{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:12:21Z","timestamp":1776852741430,"version":"3.51.2"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Duodenal atresia (DA) is the most common atresia of the small bowel. This study aims to assess the prevalence, mortality, and associated anomalies related to DA in Finland from 2004 to 2017.<\/jats:p><jats:p>\n          Material and Methods\u2003A nationwide study based on registers maintained by the Finnish Institute for Health and Welfare and Statistics Finland containing data on all live births and stillbirths and terminations of pregnancy. The cases were identified based on the ICD-9 and 10 (International Classification of Diseases revisions 9 and 10) codes. Associated anomalies were classified based on the EUROCAT criteria; minor anomalies were excluded.<\/jats:p><jats:p>\n          Results\u2003There were 249 DA cases including 222 (89.2%) live births, 16 (6.4%) stillbirths, and 11 (4.4%) terminations. There was no significant change in the prevalence rates between 2004 and 2017. Live birth prevalence was 2.75\/10,000 and total prevalence was 3.08\/10,000 births. A total of 100 (40.2%) cases were isolated, 67 (26.9%) had other multiple congenital anomalies, and 83 (33.3%) were syndromic. There were no terminations in isolated DA. Most associated anomalies were cardiac (36.1%), followed by other gastrointestinal tract anomalies (23.7%) and limb deformities\/defects (7.2%). Trisomy 21 was observed in 63 cases (25.3%). Neonatal mortality was 3.6% (n\u2009=\u20098) and at 1 year 95.0% were alive. Both neonatal and infant mortalities were associated with cardiac anomalies (p\u2009&lt;\u20090.001 and p\u2009=\u20090.001, respectively). All neonatal deaths had associated cardiac defect(s).<\/jats:p><jats:p>\n          Conclusions\u2003The prevalence of DA in Finland remains stable and among the highest reported. DA is often associated with cardiac anomalies, which portend a high risk for mortality. Despite the burden of associated anomalies, overall survival is high.<\/jats:p>","DOI":"10.1055\/a-2338-5873","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T23:06:22Z","timestamp":1717628782000},"page":"544-549","source":"Crossref","is-referenced-by-count":2,"title":["Duodenal Atresia in Finland from 2004 to 2017: Prevalence, Mortality, and Associated Anomalies\u2014A Population-Based Study"],"prefix":"10.1055","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-963X","authenticated-orcid":false,"given":"Suvi","family":"Alik\u00e4rri","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Orthopaedics and Traumatology, University of Turku and Turku University Hospital, Turku, Finland"},{"name":"Department of Surgery, Kanta-H\u00e4me Central Hospital, H\u00e4meenlinna, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkka","family":"Helenius","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Orthopaedics and Traumatology, University of Turku and Turku University Hospital, Turku, Finland"},{"name":"Department of Orthopaedics and Traumatology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Heiskanen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Orthopaedics and Traumatology, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Syv\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery, Orthopaedics and Traumatology, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teemu","family":"Kemppainen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliisa","family":"L\u00f6yttyniemi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Turku and Turku University Hospital, Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Knowledge Brokers, Finnish Institute of Health and Welfare, Helsinki, Finland"},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden and Academic Primary Health Care Centre, Region Stockholm, Stockholm, 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