{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T12:48:59Z","timestamp":1746794939396,"version":"3.37.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There has been an increase in the diagnosis of thyroid nodules in recent years.\n                    In addition to the well-known criteria, features that are likely to increase the\n                    risk of malignancy are in the research process. In this study, we aimed to\n                    evaluate the malignant potential of nodules that expand the thyroid capsule\n                    ultrasonographically. A total of 109 patients with thyroid capsule-expanding\n                    nodules and 288 patients with non-expanding nodules were included in the study.\n                    Demographical data, ultrasonography features, and cytology results were noted,\n                    and histopathological findings were determined in operated patients. While\n                    malignant cytology was detected in 5.5% of capsule-expanding nodules in FNAB\n                    results, this rate was 0.7% in the non-capsule expanding group (p&lt;0.001).\n                    According to the histopathological results, the incidence of malignancy was\n                    15.6% in the capsule-expanding nodule group, while it was 3.1% in the other\n                    group (p=0.001). As a result of logistic regression analysis, it was determined\n                    that the risk of malignancy increased by 4.44-fold (95% CI 1.4\u201313.8, p=0.01) in\n                    patients with capsule-expanding nodules. Other features that increased the risk\n                    of malignancy were hypoechogenicity, microcalcification, and irregular margin\n                    presence. In this study, we found that the risk of malignancy increased in\n                    nodules expanding the thyroid capsule. Based on the increasing study data on\n                    this subject, monitoring thyroid capsule expansion in nodules may take its place\n                    among the criteria for malignancy in future evaluations. <\/jats:p>","DOI":"10.1055\/a-2356-8223","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T22:49:57Z","timestamp":1719614997000},"page":"875-881","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Malignancy Risk in Nodules Expanding the Thyroid\n                    Gland Capsule"],"prefix":"10.1055","volume":"56","author":[{"given":"Ismail Emre","family":"Arslan","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Ministry of Health Ankara\n                    Etlik City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4957-9856","authenticated-orcid":false,"given":"Hayri","family":"Bostan","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Ministry of Health\n                    Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-7409","authenticated-orcid":false,"given":"Sema","family":"Hep\u015fen","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Ministry of Health Ankara\n                    Etlik City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Akhanli","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Erzurum B\u00f6lge E\u011fitim ve\n                    Ara\u015ft\u0131rma Hastanesi, Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Erkam","family":"Sencar","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Medicana International\n                    Ankara Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erman","family":"Cakal","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Ministry of Health Ankara\n                    Etlik City Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2362.2009.02162.x","article-title":"Very high prevalence of thyroid nodules detected by high frequency (13 MHz)\n                    ultrasound examination","volume":"39","author":"S Guth","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.mcna.2012.02.002","article-title":"Thyroid nodules","volume":"96","author":"G Popoveniuc","year":"2012","journal-title":"Med Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.2018.0898","article-title":"The diagnosis and management of thyroid nodules: a review","volume":"319","author":"C Durante","year":"2018","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.yasu.2006.06.003","article-title":"Current status of fine needle aspiration for thyroid nodules","volume":"40","author":"J B Ogilvie","year":"2006","journal-title":"Adv Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1470-2045(07)70034-7","article-title":"New therapeutic approaches for metastatic thyroid carcinoma","volume":"8","author":"E Baudin","year":"2007","journal-title":"Lancet Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1530\/JME-13-0160","article-title":"Different expression of TSH receptor and NIS genes in thyroid cancer: role of\n                    epigenetics","volume":"52","author":"M D'Agostino","year":"2014","journal-title":"J Mol Endocrinol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fendo.2015.00176","article-title":"Molecular targeted therapies of aggressive thyroid cancer","volume":"6","author":"S M Ferrari","year":"2015","journal-title":"Front Endocrinol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1634\/theoncologist.2014-0313","article-title":"Differentiated thyroid cancer: focus on emerging treatments for radioactive\n                    iodine-refractory patients","volume":"20","author":"J J Gruber","year":"2015","journal-title":"Oncologist"},{"key":"ref9","first-page":"293","article-title":"Management of nodular thyroid disease. 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