{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:05:19Z","timestamp":1785186319284,"version":"3.55.0"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa de Minas Gerais"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["444467\/2023-8"],"award-info":[{"award-number":["444467\/2023-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work investigated interactions ascribed to the administration of phytomedicines containing Valeriana officinalis and Piper methysticum with conventional drugs. The phytomedicines were characterized by HPLC and administered per os to male Wistar rats, either concomitantly or not with the CYP3A substrate midazolam. To distinguish between the presystemic or systemic effect, midazolam was given orally and intravenously. The effects on the P-gp substrate fexofenadine uptake by Caco-2 cells were examined. The valerenic acid content was 1.6\u2009\u00b1\u20090.1\u2009mg per tablet, whereas kavain was 13.7\u2009\u00b1\u20090.3\u2009mg\/capsule. Valerian and kava-kava extracts increased the maximum plasma concentration (Cmax) of midazolam 2- and 4-fold compared to the control, respectively. The area under the plasma concentrations versus time curve (AUC(0-\u221e)) was enhanced from 994.3\u2009\u00b1\u2009152.3\u2009ng.h\/mL (control) to 3041\u2009\u00b1\u2009398\u2009ng.h\/mL (valerian) and 4139\u2009\u00b1\u2009373\u2009ng.h\/mL (kava-kava). The\n          half-life of midazolam was not affected. These changes were attributed to the inhibition of midazolam metabolism by the enteric CYP3A since the i.\u200av. pharmacokinetic of midazolam remained unchanged. The kava-kava extract augmented the uptake of fexofenadine by 3.5-fold compared to the control. Although Valeriana increased the uptake of fexofenadine, it was not statistically significant to that of the control (12.5\u2009\u00b1\u20093.7\u2009ng\/mg protein vs. 5.4\u2009\u00b1\u20090.3\u2009ng\/mg protein, respectively). Therefore, phytomedicines containing V.\u00a0officinalis or P. methysticum inhibited the intestinal metabolism of midazolam in rats. Conversely, the P-gp-mediated transport of fexofenadine was preferably affected by kava-kava.<\/jats:p>","DOI":"10.1055\/a-2360-4808","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T23:06:22Z","timestamp":1721171182000},"page":"792-800","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Effects of Extracts Containing Valeriana officinalis and Piper methysticum on the Activities of Cytochrome P450 3A and P-Glycoprotein"],"prefix":"10.1055","volume":"90","author":[{"given":"Mariana de Lima","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, Campus Centro-Oeste Dona Lindu, Chanadour, Divin\u00f3polis-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Batista","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, Campus Centro-Oeste Dona Lindu, Chanadour, Divin\u00f3polis-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ednalva de Souza Pereira","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, Campus Centro-Oeste Dona Lindu, Chanadour, Divin\u00f3polis-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio Martins","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, Campus Centro-Oeste Dona Lindu, Chanadour, Divin\u00f3polis-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Rocha","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Campus Pampulha, Belo Horizonte-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-9413","authenticated-orcid":false,"given":"Isabela da Costa","family":"Cesar","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Campus Pampulha, Belo Horizonte-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8354-1843","authenticated-orcid":false,"given":"Whocely Victor","family":"de Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei, Campus Centro-Oeste Dona Lindu, Chanadour, Divin\u00f3polis-MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/jama.2023.26775","article-title":"Use of complementary health approaches overall and for pain management by US adults","volume":"331","author":"R L 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