{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:03:48Z","timestamp":1791979428341,"version":"4.4.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background Endoscopic ultrasound (EUS)-guided drainage of walled-off necrosis (WON) using either plastic or metal stents is the mainstay of WON management. Our single-center randomized controlled trial aimed to evaluate the efficacy of biflanged metal stents (BFMSs) and plastic stents for WON drainage.<\/jats:p><jats:p>\n            Methods Patients with symptomatic WON amenable to EUS-guided drainage were randomized to receive either BFMSs or plastic stents. The primary outcome was reintervention-free clinical success at 4 weeks. Secondary outcomes were: overall clinical success (complete resolution of symptoms and significant reduction in size of WON [&lt;50% of original size and &lt;5 cm in largest diameter at 4-week follow-up]); number of reinterventions; adverse events (AEs); hospital stay for first admission; and medium-term outcomes at 6 months (recurrence, disconnected pancreatic duct, chronic pancreatitis, and new-onset diabetes mellitus).<\/jats:p><jats:p>\n            Results 92 patients were randomized: 46 in each arm. The reintervention-free clinical success rate was significantly higher in the BFMS group on intention-to-treat analysis (67.4% vs. 43.5%; P = 0.02). Overall clinical success at 1 month was similar in both groups. There were significantly fewer reinterventions (median 0 [IQR 0\u20131] vs. 1 [0\u20132]; P = 0.03) and shorter hospital stays in the BFMS group (7.0 [SD 3.4] vs. 9.1 [5.5] days; P = 0.04). There were no differences in procedure-related AEs, mortality, or medium-term outcomes.<\/jats:p><jats:p>\n            Conclusions BFMSs provide better reintervention-free clinical success at 4 weeks, with shorter hospital stay and without increased risks of AEs, compared with plastic stents for EUS-guided drainage of WON. Medium-term outcomes are however similar for both stent types.<\/jats:p>","DOI":"10.1055\/a-2332-3448","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T22:56:50Z","timestamp":1716505010000},"page":"915-923","source":"Crossref","is-referenced-by-count":15,"title":["Biflanged metal stents versus plastic stents for endoscopic ultrasound-guided drainage of walled-off necrosis: a randomized controlled trial"],"prefix":"10.1055","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct04479228","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Krithi Krishna","family":"Koduri","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-0164","authenticated-orcid":false,"given":"Nitin","family":"Jagtap","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-9209","authenticated-orcid":false,"given":"Sundeep","family":"Lakhtakia","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-6228","authenticated-orcid":false,"given":"Basha","family":"Jahangeer","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-779X","authenticated-orcid":false,"given":"Shujaath","family":"Asif","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupjyoti","family":"Talukdar","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guru","family":"Trikudanathan","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition, University of Minnesota Twin Cities, Minneapolis, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Tandan","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kalapala","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-4781","authenticated-orcid":false,"given":"Zaheer","family":"Nabi","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Ramchandani","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadish","family":"Singh","sequence":"additional","affiliation":[{"name":"Radiodiagnosis and Interventional Radiology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana Fatima","family":"Memon","sequence":"additional","affiliation":[{"name":"Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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