{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:31:42Z","timestamp":1787164302922,"version":"build-2736575974"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Enteroviruses (EV) are most common causes of the etiologically\n                    known aseptic meningitis in children. EV can be detected with polymerase chain\n                    reaction (PCR) in cerebrospinal fluid (CSF) samples. We aimed to evaluate the\n                    clinical and laboratory characteristics of children diagnosed with PCR-confirmed\n                    EV meningitis in CSF samples.<\/jats:p>\n                  <jats:p>Patients Patients aged 1 month to 17 years who underwent lumbar puncture\n                    (LP) with suspected meningitis and had CSF viral PCR and culture results between\n                    September 2012 and January 2021 at a tertiary care hospital in Turkey were\n                    included.<\/jats:p>\n                  <jats:p>Methods Patients with no virus detected in CSF samples by PCR was\n                    comprised PCR-negative group. The EV PCR-positive patients were divided into two\n                    groups based on CSF pleocytosis as enteroviral meningitis (EVM) with CSF\n                    pleocytosis and EVM without CSF pleocytosis, and compared in terms of clinical\n                    and laboratory features.<\/jats:p>\n                  <jats:p>Results 78 (38.2%) were EV PCR-positive, and 126 (61.8%) were\n                    PCR-negative. Pleocytosis was detected in 55 (70.5%) EV PCR-positive patients\n                    and 94 (74.6%) of PCR-negative patients. Convulsion was significantly frequent\n                    (p=0.017) in EV PCR-positive patients with no pleocytosis. Protein and lactate\n                    concentrations in CSF were significantly higher in EV PCR-positive patients with\n                    pleocytosis (p=0.048, p=0.001, respectively). Median hospital stay was\n                    significantly longer in PCR-negative group (p&lt;0.001).<\/jats:p>\n                  <jats:p>Conclusion Diagnosing EVM with PCR prevents long-term hospitalization,\n                    unnecessary antibiotic use and healthcare-related complications.<\/jats:p>","DOI":"10.1055\/a-2345-3186","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T19:07:09Z","timestamp":1722625629000},"page":"227-234","source":"Crossref","is-referenced-by-count":2,"title":["Enteroviral meningitis in children: Clinical and laboratory features\n                    with and without pleocytosis"],"prefix":"10.1055","volume":"237","author":[{"given":"Zeynep Sava\u015f","family":"\u015een","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Ozdem","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Mersin \u015eehir E\u011fitim ve Ara\u015ft\u0131rma\n                    Hastanesi, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0083-0587","authenticated-orcid":false,"given":"Rumeysa","family":"Yalcinkaya","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruveyda","family":"Gumuser Cinni","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Polat","sequence":"additional","affiliation":[{"name":"Pediatrics, Dr Sami Ulus Gynecology Obstetrics and Child Health and\n                    Diseases Training and Research Hospital, \u00c7ankaya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Polat","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, Gazi University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Kaman","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turkan","family":"Ayd\u0131n Teke","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonul","family":"Tanir","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease, SBU Ankara Dr Sami Ulus Maternity Child\n                    Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nur","family":"\u00d6z","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Ankara Etlik Integrated Health Campus,\n                    Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref1","first-page":"e19955","article-title":"Enteroviral Meningitis in Neonates and Children of Mashhad, Iran","volume":"9","author":"MJ G Shahroodi","year":"2016","journal-title":"Jundishapur J Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/infdis\/168.4.888","article-title":"Aseptic meningitis in infants<2 years of age: diagnosis and etiology","volume":"168","author":"L E Berlin","year":"1993","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1086\/422650","article-title":"Multiple-year experience in the diagnosis of viral central nervous system\n                    infections with a panel of polymerase chain reaction assays for detection of 11\n                    viruses","volume":"39","author":"C Huang","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00006454-200204000-00005","article-title":"Impact of rapid polymerase chain reaction results on management of pediatric\n                    patients with enteroviral meningitis","volume":"21","author":"C C Robinson","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"ref5","first-page":"309.","volume-title":"Bacterial meningitis beyond the neonatal period. 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