM, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Henningsen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Psychosomatische Medizin und Psychotherapie, Klinikum rechts\n                    der Isar der TUM, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s10194-021-01281-z","article-title":"Comorbidities of primary headache disorders: a literature review with\n                    meta-analysis","volume":"22","author":"V Caponnetto","year":"2021","journal-title":"J Headache Pain"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/0333102410373159","article-title":"Co-morbidity of migraine with somatic disease in a large population-based\n                    study","volume":"31","author":"H Le","year":"2011","journal-title":"Cephalalgia"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"T93","DOI":"10.1016\/j.jpain.2016.06.002","article-title":"Overlapping Chronic Pain Conditions: Implications for Diagnosis and\n                    Classification","volume":"17","author":"W Maixner","year":"2016","journal-title":"J Pain"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s10194-016-0649-2","article-title":"Headache, depression and anxiety: associations in the Eurolight project","volume":"17","author":"C Lampl","year":"2016","journal-title":"J Headache Pain"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/j.1526-4610.2009.01556.x","article-title":"Childhood maltreatment and migraine (part I). Prevalence and adult\n                    revictimization: a multicenter headache clinic survey","volume":"50","author":"G E Tietjen","year":"2010","journal-title":"Headache"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1111\/ene.15018","article-title":"International online survey of 1048 individuals with functional neurological\n                    disorder","volume":"28","author":"M Butler","year":"2021","journal-title":"Eur J Neurol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1093\/brain\/awq068","article-title":"The symptom of functional weakness: a controlled study of 107 patients","volume":"133","author":"J Stone","year":"2010","journal-title":"Brain"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.seizure.2015.12.006","article-title":"Patients with psychogenic nonepileptic seizures report more severe migraine than\n                    patients with epilepsy","volume":"34","author":"M A Shepard","year":"2016","journal-title":"Seizure"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/head.14213","article-title":"Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a\n                    common risk factor: A narrative review","volume":"61","author":"A Klein","year":"2021","journal-title":"Headache"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/head.14129","article-title":"Characterization of chronic overlapping pain conditions in patients with chronic\n                    migraine: A CHOIR study","volume":"61","author":"M J Barad","year":"2021","journal-title":"Headache"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1136\/jnnp.2009.192492","article-title":"Sociodemographic and comorbidity profiles of chronic migraine and episodic\n                    migraine sufferers","volume":"81","author":"D C Buse","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1111\/head.12195","article-title":"Correlation of headache frequency and psychosocial impairment in migraine: a\n                    cross-sectional study","volume":"54","author":"R Ruscheweyh","year":"2014","journal-title":"Headache"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1526-4610.2009.01557.x","article-title":"Childhood maltreatment and migraine (part II). Emotional abuse as a risk factor\n                    for headache chronification","volume":"50","author":"G E Tietjen","year":"2010","journal-title":"Headache"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/j.1468-2982.2008.01754.x","article-title":"Fibromyalgia comorbidity in primary headaches","volume":"29","author":"M de Tommaso","year":"2009","journal-title":"Cephalalgia"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1212\/WNL.0000000000004177","article-title":"Comorbid pain and migraine chronicity: The Chronic Migraine Epidemiology and\n                    Outcomes Study","volume":"89","author":"A I Scher","year":"2017","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/14728214.2023.2207819","article-title":"Emerging drugs for the preventive treatment of migraine: a review of CGRP\n                    monoclonal antibodies and gepants trials","volume":"28","author":"M Silvestro","year":"2023","journal-title":"Expert Opin Emerg Drugs"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s10194-023-01552-x","article-title":"Clinical evaluation of super-responders vs. non-responders to CGRP(-receptor)\n                    monoclonal antibodies: a real-world experience","volume":"24","author":"B Raffaelli","year":"2023","journal-title":"J Headache Pain"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3331024231174855","DOI":"10.1177\/03331024231174855","article-title":"What do patients\u2019 efficacy and tolerability ratings of acute migraine medication\n                    tell us? Cross-sectional data from the DMKG Headache Registry","volume":"43","author":"R Ruscheweyh","year":"2023","journal-title":"Cephalalgia"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.jpsychores.2010.01.010","article-title":"Latent class analysis of functional somatic symptoms in a population-based\n                    sample of twins","volume":"68","author":"K Kato","year":"2010","journal-title":"J Psychosom Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"eaap8757","DOI":"10.1126\/science.aap8757","article-title":"Analysis of shared heritability in common disorders of the brain","volume":"360","author":"Brainstorm Consortium","year":"2018","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s10194-019-0988-x","article-title":"Understanding the nature of psychiatric comorbidity in migraine: a systematic\n                    review focused on interactions and treatment implications","volume":"20","author":"T Dresler","year":"2019","journal-title":"J Headache Pain"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"s85","DOI":"10.11607\/ofph.2584","article-title":"Associations of Psychologic Factors with Multiple Chronic Overlapping Pain\n                    Conditions","volume":"34","author":"R B Fillingim","year":"2020","journal-title":"J Oral Facial Pain Headache"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s10194-017-0780-8","article-title":"Perceived stress in patients with migraine: a case-control study","volume":"18","author":"H-J Moon","year":"2017","journal-title":"J Headache Pain"},{"key":"ref24","doi-asserted-by":"crossref","DOI":"10.1026\/02851-000","volume-title":"Kognitiv-verhaltenstherapeutisches Migr\u00e4nemanagement (MIMA)","author":"T Klan","year":"2020"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.neuron.2012.01.001","article-title":"Understanding migraine through the lens of maladaptive stress responses: a model\n                    disease of allostatic load","volume":"73","author":"D Borsook","year":"2012","journal-title":"Neuron"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/PSY.0000000000000010","article-title":"Psychological trauma and functional somatic syndromes: a systematic review and\n                    meta-analysis","volume":"76","author":"N Afari","year":"2014","journal-title":"Psychosom Med"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1097\/01.j.pain.0000460343.46847.58","article-title":"Role of endogenous pain modulation in chronic pain mechanisms and treatment","volume":"156","author":"D Yarnitsky","year":"2015","journal-title":"Pain"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"831035","DOI":"10.3389\/fneur.2021.831035","article-title":"Cutaneous Allodynia in Migraine: A Narrative Review","volume":"12","author":"A M\u00ednguez-Olaondo","year":"2021","journal-title":"Front Neurol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1136\/practneurol-2020-002844","article-title":"Migraine: beyond pain","volume":"21","author":"N Karsan","year":"2021","journal-title":"Pract Neurol"},{"key":"ref30","first-page":"502","article-title":"Entspannungsverfahren und verhaltenstherapeutische Interventionen zur Behandlung\n                    der Migr\u00e4ne","volume":"6-7\/2016","author":"P Kropp","year":"2016","journal-title":"Nervenheilkunde"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1111\/head.14419","article-title":"Migraine in the context of chronic primary pain, chronic overlapping pain\n                    disorders, and functional somatic disorders: A narrative review","volume":"62","author":"P Henningsen","year":"2022","journal-title":"Headache"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/01.psy.0000075977.90337.e7","article-title":"Medically unexplained physical symptoms, anxiety, and depression: a\n                    meta-analytic review","volume":"65","author":"P Henningsen","year":"2003","journal-title":"Psychosom Med"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2331-0840.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T14:09:13Z","timestamp":1730815753000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2331-0840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,17]]},"references-count":32,"journal-issue":{"issue":"07\/08","published-online":{"date-parts":[[2024,7,18]]},"published-print":{"date-parts":[[2024,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2331-0840","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,17]]}}}