{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:21:03Z","timestamp":1783477263437,"version":"3.55.0"},"reference-count":75,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"name":"Eva Luise und Horst K\u00f6hler Stiftung & Else Kr\u00f6ner-Fresenius-Stiftung","award":["2019_KollegSE.03"],"award-info":[{"award-number":["2019_KollegSE.03"]}]},{"name":"F\u00f6rderprogramm f\u00fcr Forschung und Lehre","award":["1169"],"award-info":[{"award-number":["1169"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["314061271-TRR205 ,325768017"],"award-info":[{"award-number":["314061271-TRR205 ,325768017"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperandrogenemia in patients with Cushing\u2019s syndrome (CS) presents a diagnostic\n                    pitfall due to its rare occurrence and overlapping symptoms with more common\n                    conditions like polycystic ovary syndrome (PCOS). This review explores the\n                    significance of androgen dysregulation in CS, focusing on both classical and\n                    11-oxygenated androgens. While classical androgens contribute to\n                    hyperandrogenism in CS, their levels alone do not fully account for clinical\n                    symptoms. Recent research highlights the overlooked role of 11oxC19 androgens,\n                    particularly 11OHA4 and 11KT, in driving hyperandrogenic manifestations across\n                    all CS subtypes. These adrenal-specific and highly potent androgens offer stable\n                    expression throughout the lifespan of a woman, serving as valuable diagnostic\n                    biomarkers. Understanding their prominence not only aids in subtype\n                    differentiation but also provides insights into the complex nature of androgen\n                    dysregulation in CS. Recognizing the diagnostic potential of 11oxC19 androgens\n                    promises to refine diagnostic approaches and improve clinical management\n                    strategies for patients with CS.<\/jats:p>","DOI":"10.1055\/a-2333-1907","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T23:11:25Z","timestamp":1716592285000},"page":"670-677","source":"Crossref","is-referenced-by-count":4,"title":["The Landscape of Androgens in Cushing\u2019s Syndrome"],"prefix":"10.1055","volume":"132","author":[{"given":"Hanna F.","family":"Nowotny","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, LMU University Hospital, LMU\n                    Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, LMU University Hospital, LMU\n                    Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Reisch","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, LMU University Hospital, LMU\n                    Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s40618-022-01754-1","article-title":"Global Cushing's disease epidemiology: A systematic review and\n                    meta-analysis of observational studies","volume":"45","author":"G Giuffrida","year":"2022","journal-title":"J Endocrinol Invest"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing's syndrome","volume":"367","author":"J Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ecl.2007.10.010","article-title":"Cushing's Syndrome","volume":"37","author":"R Pivonello","year":"2008","journal-title":"Endocrinol Metab Clin North Am"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S0140-6736(14)61375-1","article-title":"Cushing's syndrome","volume":"386","author":"A Lacroix","year":"2015","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"766","DOI":"10.3389\/fendo.2019.00766","article-title":"Toward a diagnostic score in Cushing's syndrome","volume":"10","author":"L T Braun","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1530\/EJE-11-1095","article-title":"The burden of Cushing's disease: Clinical and health-related quality of\n                    life aspects","volume":"167","author":"R A Feelders","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1530\/EJE-11-0272","article-title":"The European Registry on Cushing's syndrome: 2-year experience. 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