{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:30Z","timestamp":1740126810621,"version":"3.37.3"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["U01 HD36790,U10 HD21364,U10 HD21373,U10 HD21385,U10 HD21397,U10 HD21415,U10 HD27851,U10 HD27853,U10 HD27856,U10 HD27871,U10 HD27880,U10 HD27881,U10 HD27904,U10 HD34216,U10 HD40461,U10 HD40492,U10 HD40498,U10 HD40689"],"award-info":[{"award-number":["U01 HD36790,U10 HD21364,U10 HD21373,U10 HD21385,U10 HD21397,U10 HD21415,U10 HD27851,U10 HD27853,U10 HD27856,U10 HD27871,U10 HD27880,U10 HD27881,U10 HD27904,U10 HD34216,U10 HD40461,U10 HD40492,U10 HD40498,U10 HD40689"]}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"crossref","award":["U01 HG4423"],"award-info":[{"award-number":["U01 HG4423"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["M01 RR16587,M01 RR30,M01 RR32,M01 RR39,M01 RR6022,M01 RR633,M01 RR70,M01 RR7122,M01 RR750,M01 RR80,M01 RR8084,M01 RR997"],"award-info":[{"award-number":["M01 RR16587,M01 RR30,M01 RR32,M01 RR39,M01 RR6022,M01 RR633,M01 RR70,M01 RR7122,M01 RR750,M01 RR80,M01 RR8084,M01 RR997"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["U01 HL094338 ,U01 HL094355"],"award-info":[{"award-number":["U01 HL094338 ,U01 HL094355"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n            Objective\u2003Extremely preterm infants are at high risk of neonatal mortality and morbidity. Extreme preterm birth (PTB) may result from spontaneous preterm labor or preterm premature rupture of membranes or may be indicated due to preeclampsia, eclampsia, hypertension, or other causes. Our objective was to identify single nucleotide polymorphisms (SNPs) and biological pathways associated with spontaneous versus indicated extreme PTB using the neonatal genome.<\/jats:p><jats:p>\n            Study Design\u2003We evaluated 523 spontaneous births and 134 indicated births weighing 401 to 1,000\u2009g at birth from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Genomics dataset by genome-wide association study (GWAS) and pathway analysis. The TOLSURF cohort was used to replicate the results.<\/jats:p><jats:p>\n            Results\u2003In the NRN GWAS, no statistically significant results were found, although the Manhattan plot showed one almost significant peak (rs60854043 on chromosome 14 at p\u2009=\u20091.03E-07) along with many other modest peaks at p\u2009=\u20091\u20139E-06, for a total of 15 suggestive associations at this locus. In the NRN pathway analysis, multiple pathways were identified, with the most significant being \u201cGO_mf:go_low_density_lipoprotein_particle_receptor_activity\u201d at p\u2009=\u20091.14E-06. However, these results could not be replicated in the TOLSURF cohort.<\/jats:p><jats:p>\n            Conclusion\u2003Genomic differences are seen between infants born by spontaneous versus indicated extreme PTB. Due to the limited sample size, there is a need for larger studies.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2347-3751","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T23:15:53Z","timestamp":1718752553000},"page":"238-249","source":"Crossref","is-referenced-by-count":0,"title":["Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-9092","authenticated-orcid":false,"given":"Namasivayam","family":"Ambalavanan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Michael","family":"Cotten","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Genomics Research Center, RTI International, Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Mathur","sequence":"additional","affiliation":[{"name":"Genomics Research Center, RTI International, Research Triangle Park, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dara","family":"Torgerson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L.","family":"Ballard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Francisco, San Francisco, California"},{"name":"National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Eunice Kennedy Shriver NICHD Neonatal Research Network and the TOLSURF Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis","volume":"7","author":"S Chawanpaiboon","year":"2019","journal-title":"Lancet Glob Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of 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