{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T04:15:11Z","timestamp":1742876111093,"version":"3.40.2"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Abdominal adhesions following surgery can lead to complications like intestinal obstruction and pelvic pain. While no molecular therapies currently target the underlying adhesion formation process, various barrier agents exist. 4DryField\u00ae has shown promise in reducing bleeding and adhesions in adults. This study aimed to assess its effectiveness in children.<\/jats:p><jats:p>\n          Methods\u2003The study examined all pediatric patients who underwent laparotomy between January 2018 and February 2022. It compared outcomes between those treated with 4DryField\u00ae and a control group. Key endpoints included surgical revision, adhesion recurrence, infections, insufficiencies, fever, C-reactive protein (CRP) levels, and time to gastrointestinal passage.<\/jats:p><jats:p>\n          Results\u2003In total, 233 children had surgery for bowel adhesions. After propensity score matching, 82 patients were included in the analysis: 39 in the control and 43 in the 4DryField\u00ae group. 4DryField\u00ae did not affect the readhesion rate. Children in the treatment group had significantly more complications (47 vs. 15%, p\u2009=\u20090.002), more often fever, and higher CRP levels.<\/jats:p><jats:p>\n          Conclusions\u20034DryField\u00ae did not show potential in reducing adhesion formation, but it was associated with significantly more complications in pediatric patients. Thus, future prospective studies are needed to evaluate the safety and effectiveness of 4DryField\u00ae in children.<\/jats:p>","DOI":"10.1055\/a-2340-9373","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T23:04:12Z","timestamp":1717801452000},"page":"159-164","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of 4DryField\u00ae as an Adhesion Prophylaxis in Pediatric Patients: A Propensity-Score Matched Study"],"prefix":"10.1055","volume":"35","author":[{"given":"Michaela","family":"Klinke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Dietze","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Trautmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marietta","family":"Jank","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Martel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Elrod","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Boettcher","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Medical Centre Mannheim, Mannheim, Baden-W\u00fcrttemberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"f5588","DOI":"10.1136\/bmj.f5588","article-title":"Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis","volume":"347","author":"R PG ten Broek","year":"2013","journal-title":"BMJ"},{"issue":"232","key":"ref2","first-page":"52","article-title":"Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intra-abdominal adhesions","author":"F R Dijkstra","year":"2000","journal-title":"Scand J Gastroenterol Suppl"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jpedsurg.2005.05.015","article-title":"Efficacy of Seprafilm for reducing reoperative risk in pediatric surgical patients undergoing abdominal surgery","volume":"40","author":"M Inoue","year":"2005","journal-title":"J Pediatr Surg"},{"key":"ref4","first-page":"27","article-title":"Peritoneal adhesions. 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