{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:58:48Z","timestamp":1769043528097,"version":"3.49.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n               Objective\u2003Owing to the rarity of skull base chondrosarcomas (CS), much of its natural history and long-term impact on patient quality of life (QoL) are not well studied. This novel study demonstrates QoL among CS patients following radical treatment constituting surgery and postoperative radiotherapy over 2 decades.<\/jats:p><jats:p>\n               Study Design\u2003Retrospective review and prospective data collection to obtain patient demographic, tumor characteristics, clinical symptoms, and patient-reported QoL outcomes using the 36-Item Short Form Health Survey (SF-36).<\/jats:p><jats:p>\n               Setting\/Participants\u2003Patients diagnosed with CS who underwent radical intent surgical resection by the senior author and adjuvant early postoperative proton beam therapy.<\/jats:p><jats:p>\n               Results\u2003Twenty-eight skull base CS patients were identified, with 19 patients completing full treatment course. Mean long-term follow-up was 148.9 months. Diplopia symptom resolution was high. No significant deterioration in SF-36 Physical Health Component (PHC) and Mental Health Component (MHC) scores was observed at postoperative and long-term follow-up. General health was stable initially but deteriorated in long term (\u0394\u2009\u221218.88, minimal clinically important difference [MCID]: 9.86, p\u2009=\u20090.04). Compared with age-matched Canadian control patients, CS patients reported similar PHC scores at baseline and follow-up. CS patients reported lower MHC scores (45.8 vs. 50.9, p\u2009=\u20090.13) preoperatively, which persisted at follow-up decreasing by 1.9 (43.9 vs. 53.7, p\u2009=\u20090.03); this difference, however, did not reach MCID threshold of \u0394 5.9.<\/jats:p><jats:p>\n               Conclusion\u2003We present the longest follow-up data on CS demonstrating stable long-term QoL with aggressive surgery. Tumor control was high and preoperative tumor size did not affect long-term QoL. Preoperative QoL was lower among CS compared with Canadian normative data. Postoperatively, only the decline in physical functioning QoL scores exceeded MCID. At long-term follow-up, the decline in physical functioning, social functioning, and general health exceeded MCID. Overall, QoL among CS patients remained lower at long-term follow-up despite absence of tumor progression and resolution of symptoms.<\/jats:p>","DOI":"10.1055\/a-2360-9857","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T23:32:54Z","timestamp":1720222374000},"page":"429-437","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal Quality-of-Life Outcomes of Skull Base Chondrosarcoma Patients following Surgical Resection"],"prefix":"10.1055","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-912X","authenticated-orcid":false,"given":"Seika","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Kam","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada"},{"name":"Division of Neurosurgery, Department of Surgery, Vancouver General Hospital, Vancouver, BC, Canada"},{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Castle-Mendel","family":"Kirszbaum","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryojo","family":"Akagami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada"},{"name":"Division of Neurosurgery, Department of Surgery, Vancouver General Hospital, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"5960","DOI":"10.3390\/cancers13235960","article-title":"Primary skull base chondrosarcomas: a systematic review","volume":"13","author":"P Palmisciano","year":"2021","journal-title":"Cancers (Basel)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1159\/000509386","article-title":"Skull base chordomas and chondrosarcomas","volume":"110","author":"N Kremenevski","year":"2020","journal-title":"Neuroendocrinology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"106153","DOI":"10.1016\/j.clineuro.2020.106153","article-title":"Incidence and survival rates and trends of skull Base chondrosarcoma: a population-based study","volume":"198","author":"M Dibas","year":"2020","journal-title":"Clin Neurol Neurosurg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.wneu.2021.03.097","article-title":"Outcomes and patterns of care in adult skull base chondrosarcoma patients in the United States","volume":"150","author":"S Patel","year":"2021","journal-title":"World Neurosurg"},{"issue":"24","key":"ref5","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1097\/00007632-200012150-00008","article-title":"SF-36 health survey update","volume":"25","author":"J E Ware Jr","year":"2000","journal-title":"Spine"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/01.MLR.0000062554.74615.4C","article-title":"Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation","volume":"41","author":"G R Norman","year":"2003","journal-title":"Med Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"i43","DOI":"10.1093\/jrr\/rrt057","article-title":"Quality of life in patients with chordomas\/chondrosarcomas during treatment with proton beam therapy","volume":"54","author":"A Srivastava","year":"2013","journal-title":"J Radiat Res (Tokyo)"},{"issue":"13","key":"ref8","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.3390\/jcm11133733","article-title":"Quality of life after surgical treatment of brain tumors","volume":"11","author":"A Kr\u00f3likowska","year":"2022","journal-title":"J Clin Med"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1227\/00006123-199505000-00001","article-title":"Chordomas and chondrosarcomas of the cranial base: results and follow-up of 60 patients","volume":"36","author":"E Gay","year":"1995","journal-title":"Neurosurgery"}],"container-title":["Journal of Neurological Surgery Part B: Skull Base"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2360-9857.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T22:30:46Z","timestamp":1751668246000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2360-9857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":9,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,7,4]]},"published-print":{"date-parts":[[2025,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2360-9857","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6331","2193-634X"],"issn-type":[{"value":"2193-6331","type":"print"},{"value":"2193-634X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,7,5]]},"published":{"date-parts":[[2024,7,5]]}}}