{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:23:45Z","timestamp":1768314225142,"version":"3.49.0"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Lurasidone (LUR) was compared with quetiapine extended\n                    release (QUE-ER) regarding 1-year discontinuation in patients with bipolar\n                    depression (n=317).<\/jats:p><jats:p>\n          Methods This is a retrospective cohort study.<\/jats:p><jats:p>\n          Results Although the time to all-cause discontinuation was estimated using\n                    the Kaplan\u2013Meier survival curve with log-rank tests to compare treatment groups,\n                    no difference was found (p=0.317). The Cox proportional hazard model revealed\n                    that only the presence of adverse events (AEs) is associated with increased\n                    treatment discontinuation (p&lt;0.0001). The most common AEs were akathisia for\n                    LUR (17.7%) and somnolence for QUE-ER (34.7%). In other Cox models divided by\n                    LUR or QUE-ER, the presence of akathisia or somnolence was associated with\n                    increased LUR (p=0.0205) or QUE-ER (p&lt;0.0001) discontinuation,\n                    respectively.<\/jats:p><jats:p>\n          Discussion The acceptability of both antipsychotics to bipolar depression\n                    in clinical practice may be similar. However, specific AEs for each\n                    antipsychotic (LUR: akathisia and QUE-ER: somnolence) were associated with high\n                    treatment discontinuation.<\/jats:p>","DOI":"10.1055\/a-2331-2300","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T23:05:37Z","timestamp":1718838337000},"page":"245-248","source":"Crossref","is-referenced-by-count":2,"title":["Discontinuation Rate of Lurasidone and Quetiapine Extended Release in\n                    Bipolar Depression"],"prefix":"10.1055","volume":"57","author":[{"given":"Taro","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine,\n                    Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine,\n                    Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Hamanaka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine,\n                    Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasufumi","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine,\n                    Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakao","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Fujita Health University School of Medicine,\n                    Toyoake, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1001\/jama.2023.18588","article-title":"Diagnosis 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trials","volume":"23","author":"T Kishi","year":"2021","journal-title":"Bipolar Disord"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJMoa051688","article-title":"Effectiveness of antipsychotic drugs in patients with chronic schizophrenia","volume":"353","author":"J A Lieberman","year":"2005","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1038\/s41380-021-01334-4","article-title":"Pharmacological treatment for bipolar mania: A systematic review and network\n                    meta-analysis of double-blind randomized controlled trials","volume":"27","author":"T Kishi","year":"2022","journal-title":"Mol Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/S2215-0366(23)00199-2","article-title":"Comparative efficacy and tolerability of pharmacological interventions for acute\n                    bipolar depression in adults: A systematic review and network meta-analysis","volume":"10","author":"A Yildiz","year":"2023","journal-title":"Lancet Psychiatry"},{"key":"ref7","volume-title":"Diagnostic and statistical manual of mental disorders, 5th ed","author":"APA","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.21037\/atm.2016.03.35","article-title":"Variable selection with stepwise and best subset approaches","volume":"4","author":"Z Zhang","year":"2016","journal-title":"Ann Transl Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.euroneuro.2023.03.015","article-title":"Antipsychotic-induced akathisia in adults with acute schizophrenia: A systematic\n                    review and dose-response meta-analysis","volume":"72","author":"H Wu","year":"2023","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"115833","DOI":"10.1016\/j.biopha.2023.115833","article-title":"The impacts of CYP3A4 genetic polymorphism and drug interactions on the\n                    metabolism of lurasidone","volume":"168","author":"Q Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/jpm12091362","article-title":"Racial\/ethnic differences in the pharmacokinetics of antipsychotics: focusing on\n                    East Asians","author":"S K Lin","year":"2022","journal-title":"J Pers Med"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/pcn.13137","article-title":"Double-blind, placebo-controlled study of lurasidone monotherapy for the\n                    treatment of bipolar I depression","volume":"74","author":"T Kato","year":"2020","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1007\/s00213-018-4977-6","article-title":"Multi-center, randomized, double-blind, placebo-controlled study of quetiapine\n                    extended-release formulation in Japanese patients with bipolar depression","volume":"235","author":"M Murasaki","year":"2018","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2331-2300.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:48:53Z","timestamp":1730810933000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2331-2300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,19]]},"references-count":13,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2024,9,3]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2331-2300","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,19]]}}}