{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T05:29:50Z","timestamp":1735709390599,"version":"3.32.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n            Objective\u2003Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. Current expanded treatment recommendations result in the inclusion of a large percentage of the obstetric population, which has limited their adoption. The purpose of this study was to identify a population at high risk for VTE, with minimal impact on the number of patients that would qualify for expanded treatment.<\/jats:p><jats:p>\n            Study Design\u2003We performed a retrospective analysis of a large obstetric population. International Classification of Diseases, 10th Revsion (ICD-10) codes for VTE were used to identify patients presenting for obstetric or postpartum (PP) care from January 2016 to March 2018. The review focused on high-risk factors (history of VTE or high-risk thrombophilia), antepartum hospital admissions that were &gt;72\u2009hours in the previous 30 days, use of sequential compression devices, body mass index (BMI; kg\/m2), age, and mode of delivery. Pharmacologic treatment efficacy was set at 90, 75, or 50%.<\/jats:p><jats:p>\n            Results\u2003During the 27-month review period, there were 120,235 deliveries and 93 had a VTE event in the index pregnancy or within 4 weeks PP (7.7\/10,000 births). A history of VTE or high-risk thrombophilia was seen in 25.8% of cases. Antepartum admission was noted in 40.9%, and the combination of cesarean delivery (CD) with age and BMI \u226535 (Age\u2009+\u2009BMI\u2009+\u2009CD) was noted in 17.3% of PP cases. Targeting these latter two groups for VTE prophylaxis with a 75% efficacy suggests that 34% of the VTE events would likely have been prevented while increasing the total population treated by approximately 2%.<\/jats:p><jats:p>\n            Conclusion\u2003Expanding pharmacologic prophylactical coverage to include an antepartum admission of &gt;72\u2009hours and those with Age\u2009+\u2009BMI\u2009+\u2009CD would result in about a one-third reduction in total VTE events with about 2% requiring treatment. These data support some of the suggested recommendations for expanded pharmacological deep venous thrombosis prophylaxis.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2342-0919","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:18:56Z","timestamp":1718061536000},"page":"231-237","source":"Crossref","is-referenced-by-count":0,"title":["Venous Thromboembolism Prophylaxis Should Be Recommended for Antepartum Admissions and Cesarean Delivery if Age and Body Mass Index Are Greater Than 35"],"prefix":"10.1055","volume":"42","author":[{"given":"Laurence E.","family":"Shields","sequence":"additional","affiliation":[{"name":"Marian Regional Medical Center, Santa Maria, California"},{"name":"CommonSpirit Health, Women and Infants Clinical Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Feldman","sequence":"additional","affiliation":[{"name":"Marian Regional Medical Center, Santa Maria, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Klein","sequence":"additional","affiliation":[{"name":"CommonSpirit Health, Women and Infants Clinical Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy","family":"Foster","sequence":"additional","affiliation":[{"name":"CommonSpirit Health, Women and Infants Clinical Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Lin","sequence":"additional","affiliation":[{"name":"Marian Regional Medical Center, Santa Maria, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AOG.0000000000002706","article-title":"ACOG Practice Bulletin No. 196: Thromboembolism in pregnancy","volume":"132","author":"American College of Obstetricians and 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at risk during pregnancy and the early postnatal period","volume":"3","author":"P Middleton","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"issue":"04","key":"ref15","first-page":"530","article-title":"Evaluation of a risk-stratified, heparin-based, obstetric thromboprophylaxis protocol","volume":"138","author":"M Y Lu","year":"2021","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1213\/ANE.0000000000001569","article-title":"National Partnership for Maternal Safety: Consensus bundle on venous thromboembolism","volume":"123","author":"M E D'Alton","year":"2016","journal-title":"Anesth Analg"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1097\/CCM.0b013e31828cf104","article-title":"Heparin thromboprophylaxis in medical-surgical critically ill patients: a systematic review and meta-analysis of randomized trials","volume":"41","author":"W 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Greenall","year":"2020","journal-title":"BMJ Open"}],"container-title":["American Journal of 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