{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:37:51Z","timestamp":1775169471516,"version":"3.50.1"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Epilepsy poses a significant global health challenge,\n                    particularly in regions with limited financial resources hindering access to\n                    treatment. Recent research highlights neuroinflammation, particularly involving\n                    cyclooxygenase-2 (COX-2) pathways, as a promising avenue for epilepsy\n                    management.<\/jats:p><jats:p>\n          Methods This study aimed to develop a Cyclooxygenase-2 inhibitor with\n                    potential anticonvulsant properties. A promising drug candidate was identified\n                    and chemically linked with phospholipids through docking analyses. The\n                    activation of this prodrug was assessed using phospholipase A2 (PLA2)-mediated\n                    hydrolysis studies. The conjugate\u02bcs confirmation and cytotoxicity were evaluated\n                    using Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning\n                    Calorimetry (DSC), and Sulphoramide B (SRB) assays.<\/jats:p><jats:p>\n          Results Docking studies revealed that the Celecoxib-Phospholipid conjugate\n                    exhibited a superior affinity for PLA2 compared to other drug-phospholipid\n                    conjugates. FT-IR spectroscopy confirmed the successful synthesis of the\n                    conjugate, while DSC analysis confirmed its purity and formation. PLA2-mediated\n                    hydrolysis experiments demonstrated selective activation of the prodrug\n                    depending on PLA2 concentration. SRB experiments indicated dose-dependent\n                    cytotoxic effects of Celecoxib, phospholipid non-toxicity, and efficient\n                    celecoxib-phospholipid conjugation.<\/jats:p><jats:p>\n          Conclusion This study successfully developed a Celecoxib-phospholipid\n                    conjugate with potential anticonvulsant properties. The prodrug\u02bcs specific\n                    activation and cytotoxicity profile makes it a promising therapeutic candidate.\n                    Further investigation into underlying mechanisms and in vivo studies is\n                    necessary to assess its translational potential fully.<\/jats:p>","DOI":"10.1055\/a-2331-7114","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T23:29:25Z","timestamp":1720222165000},"page":"296-301","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Anticonvulsant Properties of a Celecoxib-Phospholipid\n                    Conjugate: Synthesis, Activation, and Evaluation of Cytotoxicity"],"prefix":"10.1055","volume":"74","author":[{"given":"Puthusserikkunnu B","family":"Anjali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of\n                    Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natarajan","family":"Jawahar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of\n                    Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandadhi R","family":"Praharsh Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of\n                    Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selvaraj","family":"Jubie","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS\n                    Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramanian","family":"Selvamuthukumar","sequence":"additional","affiliation":[{"name":"Deparment of Pharmacy, Annamalai University, Annamalai Nagar,\n                    Chidambaram, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.18203\/2319-2003.ijbcp20162454","article-title":"Evaluation of anticonvulsant effect of celecoxib, a selective cyclooxygenase-2\n                    inhibitor in experimentally induced convulsions in albino rats","volume":"5","author":"M N Nadeem","year":"2016","journal-title":"Int J Basic Clin Pharmacol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"102470","DOI":"10.1016\/j.jddst.2021.102470","article-title":"Preparation, physicochemical and biopharmaceutical characterization of\n                    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