{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:24:18Z","timestamp":1730870658095,"version":"3.28.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An experiment was conducted to evaluate the compatibility of menatetrenone with\n                    selected pharmaceutical excipients. Fourier Transform Infrared Spectroscopy\n                    (FTIR) was used to assess drug-excipient compatibility. The present research\n                    systematically investigates the FTIR spectrum of each chemical compound\n                    separately and their physical blends, analyzing for possible shifts, alterations\n                    or novel peak that may indicate chemical interactions. This study aims to\n                    utilize spectral data interpretation to detect potential compatibility problems\n                    that may occur while design and production of menatetrenone containing dosage\n                    forms ensuring their increased stability and effectiveness. The FTIR results\n                    demonstrated that all the pharmaceutical excipients were compatible with\n                    menatetrenone. In conclusion, the compatibility of pharmaceutical excipients\n                    with menatetrenone was successfully assessed using FTIR that will aid in future\n                    design of formulations containing menatetrenone as therapeutic moiety.<\/jats:p>","DOI":"10.1055\/a-2361-2895","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T23:08:48Z","timestamp":1722640128000},"page":"347-359","source":"Crossref","is-referenced-by-count":0,"title":["Assessing the Compatibility of Menatetrenone with Excipients: A\n                    Spectroscopic Approach and Implication in Drug Formulation\n                    Development"],"prefix":"10.1055","volume":"74","author":[{"given":"Widhilika","family":"Singh","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shom Prakash","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh,\n                    India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jpba.2013.06.016","article-title":"Drug\u2013excipient compatibility screening\u2014role of thermoanalytical and\n                    spectroscopic techniques","volume":"87","author":"R Chadha","year":"2014","journal-title":"Journal of pharmaceutical and biomedical analysis"},{"key":"ref2","first-page":"14","article-title":"Drug-Excipient compatibility studies: First step for dosage form\n                    development","volume":"4","author":"P Patel","year":"2015","journal-title":"The Pharma Innovation"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2302\/kjm.52.147]","article-title":"Treatment with vitamin D3 and\/or vitamin K2 for postmenopausal osteoporosis","volume":"52","author":"J Iwamoto","year":"2003","journal-title":"The Keio journal of medicine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11154-019-09517-9","article-title":"Endocrine roles of vitamin K-dependent-osteocalcin in the relation between bone\n                    metabolism and metabolic disorders","volume":"21","author":"E A Al-Suhaimi","year":"2020","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s007740050034","article-title":"Effects of menatetrenone on the bone and calcium metabolism in osteoporosis: a\n                    double-blind placebo-controlled study","volume":"16","author":"H Orimo","year":"1998","journal-title":"Journal of bone and mineral metabolism"},{"key":"ref6","first-page":"919","volume-title":"126 \u2013 Vitamin K. 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