{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:34:16Z","timestamp":1784306056132,"version":"3.55.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background In amyotrophic lateral sclerosis (ALS) prognosis is poor due to progressive weakening of the respiratory muscles. Survival and quality of life can be improved by noninvasive ventilation (NIV), which is initially applied while sleeping. The indication for NIV is based on pulmonary function testing (PFT) and polysomnography (PSG) with capnography (tCO2). While it is desirable to predict nocturnal ventilation by waking PFT in ALS, the parameters suited for reliable predictions remain elusive.\n    <\/jats:p><jats:p>\n            Methods We retrospectively analyzed parameters derived from PFT (spirometry, body plethysmography, diffusion capacity, respiratory muscle testing) and blood gas analysis, PSG and tCO2 in 42 patients with ALS (27 men, 15 women, age 69 \u00b1 12.1 years) and performed Spearman\u2019s correlation analysis of daytime waking parameters and nighttime sleep parameters.\n    <\/jats:p><jats:p>\n            Results 28 patients (66.7%) showed restrictive impairment of ventilation and 15 patients (48.3%) showed insufficiency of the respiratory musculature. There was no obstructive impairment of ventilation. We did not observe any significant correlations between any single daytime PFT parameter with nocturnal pCO2. However, there were significant correlations between the ratios PIF\/PEF, MEF50\/MIF50, DLCO\/VA as well as FEV1\/FVC and nocturnal pCO2. Highly normal FEV1\/FVC and Krogh-Factor (DLCOc\/VA) indicated nocturnal hypercapnia. Furthermore, waking hypercapnia, concentrations of bicarbonate and base excess were each positively correlated with nocturnal hypercapnia.\n    <\/jats:p><jats:p>\n            Conclusions Waking PFT is not a good predictor of nocturnal ventilation. Inspiratory parameters as well as the ratios FEV1\/FVC and DLCO\/VA performed best and should be included in the interpretation. Our analyses confirm the relevance of inspiratory muscle weakness in ALS. PSG and tCO2 remain the gold standard for the assessment of nocturnal ventilation.\n    <\/jats:p>","DOI":"10.1055\/a-2349-0936","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T23:33:31Z","timestamp":1722382411000},"page":"626-633","source":"Crossref","is-referenced-by-count":3,"title":["Prediction of nocturnal ventilation by pulmonary function testing in patients with amyotrophic lateral sclerosis"],"prefix":"10.1055","volume":"78","author":[{"given":"Friederike","family":"Tress","sequence":"additional","affiliation":[{"name":"Pneumonology, Otto von Guericke University Magdeburg Medical Faculty, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Luecke","sequence":"additional","affiliation":[{"name":"Pneumonology, Otto von Guericke University Magdeburg Medical Faculty, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Stegemann-Koniszewski","sequence":"additional","affiliation":[{"name":"Pneumonology, Otto von Guericke University Magdeburg Medical Faculty, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Lux","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Medical Informatics, Otto von Guericke University Magdeburg Medical Faculty, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Singla","sequence":"additional","affiliation":[{"name":"Pneumonology, Otto von Guericke University Magdeburg Medical Faculty, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Pneumonology, Otto von Guericke University Magdeburg Medical Faculty, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3233\/JND-221658","article-title":"Impact of Early Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis: A multicenter Randomized Controlled Trial","volume":"10","author":"M Sarasate","year":"2023","journal-title":"J Neuromuscul Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1111\/resp.13525","article-title":"NIV in amyotrophic lateral sclerosis: The \u2018when\u2019 and \u2018how\u2019 of the\n          matter","volume":"24","author":"C Morelot-Panzini","year":"2019","journal-title":"Respirology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000488667","article-title":"German National Guideline for Treating Chronic Respiratory Failure with Invasive and Non-Invasive Ventilation \u2013 Revised Edition 2017: 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Degener"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.4081\/monaldi.2012.146","article-title":"Pulmonary function in patients with amyotrophic lateral sclerosis at disease onset","volume":"77","author":"B Chandrasoma","year":"2012","journal-title":"Monaldi Arch Chest Dis"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1136\/thx.2006.072884","article-title":"The value of multiple tests of respiratory muscle strength","volume":"62","author":"J Steier","year":"2007","journal-title":"Thorax"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1136\/thx.38.8.616","article-title":"Respiratory muscle and pulmonary function in polymyositis and other proximal myopathies","volume":"38","author":"NM Braun","year":"1983","journal-title":"Thorax"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1164\/arrd.1978.117.3.437","article-title":"Respiratory muscle function in amyotrophic lateral sclerosis","volume":"117","author":"SM Kreitzer","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1183\/09031936.01.17201680","article-title":"In defence of the carbon monoxide transfer coefficient Kco (TL\/VA)","volume":"17","author":"JM Hughes","year":"2001","journal-title":"Eur Respir J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1183\/09031936.00037014","article-title":"Gas exchange and ventilation-perfusion relationships in the lung","volume":"44","author":"J Petersson","year":"2014","journal-title":"Eur Respir J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fneur.2019.00143","article-title":"Diaphragmatic Neurophysiology and Respiratory Markers in ALS","volume":"10","author":"M de Carvalho","year":"2019","journal-title":"Front Neurol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0002-9343(87)90897-7","article-title":"Flow-volume loop changes reflecting respiratory muscle weakness in chronic neuromuscular disorders","volume":"83","author":"WG Vincken","year":"1987","journal-title":"Am J Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1177\/0300060517728857","article-title":"Detection of early nocturnal hypoventilation in neuromuscular disorders","volume":"46","author":"F Trucco","year":"2018","journal-title":"J Int Med Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1136\/jnnp-2017-316515","article-title":"Prevalence of sleep apnoea and capnographic detection of nocturnal hypoventilation in amyotrophic lateral sclerosis","volume":"89","author":"M Boentert","year":"2018","journal-title":"J Neurol Neurosurg 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